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European agriculture and rural development policies have promoted the diversity and genetic types of autochthonous breeds to increase sheep and goat biodiversity. Agri-environmental measures to support livestock farmers, have been the main tools used by these policies over the last twenty years. The COLAUTOC, "Collection of a seed bank for native sheep and goat breeds and strategies to increase their numbers", research project in Basilicata, Southern Italy, investigated sheep and goat farms with autochthonous breeds with results proving a reduction in the number of sheep and goat farms in general, particularly those with native breeds at risk of extinction, a clear indication of policy failure with a devastating loss of sheep and goat biodiversity. The COLAUTOC used a variety of methodological tools, including, desk analysis, focus groups, interviews, school workshops and a survey on sheep and goat meat consumption. The results indicated that a recovery in sheep and goat biodiversity could be achieved by supporting farm livestock strategies with a view to diversify production methods and activities, whilst, recognizing the value added to the territory, landscape, biodiversity and sustainability. The strategies identified by the COLAUTOC project require a local vision, using agri-environmental funds to invest in training on innovation for farms, provide tools to improve the quality of life in the rural areas, to increase communication channels to further knowledge and awareness of biodiversity. These strategies could contribute to meeting several 2030 Agenda goals.
RESUMO
BACKGROUND: The whole-body low-dose CT (WBLDCT) is the first-choice imaging technique in patients with suspected plasma cell disorder to assess the presence of osteolytic lesions. We investigated the performances of an optimized protocol, evaluating diagnostic accuracy and effective patient dose reduction using a latest generation scanner. METHODS AND MATERIALS: Retrospective study on 212 patients with plasma cell disorders performed on a 256-row CT scanner. First, WBLDCT examinations were performed using a reference protocol with acquisition parameters obtained from literature. A phantom study was performed for protocol optimization for subsequent exams to minimize dose while maintaining optimal diagnostic accuracy. Images were analyzed by three readers to evaluate image quality and to detect lesions. Effective doses (E) were evaluated for each patient considering the patient dimensions and the tube current modulation. RESULTS: A similar, very good image quality was observed for both protocols by all readers with a good agreement at repeated measures ANOVA test (p>0.05). An excellent inter-rater agreement for lesion detection was achieved obtaining high values of Fleiss' kappa for all the districts considered (p<0.001). The optimized protocol resulted in a 56% reduction of median DLP (151) mGycm, interquartile range (IQR) 128-188 mGycm vs. 345 mGycm, IQR 302-408 mGycm), of 60% of CTDIvol (2.2 mGy, IQR 1.9-2.7 mGy vs. 0.9 mGy, IQR 0.8-1.2 mGy). The median E value was about 2.6 mSv (IQR 1.7-3.5 mSv) for standard protocol and about 1.5 mSv (IQR 1.4-1.7 mSv) for the optimized one. Dose reduction was statistically significant with p<0.001. CONCLUSIONS: Protocol optimization makes ultra-low-dose WBLDCT feasible on latest generation CT scanners for patients with plasma cell disorders with effective doses inferior to conventional skeletal survey while maintaining excellent image quality and diagnostic accuracy. Dose reduction is crucial in such patients, as they are likely to undergo multiple whole-body CT scans during follow-up.