RESUMO
This population-based cross-sectional study evaluates the clinical value of electroretinography and visual evoked potentials in childhood brain tumor survivors. A flash electroretinography and a checkerboard reversal pattern visual evoked potential (or alternatively a flash visual evoked potential) were done for 51 survivors (age 3.8-28.7 years) after a mean follow-up time of 7.6 (1.5-15.1) years. Abnormal electroretinography was obtained in 1 case, bilaterally delayed abnormal visual evoked potentials in 22/51 (43%) cases. Nine of 25 patients with infratentorial tumor location, and altogether 12 out of 31 (39%) patients who did not have tumors involving the visual pathways, had abnormal visual evoked potentials. Abnormal electroretinographies are rarely observed, but abnormal visual evoked potentials are common even without evident anatomic lesions in the visual pathway. Bilateral changes suggest a general and possibly multifactorial toxic/adverse effect on the visual pathway. Electroretinography and visual evoked potential may have clinical and scientific value while evaluating long-term effects of childhood brain tumors and tumor treatment.
Assuntos
Neoplasias Encefálicas/fisiopatologia , Encéfalo/fisiopatologia , Potenciais Evocados Visuais , Retina/fisiopatologia , Visão Ocular/fisiologia , Percepção Visual/fisiologia , Adolescente , Adulto , Neoplasias Encefálicas/complicações , Neoplasias Encefálicas/terapia , Sobreviventes de Câncer , Criança , Pré-Escolar , Estudos Transversais , Eletrorretinografia , Epilepsia/complicações , Epilepsia/fisiopatologia , Epilepsia/terapia , Seguimentos , Humanos , Hidrocefalia/complicações , Hidrocefalia/fisiopatologia , Hidrocefalia/terapia , Vias Visuais/fisiopatologia , Adulto JovemRESUMO
AIM: To compare the diagnostic accuracy of a computerized test, the CANTAB paired associate learning (PAL) to that of an established and validated noncomputerized test, the CERAD Wordlist Learning task in differentiating between normal aging, aMCI and AD in a cross-sectional design. METHODS: 58 participants were assessed (19 with mild probable AD, 17 aMCI, 22 healthy controls). RESULTS: The variables found to best discriminate between the three groups were the CANTAB PAL total errors adjusted (p < 0.0001, 81.0% of the cases correctly classified), and CERAD Wordlist Learning Delayed Recall (p < 0.0001, 77.6% of the cases correctly classified). Using both PAL total errors adjusted and Wordlist Learning Delayed Recall, 84.5% of the cases were correctly classified. DISCUSSION: The results suggest that the CANTAB could be used for screening of AD-typical memory impairment.