Novel MRI and histopathological findings in a young Bullmastiff cross dog with mitochondrial fission encephalopathy.

A 9-month-old male Bullmastiff cross dog was presented with a history of progressive proprioceptive ataxia and behavior changes. Neuroanatomical localization was multifocal with forebrain and vestibulo-cerebellum involvement. MRI identified moderate diffuse cerebral sulci widening, dilation of the ventricular system, and rounded, well-defined, bilaterally symmetrical T2W, FLAIR, and T2* hyperintense intra-axial lesions affecting the olivary nuclei. Histopathological examination was indicative of a primary mitochondrial disorder. This was confirmed following genetic analysis which identified mitochondrial fission encephalopathy with a homozygous frameshift variant in the MFF gene. This case report documents diagnostic imaging and histopathological findings not previously reported in dogs affected with mitochondrial fission encephalopathy, suggesting a different selective regional vulnerability of the neurons.

Computed tomography features and prevalence of focal diaphragmatic mineralization in 300 dogs.

A focal area of mineral attenuation is commonly observed in the diaphragmatic crura of canine patients undergoing a thoracic CT. There is no mention of this finding in either the human or veterinary medicine literature. This retrospective study evaluates 300 canine thoracic CT studies with the aim of describing the CT appearance of this finding and establishing a prevalence in a large cohort of dogs. The presence of the mineral focus and its CT characteristics, including length, attenuation, and appearance, were recorded and correlated with the patient's signalments and anamnesis. The focus was observed in 43 of 300 studies (14.3%). The most common appearance was a thin, millimetric, toothpick-like mineral attenuating structure in the confluence of the diaphragmatic crura, just ventral to the aorta. There was no association with adjacent potentially pathological changes. A significant correlation was found between the presence of the focus and the patient's body weight (P = .03), as well as with a brachycephalic conformation (P = .03). This focus of mineralization represents a relatively common incidental finding in the canine diaphragm and has no evident association with pathology.

Use of chin sling for conservative treatment of mandibular fracture in a guinea pig (Cavia porcellus).

OBJECTIVE: To describe a treatment for a mandibular fracture in a guinea pig (Cavia porcellus). ANIMAL: A 6-month-old sexually intact male guinea pig referred for a 24-hour history of hyporexia. CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES: Physical examination showed lateral displacement of the incisors and inflammation and crepitation during mandible lateralization. Imaging tests revealed a minimally displaced complete oblique fracture of the left mandible with fracture of the left mandibular first premolar tooth and incisor tooth. TREATMENT AND OUTCOME: Conservative treatment was established by placing a chin sling (CS) to immobilize the jaw and a nasogastric tube for nutritional support. Imaging tests repeated 3 weeks later showed initial callus formation, and the conservative treatment was discontinued. Follow-up examinations showed appetite and progressive weight gain. Five months later, the clinical crown of the left mandibular incisor was absent and a resorptive lesion on the left mandibular first premolar tooth was detected. Complete ossification of the fracture without premolar and moler teeth elongation was observed on control imaging tests. Ten months after initial examination, the patient was reportedly healthy with no signs of pain or dental disease. CLINICAL RELEVANCE: Jaw fracture treatments in guinea pigs are poorly described in the literature. Surgical treatment can be challenging in this species due to its skull and dental anatomy. Although CS was originally employed to increase the congruency of premolar and molar teeth after coronal reduction, this device yielded satisfactory results as a noninvasive, inexpensive treatment of a mandibular fracture in this guinea pig. Alopecia on the back of the head was the only undesired adverse effect associated with the CS.

Oesophageal pneumatosis: computed tomographic characteristics in three dogs (2018-2021).

BACKGROUND: Oesophageal pneumatosis (OP) is defined as the presence of gas within the oesophageal wall. The description of this condition in veterinary medicine is currently lacking. The pathogenesis of alimentary tract pneumatosis remains unclear. Current literature describes that access of gas into the oesophageal wall may occur by one or a combination of the following mechanisms: mucosal disruption, increased intra or extra-luminal pressure or dissection of gas from an extra-oesophageal source. OBJECTIVES: The aim of this multi-centric case series was to describe the computed tomography (CT) findings of OP in dogs. METHODS: Three adult dogs were included. One dog presented with gastrointestinal signs and general malaise while the other two presented with spontaneous facial and cervical subcutaneous emphysema. RESULTS: CT revealed different degrees of intramural gas along the oesophageal wall in all cases. The first dog was diagnosed with emphysematous gastritis based on the presence of gastric pneumatosis paired with compatible clinicopathological and endoscopic findings. This dog was successfully treated with antibiotics. The remaining two dogs were diagnosed with spontaneous pneumomediastinum and required no surgical or medical treatment. CONCLUSIONS: In all cases with OP, there was concurrent gastric pneumatosis. Gas extensively and circumferentially distributed with a banded shape along the oesophageal wall was present in patients with presumed mural gas dissection because of pneumomediastinum. Conversely, a focal and mild amount of mural gas with a tubular shape was identified in the distal segment of the oesophagus in the patient with emphysematous gastritis.

Diagnostic imaging and pathological findings of an abdominal mesenteric granular cell tumour in a dog.

A 12-year-old mixed-breed dog was presented for a follow-up examination after ablation of an auricular mast cell tumour. An abdominal ultrasound and computed tomography were performed and an irregular, ill-defined and partially mineralised lesion was observed around the caudal duodenal flexure without evidence of metastasis. The cytologic examination was highly suggestive of a granular cell tumour. Partial surgical ablation with histological and immunohistochemical examination of the lesion confirmed the diagnosis. According to our review of the literature, this is the first report documenting an abdominal granular cell tumour in a dog.