Subcutaneous Levetiracetam Administration in Latino Patients on Home Care.

Background: Levetiracetam has a favorable pharmacology profile to be used subcutaneously. However, its subcutaneous use is still considered off-label as this is beyond its license. The evidence base for its safety, tolerability, and efficacy is limited to observational studies. Objectives: To report the safety and efficacy of subcutaneous levetiracetam in Latino patients on home care. Design: Observational retrospective case series study. Subjects: Consecutive sample of Latino adults with life-limiting illnesses. Methods: A case series framework with 4 domains (selection, ascertainment, causality, and reporting) to ensure reporting quality was used. Additionally, 8 relevant outcomes established in a previous comprehensive review, were collected and reported. Adverse reactions were documented using the Common Terminology Criteria for Adverse Events. Results: Fifteen Latino patients with oncological and non-oncological diagnoses received subcutaneous levetiracetam for a mean of 21 days on home care. Levetiracetam was most frequently initiated subcutaneously due to loss of the oral route. The average dosage of subcutaneous levetiracetam was 1200 mg. Only 1 patient required a dose adjustment, and only 2 patients experienced a total of 5 seizures during the therapy trial. No adverse reactions were reported. Conclusions: Subcutaneous levetiracetam appears to be effective and safe. This case series of Latino patients in home care expands the evidence of its use in the home care setting. The preliminary data reported by now on multiple case series warrants robust trials.

Dataset of the livability performance of the city of Birmingham, UK, as measured by its citizen wellbeing, resource security, resource efficiency and carbon emissions.

This data article presents the UK City LIFE1 data set for the city of Birmingham, UK. UK City LIFE1 is a new, comprehensive and holistic method for measuring the livable sustainability performance of UK cities. The Birmingham data set comprises 346 indicators structured simultaneously (1) within a four-tier, outcome-based framework in order to aid in their interpretation (e.g., promote healthy living and healthy long lives, minimize energy use, uncouple economic vitality from CO2 emissions) and (2) thematically in order to complement government and disciplinary siloes (e.g., health, energy, economy, climate change). Birmingham data for the indicators are presented within an Excel spreadsheet with their type, units, geographic area, year, source, link to secondary data files, data collection method, data availability and any relevant calculations and notes. This paper provides a detailed description of UK city LIFE1 in order to enable comparable data sets to be produced for other UK cities. The Birmingham data set is made publically available at http://epapers.bham.ac.uk/3040/ to facilitate this and to enable further analyses. The UK City LIFE1 Birmingham data set has been used to understand what is known and what is not known about the livable sustainability performance of the city and to inform how Birmingham City Council can take action now to improve its understanding and its performance into the future (see "Improving city-scale measures of livable sustainability: A study of urban measurement and assessment through application to the city of Birmingham, UK" Leach et al. [2]).

Ansiedad, depreiión, afrontamiento y tca como predictores de cirugías plásticas cosétticas / Anxiey, depressiion, coping and eating disorders as cosmetic plastic surgery predictors

El presente estudio descriptivo correlacional tuvo como objetivo determinar si ansiedad, depresión, riesgo de trastorno de conducta alimentaria (TCA) y estilos de afrontamiento en interacción predicen la aceptación de cirugías estéticas cosméticas en una muestra conformada por 77 mujeres y hombres con edades comprendidas entre los 19 y 73 años de edad, residentes en la ciudad de Bogotá. Se empleó el Inventario de Ansiedad Estado/Rasgo, el apartado correspondiente a depresión de la versión española de la Entrevista Neuropsiquiátrica Internacional, el Inventario de Estilos de Afrontamiento y la Escala Abreviada y Modificada de Actitudes Alimentarias EAT-26-M. A través del análisis de ecuaciones estructurales con el programa estadístico AMOS se identificó el modelo predictivo conformado por variables como síntomas depresivos, riesgo de TCA, cantidad de hijos, estrato socioeconómico e historia familiar de cirugías predicen la aceptación de cirugías estéticas cosméticas en la población. Se discuten los hallazgos y las limitaciones, se sugieren futuras direcciones.

This correlational descriptive research aimed at assessing the predictive relation between psychological factors such as anxiety, depression, eating disorder (ED) risk and coping styles with cosmetic surgery acceptance. The sample included 77 women and men aged 19 to 73, living in Bogotá. The instruments used were State/Trait Anxiety Inventory (STAI), International Neuropsychiatric Interview (MINI) depression part, Coping Style Inventory -Abbreviated Scale and the Eating Attitudes property EAT-26-M. Were analyzed using Structural Equations with the Statistical program AMOS and concluded that the variables depressive symptoms, ED risk, number of children, socioeconomic condition and a family history of surgery predict acceptance of cosmetic plastic surgery in this sample. Findings and limitations are discussed and suggestions are provided for future research.