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1.
Med Sante Trop ; 26(3): 312-317, 2016 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-27694090

RESUMO

INTRODUCTION: In Côte d'Ivoire, the prevalence of malnutrition among children younger than 5 years exceeded 5% in 2011 and was thus considered serious. This overall prevalence may nonetheless mask differences and specificities between regions and municipalities. This study sought to determine the prevalence and risk factors of malnutrition among children in this age group in a semi-urban area of Abidjan. METHODS: This exhaustive, descriptive, cross-sectional survey took place from May 6 to July 31, 2010. The children's nutritional status was determined according to the WHO criteria. Univariate and multivariate analysis of factors associated with malnutrition (social and demographic characteristics, immunization status, children's eating practices, and household characteristics) were studied. RESULTS: We visited 668 households and recruited 809 children. The prevalence of malnutrition was 22.5%. Multivariate analysis showed that the introduction of porridge after 6 months halved the risk of malnutrition. Risk tripled for children whose father's occupation did not guarantee a regular income. CONCLUSION: Among the factors highlighted by this study, dietary practices seem the most amenable to corrective action. For example, the adoption of outreach programs by the Maternal and Child Protection services could improve nutritional practices in households.


Assuntos
Desnutrição/epidemiologia , Pré-Escolar , Côte d'Ivoire/epidemiologia , Estudos Transversais , Pai , Feminino , Humanos , Renda , Lactente , Recém-Nascido , Masculino , Ocupações , Prevalência , Fatores de Risco , População Suburbana
3.
J Clin Pharm Ther ; 32(6): 579-84, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18021335

RESUMO

OBJECTIVE: To compare the pharmacokinetics and report on the clinical effects of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA), receiving long-term MTX or MTX plus chloroquine (CQ). METHODS: The pharmacokinetics of MTX, clinical characteristics (morning stiffness, joint tenderness and number of swollen joints) and biochemical markers (A-amyloid substance, C-reactive protein, erythrocyte sedimentation rate, fibrinogen and alpha-glycoprotein acid, alanine transaminase and aspartate transaminase) of the JIA patients were determined. Eight patients were treated with MTX (0.15 mg/kg) and another eight with MTX (0.15 mg/kg) plus CQ (4 mg/kg) for at least 6 months. RESULTS: All patients had polyarticular involvement and the clinical characteristics and biochemical markers were similar for the two groups. The pharmacokinetics of MTX were also similar with the Cmax and AUC values being 455.00 +/- 101.00 nm and 1469.92 +/- 299.77 nm/h for MTX group and 425.00 +/- 169.60 nm and 1560.73 +/- 615.49 nm/h for MTX plus CQ group, respectively. The respective creatinine clearance was 117.95 +/- 12.58 for MTX group and 99.17 +/- 22.65 mL/min for MTX plus CQ. CONCLUSION: The pharmacokinetics of MTX in JIA patients treated chronically with MTX are similar, with or without CQ co-treatment.


Assuntos
Antirreumáticos/farmacocinética , Cloroquina/administração & dosagem , Metotrexato/farmacocinética , Adolescente , Adulto , Área Sob a Curva , Artrite Juvenil , Criança , Quimioterapia Combinada , Feminino , Humanos , Masculino , Metotrexato/administração & dosagem
5.
Braz. j. med. biol. res ; 37(8): 1205-1213, Aug. 2004. tab, graf
Artigo em Inglês | LILACS | ID: lil-362555

RESUMO

We investigated the anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex (5.5 or 11 mg/kg) in male Wistar rats (180-300 g, N = 6) and compared it to free diclofenac (5 or 10 mg/kg) and to the combination of diclofenac (5 or 10 mg/kg) and zinc acetate (1.68 or 3.5 mg/kg). The carrageenin-induced paw edema and the cotton pellet-induced granulomatous tissue formation models were used to assess the anti-inflammatory activity, and the Hargreaves model of thermal hyperalgesia was used to assess the antinociceptive activity. To investigate the effect of orally or intraperitoneally (ip) administered drugs on cold-induced gastric lesions, single doses were administered before exposing the animals to a freezer (-18ºC) for 45 min in individual cages. We also evaluated the gastric lesions induced by multiple doses of the drugs. Diclofenac plus zinc complex had the same anti-inflammatory and antinociceptive effects as diclofenac alone. Gastric lesions induced by a single dose administered per os and ip were reduced in the group treated with zinc-diclofenac when compared to the groups treated with free diclofenac or diclofenac plus zinc acetate. In the multiple dose treatment, the complex induced a lower number of the most severe lesions when compared to free diclofenac and diclofenac plus zinc acetate. In conclusion, the present study demonstrates that the zinc-diclofenac complex may represent an important therapeutic alternative for the treatment of rheumatic and inflammatory conditions, as its use may be associated with a reduced incidence of gastric lesions.


Assuntos
Animais , Masculino , Ratos , Analgésicos , Anti-Inflamatórios , Diclofenaco , Úlcera Gástrica , Acetato de Zinco , Carragenina , Combinação de Medicamentos , Edema , Granuloma , Hiperalgesia , Ratos Wistar
6.
Braz J Med Biol Res ; 37(8): 1205-13, 2004 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15273822

RESUMO

We investigated the anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex (5.5 or 11 mg/kg) in male Wistar rats (180-300 g, N = 6) and compared it to free diclofenac (5 or 10 mg/kg) and to the combination of diclofenac (5 or 10 mg/kg) and zinc acetate (1.68 or 3.5 mg/kg). The carrageenin-induced paw edema and the cotton pellet-induced granulomatous tissue formation models were used to assess the anti-inflammatory activity, and the Hargreaves model of thermal hyperalgesia was used to assess the antinociceptive activity. To investigate the effect of orally or intraperitoneally (ip) administered drugs on cold-induced gastric lesions, single doses were administered before exposing the animals to a freezer (-18 degrees C) for 45 min in individual cages. We also evaluated the gastric lesions induced by multiple doses of the drugs. Diclofenac plus zinc complex had the same anti-inflammatory and antinociceptive effects as diclofenac alone. Gastric lesions induced by a single dose administered per os and ip were reduced in the group treated with zinc-diclofenac when compared to the groups treated with free diclofenac or diclofenac plus zinc acetate. In the multiple dose treatment, the complex induced a lower number of the most severe lesions when compared to free diclofenac and diclofenac plus zinc acetate. In conclusion, the present study demonstrates that the zinc-diclofenac complex may represent an important therapeutic alternative for the treatment of rheumatic and inflammatory conditions, as its use may be associated with a reduced incidence of gastric lesions.


Assuntos
Analgésicos/farmacologia , Anti-Inflamatórios/farmacologia , Diclofenaco/farmacologia , Úlcera Gástrica/tratamento farmacológico , Acetato de Zinco/farmacologia , Animais , Carragenina , Combinação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Edema/tratamento farmacológico , Granuloma/tratamento farmacológico , Hiperalgesia/tratamento farmacológico , Masculino , Ratos , Ratos Wistar , Úlcera Gástrica/induzido quimicamente
7.
Rev Saude Publica ; 34(4): 396-401, 2000 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10973160

RESUMO

OBJECTIVE: To determine the severity of dapsone (DDS) acute intoxication - an uncommon medical event - using clinical and laboratory parameters. METHODS: Two hundred and seventy four patients with acute DDS intoxication, aged 1 month to 50 years old, were studied and classified into four age groups. Clinical evaluation was assessed through a protocol and correlated with laboratory parameters. Spectrophotometric methods were used to analyze methemoglobinemia (MHbp) and dapsonemia (DDSp). RESULTS: The most prevalent clinical sign of intoxication was cyanosis, seen in 65.7% of the patients and in 100% of children less than 5 years of age. According to laboratory criteria, MHbp-related severe clinical intoxication was seen in 56.2% and DDSp-related occurred in 58% of the patients. Regarding DDSp, intoxication was considered severe when 20 tablets (100 mg each) were ingested, a median of 29 microg/ml. Regarding MHbp, intoxication was severe when 7.5 tablets were ingested, a median of 38% of the total Hb. The correlation between MHbp and DDSp was statistically significant (n=144, r=0.32, p<0.05). Negative correlation was observed between MHbp and the time elapsed since DDS intake (n=124, r=-0.34, p<0.001). There was also a negative correlation between DDSp and the time elapsed since DDS intake (n=63, r=-0.35, p<0.0001). CONCLUSIONS: Longitudinal analysis showed a significant association between methemoglobinemia and the time elapsed after the intake (t), according to the equation: Dapsonemia = 12.9256 - 0.0682t + 0.234 methemoglobinemia


Assuntos
Dapsona/intoxicação , Hansenostáticos/intoxicação , Metemoglobinemia/induzido quimicamente , Adolescente , Adulto , Criança , Pré-Escolar , Cianose/induzido quimicamente , Feminino , Humanos , Lactente , Estudos Longitudinais , Masculino , Metemoglobinemia/sangue , Pessoa de Meia-Idade , Estudos Retrospectivos , Índice de Gravidade de Doença , Estatísticas não Paramétricas
8.
Phytother Res ; 14(5): 359-61, 2000 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10925403

RESUMO

The toxicity of a hydroethanol extract of the subterranean part of Cochlospermum regium was evaluated in mice and rats. The extract had moderate acute toxicity when administered intraperitoneally and low toxicity upon oral administration. A subacute toxicity test revealed that the extract is well tolerated by these animals.


Assuntos
Malvaceae/toxicidade , Plantas Medicinais/química , Administração Oral , Animais , Feminino , Injeções Intraperitoneais , Rim/efeitos dos fármacos , Dose Letal Mediana , Fígado/efeitos dos fármacos , Masculino , Camundongos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/toxicidade , Raízes de Plantas , Ratos , Ratos Wistar , Baço/efeitos dos fármacos
9.
Phytomedicine ; 7(2): 117-21, 2000 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10839214

RESUMO

This study explored the interference by Maytenus aquifolium leaves hydroalcoholic (MALHE) extract, administered orally, on the pharmacokinetic and antiinflammatory activity of piroxicam in rats. The results showed no significant difference in piroxicam bioavailability with simultaneous application of MALHE. MALHE also had no effect on the inhibitory effect of piroxicam on inflammatory processes induced by carrageenan and complete Freund adjuvant.


Assuntos
Artrite Experimental/tratamento farmacológico , Piroxicam/farmacocinética , Piroxicam/uso terapêutico , Extratos Vegetais/farmacologia , Plantas Medicinais , Animais , Anti-Inflamatórios não Esteroides/farmacocinética , Anti-Inflamatórios não Esteroides/uso terapêutico , Brasil , Masculino , Medicina Tradicional , Mycobacterium tuberculosis , Folhas de Planta , Ratos , Ratos Sprague-Dawley , Ratos Wistar
10.
Am J Med Genet ; 87(3): 258-61, 1999 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-10564881

RESUMO

Börjeson-Forssman-Lehmann (BFL) syndrome is an X-linked recessive disorder characterized by minor facial anomalies, obesity, epilepsy, and severe mental retardation. The phenotype of male patients is usually severe, whereas that of carriers is less severe, suggesting X-linked incompletely recessive inheritance. A recent linkage study mapped the BFL syndrome gene to Xq26-q27. The etiology of the condition in female patients with full manifestations is not known, although nonrandom X-chromosome inactivation has been considered. We recently developed an assay for X-inactivation studies based on the methylation-specific polymerase chain reaction (PCR) technique. Using the methylation-specific PCR assay, a woman with typical findings of this syndrome was shown to have an extremely skewed X-inactivation pattern. This finding suggests that the full manifestations of the BFL syndrome in carriers may be caused by skewed X inactivation with a high proportion of cells in which the X chromosome with a normal gene be inactivated, leaving the X chromosome with a mutant gene active.


Assuntos
Mecanismo Genético de Compensação de Dose , Epilepsia/genética , Deficiência Intelectual/genética , Obesidade/genética , Cromossomo X/genética , Adulto , Face/anormalidades , Feminino , Humanos , Hipotonia Muscular/genética , Reação em Cadeia da Polimerase , Síndrome
11.
Diabetes Res Clin Pract ; 45(1): 25-30, 1999 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10499882

RESUMO

Although most of patients with non-insulin-dependent diabetes mellitus (NIDDM) have insulin resistance, it is unknown whether a molecule might interfere with insulin action. Membrane glycoprotein PC-1 (plasma cell antigen-1), which inhibits insulin receptor tyrosine kinase activity, was isolated from fibroblasts of NIDDM patients. Because PC-1 content in skeletal muscle and adipose tissue correlated with whole body insulin sensitivity, PC-1 might play a role in insulin resistance. In order to know whether PC-1 activity of fibroblasts is also elevated in Japanese NIDDM patients, and whether PC-1 activity correlates with the parameters of insulin resistance in vivo or not, we measured PC-1 activity of cultured fibroblasts from 17 patients with NIDDM and seven healthy controls. PC-1 activity of the NIDDM patients was 85.2 +/- 33.1 nmol/mg per min (mean +/- S.D.), and was higher than that of healthy controls (42.6 +/- 12.7 nmol/mg per min, P = 0.0002). Insulin sensitivity was measured in 11 of 17 NIDDM patients by the artificial pancreas. PC-1 activity of the patients with insulin resistance (glucose infusion rate < 3.0 mg/kg per min, n = 7) was elevated to 99.9 +/- 31.9 nmol/mg per min, while that of the other patients (n = 4) was 55.3 +/- 7.5 nmol/mg per min (P = 0.003). In conclusion, glycoprotein PC-1 activity of dermal fibroblasts is correlated with insulin resistance in patients with NIDDM.


Assuntos
Diabetes Mellitus Tipo 2/fisiopatologia , Fibroblastos/química , Resistência à Insulina/fisiologia , Glicoproteínas de Membrana/fisiologia , Diester Fosfórico Hidrolases , Pirofosfatases , Adulto , Idoso , Biópsia , Glicemia/análise , Células Cultivadas , Feminino , Técnica Clamp de Glucose , Hemoglobinas Glicadas/análise , Humanos , Masculino , Glicoproteínas de Membrana/análise , Pessoa de Meia-Idade , Contagem de Cintilação , Pele/patologia
12.
Gen Pharmacol ; 33(1): 67-71, 1999 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10428018

RESUMO

Complexation of piroxicam with zinc extends its absorption time in rats. The time of peak concentration value for complexed piroxicam was 5.27 hr compared to only 2.56 hr for the uncomplexed agent. Piroxicam and zinc-piroxicam show similar inhibitory effects on carrageenin-induced paw edema. Zinc-piroxicam is less irritating than piroxicam on the gastric mucosa.


Assuntos
Aminocaproatos , Anti-Inflamatórios não Esteroides/farmacocinética , Antiulcerosos/farmacocinética , Mucosa Gástrica/metabolismo , Piroxicam/farmacocinética , Ácido Aminocaproico/efeitos adversos , Ácido Aminocaproico/farmacocinética , Animais , Anti-Inflamatórios não Esteroides/efeitos adversos , Antiulcerosos/efeitos adversos , Carragenina/farmacologia , Quimioterapia Combinada , Edema/induzido quimicamente , Edema/prevenção & controle , Membro Posterior , Masculino , Piroxicam/efeitos adversos , Piroxicam/sangue , Ratos , Ratos Wistar , Estômago/efeitos dos fármacos , Estômago/patologia
13.
Gen Pharmacol ; 28(5): 695-8, 1997 May.
Artigo em Inglês | MEDLINE | ID: mdl-9184804

RESUMO

1. The absorption of piroxicam into the blood of rats is significantly slower after oral administration of piroxicam beta-cyclodextrin than of free piroxicam. 2. The pharmacokinetic profiles of piroxicam in rat lymph were very similar in both groups. 3. Bioavailability of piroxicam in plasma is higher after treatment with the inclusion product than with free piroxicam. On the other hand, bioavailability in lymph is higher when free piroxicam is administered.


Assuntos
Anti-Inflamatórios não Esteroides/sangue , Anti-Inflamatórios não Esteroides/farmacocinética , Ciclodextrinas/sangue , Ciclodextrinas/farmacocinética , Linfa/metabolismo , Piroxicam/sangue , Piroxicam/farmacocinética , beta-Ciclodextrinas , Animais , Disponibilidade Biológica , Combinação de Medicamentos , Hematócrito , Masculino , Ratos , Ratos Wistar
14.
Gen Pharmacol ; 26(4): 809-13, 1995 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-7635256

RESUMO

1. The effectiveness of the inclusion product of piroxicam with beta-cyclodextrin was compared to that of free piroxicam on inflammatory reactions by using three experimental inflammatory models in rats. 2. The inclusion compound showed anti-inflammatory effects similar to those of simple piroxicam on granuloma tissue formation and arthritis induced by complete Freund adjuvant. 3. In carrageenin-induced pleurisy, the piroxicam beta-cyclodextrin reduced leukocyte mobilization more intensely than non-complexed piroxicam. 4. These results suggest that beta-cyclodextrin is a useful tool for improving the efficacy of piroxicam.


Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Ciclodextrinas/farmacologia , Piroxicam/farmacologia , beta-Ciclodextrinas , Animais , Artrite Experimental/tratamento farmacológico , Carragenina , Adjuvante de Freund , Gossypium , Granuloma/induzido quimicamente , Granuloma/tratamento farmacológico , Masculino , Pleurisia/induzido quimicamente , Pleurisia/tratamento farmacológico , Ratos , Ratos Wistar
15.
Toxicon ; 32(4): 419-26, 1994 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8052996

RESUMO

In this study we investigated the ability of Bothrops jararaca venom (BjV) to induce hyperalgesia and the modulation of this effect by lipid mediators. It was found that intraplantar injection of BjV (1 to 25 micrograms) caused a dose and time-related hyperalgesia. The peak of the hyperalgesic response was 1 hr after injection of the venom and persisted for 24 hr with the higher dose. The BjV-induced hyperalgesia was markedly attenuated by dexamethasone. Dexamethasone blocks the generation of biologically active metabolites from arachidonic acid by inhibiting PLA2 activation. Inhibition of the cyclo-oxygenase pathway by indomethacin, or inhibition of lipoxygenases by NDGA both significantly inhibited BjV-induced hyperalgesia. Two antagonists of PAF, WEB2170 and BN52021, also significantly inhibited the initial phase of the hyperalgesia. These results suggest that hyperalgesia induced by BjV is, at least partially, mediated by lipid mediators such as prostaglandins, leukotrienes and PAF.


Assuntos
Bothrops , Venenos de Crotalídeos/toxicidade , Diterpenos , Eicosanoides/fisiologia , Hiperalgesia/induzido quimicamente , Fator de Ativação de Plaquetas/fisiologia , Animais , Azepinas/uso terapêutico , Venenos de Crotalídeos/antagonistas & inibidores , Dexametasona/uso terapêutico , Relação Dose-Resposta a Droga , Eicosanoides/biossíntese , Fibrinolíticos/uso terapêutico , Ginkgolídeos , Hiperalgesia/tratamento farmacológico , Indometacina/uso terapêutico , Lactonas/uso terapêutico , Masculino , Fator de Ativação de Plaquetas/antagonistas & inibidores , Ratos , Ratos Wistar , Triazóis/uso terapêutico
16.
J Inorg Biochem ; 41(1): 45-51, 1991 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-2019832

RESUMO

The flurbiprofen complex of copper(II) was prepared and characterized by IR, UV-VIS and EPR Spectroscopy, magnetic susceptibility, and thermogravimetric analysis. The compound was tested for in vivo anti-inflammatory and analgesic activities in rats. The inhibitory effect on carrageenin-induced paws inflammation and analgesic effect of copper flurbiprofen complex were similar to those of free flurbiprofen. However, the copper complex produced less gastric irritation than the parent drug.


Assuntos
Anti-Inflamatórios não Esteroides/síntese química , Edema/tratamento farmacológico , Flurbiprofeno/síntese química , Flurbiprofeno/farmacologia , Mucosa Gástrica/fisiologia , Mucosa Intestinal/fisiologia , Análise de Variância , Animais , Flurbiprofeno/química , Mucosa Gástrica/efeitos dos fármacos , Mucosa Intestinal/efeitos dos fármacos , Masculino , Estrutura Molecular , Ratos , Ratos Endogâmicos , Espectrofotometria Infravermelho
17.
Gen Pharmacol ; 22(3): 511-3, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1714412

RESUMO

1. Econazole released histamine from rat mast cells in vitro. This response was not affected by the addition of calcium or by prior treatment of mast cells with EDTA or cromoglycate. 2. Rat mast cells treated with econazole were stained by the vital dye trypan blue. 3. The intradermal injection of econazole increased vascular permeability. This response was antagonized by chlorpheniramine and cyproheptadine. 4. Our results demonstrate that econazole releases histamine by the "nonselective" mechanism. It is suggested that econazole inflammatory effects may be due to histamine release from mast cells.


Assuntos
Econazol/farmacologia , Liberação de Histamina/efeitos dos fármacos , Mastócitos/metabolismo , Animais , Cálcio/farmacologia , Bloqueadores dos Canais de Cálcio/farmacologia , Permeabilidade Capilar/efeitos dos fármacos , Clorfeniramina/farmacologia , Cromolina Sódica/farmacologia , Ciproeptadina/farmacologia , Ácido Edético/farmacologia , Feminino , Técnicas In Vitro , Mastócitos/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Azul Tripano
18.
Toxicology ; 61(3): 293-301, 1990 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-2109906

RESUMO

A single i.v. dose (0.1 mmol Be2+/kg) of beryllium chloride prolonged the duration of pentobarbital-induced sleep and zoxazolamine-induced paralysis, in rats. The effects are correlated with changes of the pharmacokinetic parameters and with the in vitro inhibition of both aliphatic and aromatic hydroxylation of pentobarbital and zoxazolamine. In vitro N-demethylation of meperidine and aminopyrine was partially inhibited while O-demethylation of quinidine was unaffected by liver microsomes of rats pretreated with beryllium salt. The findings give clues that beryllium chloride inhibits some forms of cytochrome P-450, especially those responsible for hydroxylation of substrates, like pentobarbital and zoxazolamine.


Assuntos
Berílio/farmacologia , Microssomos Hepáticos/enzimologia , Animais , Comportamento Animal/efeitos dos fármacos , Berílio/administração & dosagem , Citocromos b5/metabolismo , Depressão Química , Hidroxilação , Injeções Intravenosas , Masculino , NADPH-Ferri-Hemoproteína Redutase/metabolismo , Pentobarbital/sangue , Pentobarbital/farmacologia , Ratos , Ratos Endogâmicos , Reflexo/efeitos dos fármacos , Sono/efeitos dos fármacos , Zoxazolamina/sangue
19.
Gen Pharmacol ; 21(1): 131-4, 1990.
Artigo em Inglês | MEDLINE | ID: mdl-2298384

RESUMO

1. The interference of propylene glycol with anti-inflammatory effects of phenylbutazone was investigated. 2. Inhibitory effect of phenylbutazone on both carrageenin-induced edema and the cotton pellet granuloma was increased when propylene glycol was used as solvent. 3. Propylene glycol given alone inhibited carrageenin-induced edema and pleurisy, as well as granulomatous tissue formation. 4. Some pharmacokinetic parameters of phenylbutazone were also changed by propylene glycol administered simultaneously. 5. These results suggest that propylene glycol probably increases the anti-inflammatory effect of phenylbutazone by summation and by raising the plasma half-life and the distribution volume of phenylbutazone.


Assuntos
Anti-Inflamatórios não Esteroides , Fenilbutazona/farmacologia , Propilenoglicóis/farmacologia , Adrenalectomia , Animais , Permeabilidade Capilar/efeitos dos fármacos , Carragenina , Sinergismo Farmacológico , Edema/induzido quimicamente , Edema/tratamento farmacológico , Granuloma/induzido quimicamente , Granuloma/prevenção & controle , Injeções Intraperitoneais , Masculino , Fenilbutazona/administração & dosagem , Fenilbutazona/farmacocinética , Pleurisia/induzido quimicamente , Pleurisia/prevenção & controle , Propilenoglicóis/administração & dosagem , Ratos , Ratos Endogâmicos
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