1.
Angew Chem Int Ed Engl
; 49(31): 5318-21, 2010 Jul 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20803702
2.
Org Lett
; 10(16): 3531-3, 2008 Aug 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18642828
RESUMO
A highly pure MUC1-derived glycopeptide dendrimer of 22 kDa was prepared by a sequential segment coupling, achieved by an N-alkylcysteine (NAC)-assisted thioesterification. The glycopeptide having C-terminal NAC was prepared by the Fmoc method and converted to the thioester by 3-mercaptopropionic acid treatment. The thioester was condensed with a lysine trimer carrying NAC to afford tetramer, which was then converted to the thioester. Two tetramers were condensed with ethylenediamine to give the octameric glycopeptide dendrimer.