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1.
Comb Chem High Throughput Screen ; 24(2): 286-293, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32729414

RESUMO

AIM AND OBJECTIVE: Sleep bruxism is a complicated disease, and its cause remains controversial. If the etiology of bruxism is resolved, the treatment can be adjusted to the prevailing aetiological factor. Thus, the aim of this study was to evaluate the oxidative stress level and serum prolidase activity in patients with sleep bruxism. MATERIALS AND METHODS: Seventy healthy subjects and 51 patients with sleep bruxism were included in this study, and blood samples from all patients were collected. Serum samples were analyzed for total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and prolidase activity. RESULTS: The prolidase, TOS, and OSI levels were significantly higher in patients with bruxism than in the healthy controls (p = 0.001, p = 0.001, p = 0.001, respectively). The TAS level was significantly lower in bruxism patients than in healthy controls (p = 0.003). CONCLUSION: The increased TOS, OSI, and prolidase levels and decreased TAS levels could be assumed to result in oxidative injury in patients with sleep bruxism. However, the study could not determine whether oxidative imbalance and increased serum prolidase levels could be a cause or a result of bruxism.


Assuntos
Dipeptidases/metabolismo , Bruxismo do Sono/metabolismo , Adulto , Dipeptidases/sangue , Feminino , Humanos , Masculino , Estresse Oxidativo , Bruxismo do Sono/sangue
2.
Odovtos (En línea) ; 22(1): 123-132, ene.-abr. 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1091512

RESUMO

ABSTRACT Objective: Bruxism is a jaw muscle activity disorder characterized by clenching or grinding of the teeth and can be seen in both children and adults. The purpose of this study is to evaluate the parental knowledge about bruxism in children. Methods: A cross-sectional study was conducted with 265 parents whose children were attended at University of Mersin pediatric dentistry and oral and maxillofacial surgery clinics. Children's ages varied from 6 months to 16 years old. A 20-questioned questionnaire was used to collect the data. IBM SPSS Statistics 22 for statistical analysis (SPSS IBM, Turkey) program was used for the analysis. Results: A total of 265 parents (159 were female and 106 were male) participated in the study. The majority of the parents were between the ages of 31-40 (60.8%). The rate of clenching and grinding of teeth during sleep (21.5%) was higher than the rate when they were awake (7.2%). The ratio of the parents seeking treatment for their children because of this harmful habit was very low (3.8%). The majortiy of parents (37.7%) reported that they seek help from dentists. The participants believed that bruxism was associated with dental problems (33.6%) and emotional factors (32.8%). A significant difference was found between the educational background of the parents and the ability to define bruxism. Conclusion: Parents had inadequate knowledge about bruxism in children and this was mostly related to the educational background of the parents.


RESUMEN Objetivo: El bruxismo es un trastorno de la actividad muscular de la mandíbula que se caracteriza por apretar o rechinar los dientes y se pueden ver tanto en niños como en adultos. El propósito de este estudio es evaluar el conocimiento de los padres sobre el bruxismo en sus niños. Métodos: se realizó un estudio transversal con 265 padres cuyos hijos fueron atendidos en las clínicas de Odontología Pediátrica y Cirugía Oral y Maxilofacial de la Universidad de Mersin. Las edades de los niños variaron de 6 meses a 16 años. Se utilizó un cuestionario de 20 preguntas para recopilar los datos. Para el análisis estadístico de los datos se utilizó el programa IBM SPSS Statistics 22 (SPSS IBM, Turquía). Resultados: Un total de 265 padres (159 mujeres y 106 hombres) participaron en el estudio. La mayoría de los padres tenían entre 31 y 40 años (60.8%). La tasa de niños que apretan y rechinan los dientes durante el sueño (21.5%) fue mayor que la tasa de los que lo hacen cuando están despiertos (7,2%). La proporción de padres que buscan tratamiento para sus hijos debido a este hábito dañino fue muy baja (3.8%). La mayoría de los padres (37.7%) informaron que buscan ayuda de los dentistas. Los participantes creían que el bruxismo estaba asociado con problemas dentales (33,6%) y factores emocionales (32,8%). Se encontró una diferencia significativa entre la formación académica de los padres y la capacidad de definir bruxismo. Conclusión: Los padres tenían un conocimiento inadecuado sobre el bruxismo en niños y esto estaba relacionado principalmente con la formación educativa de los padres.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Pais , Bruxismo , Criança , Conhecimento
3.
Int J Pediatr Otorhinolaryngol ; 125: 59-65, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31260809

RESUMO

OBJECTIVES: Among children with ß-thalassaemia, skeletal changes and abnormalities, such as decreased volume or obliteration of the sinus, result primarily from hypertrophy and expansion of the erythroid marrow due to ineffective erythropoiesis. This study evaluated the volumes and surface areas of the maxillary sinuses of children with ß-thalassaemia using cone beam computed tomography (CBCT), and compared these findings with corresponding measurements in age- and sex-matched control children. METHODS: CBCT images were retrospectively evaluated for 16 children with ß-thalassaemia, 19 children with a class I skeletal pattern (class I group), and 18 children with a class II skeletal pattern (class II group). After three-dimensional analyses and segmentation of each maxillary sinus, the volumes and surface areas were calculated. RESULTS: The volumes and surface areas of the right (p > 0.05 and p > 0.05) and left maxillary sinuses (p > 0.05 and p > 0.05) and SNA angles (p > 0.05) were not significantly different among the groups. The ANB (p < 0.05) and SNGoMe (p < 0.05) angles were significantly greater and the SNB (p < 0.05) angle was significantly smaller in the class II and thalassaemia groups than in the class I group. CONCLUSION: Children with thalassaemia tended to have lower maxillary sinus volumes and surface areas on both right and left sides, compared to those of children with class I and class II skeletal patterns; however, these differences were not statistically significant. In children with thalassaemia, a large intermaxillary discrepancy (ANB) indicated a tendency toward the class II skeletal pattern.


Assuntos
Seio Maxilar/diagnóstico por imagem , Talassemia beta/epidemiologia , Criança , Tomografia Computadorizada de Feixe Cônico , Feminino , Humanos , Imageamento Tridimensional , Masculino , Estudos Retrospectivos , Talassemia beta/complicações
4.
J Korean Assoc Oral Maxillofac Surg ; 44(5): 237-241, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30402416

RESUMO

OBJECTIVES: The aim of this study was to determine the rate of peer-reviewed publication of abstracts presented at the annual meetings of the Turkish Association of Oral and Maxillofacial Surgeons (TAOMS) and to identify the time to publication, subspecialty, and study design. MATERIALS AND METHODS: All abstracts accepted for presentation at a TAOMS meeting between 2007 and 2009 were identified from a book of abstracts and were searched for publication using PubMed and Google Scholar. The following variables were evaluated: publication rate, type of presentation (oral or poster), time to publication, subspecialty, study design, and name of the journal in which the article was published. RESULTS: A total of 478 abstracts were presented at the TAOMS meetings between 2007 and 2009. Of these, 140 abstracts (29.3%) were subsequently published in peer-reviewed journals, including 38.2% of oral presentations and 26.6% of poster presentations. The mean time from presentation to publication was 22 months. Regarding publication fields, research and emerging technologies presentations had the highest publication rate (100%). With regard to study type, animal study (70.0%) and basic research (55.0%) had the highest publication rates. CONCLUSION: Only 29.3% of abstracts presented at the TAOMS meeting were subsequently published as full-text articles. This rate was found to be similar to the previously reported publication rates in the field of oral and maxillofacial surgery.

5.
J Oral Maxillofac Surg ; 76(7): 1404-1413, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29605535

RESUMO

PURPOSE: The objective of this study was to investigate the effects of resveratrol on alveolar socket healing after tooth extraction in normal and cyclosporin A (CsA)-treated rats. MATERIALS AND METHODS: Seventy-two female Sprague-Dawley rats were separated into 4 groups of 18. Group 1 was injected with a placebo solution intraperitoneally. Group 2 was injected with resveratrol (10 µmol/kg) intraperitoneally. Groups 3 and 4 were injected with CsA (10 mg/kg) subcutaneously for 8 days once daily before tooth extraction. Next, the teeth were extracted and CsA injection continued until the animals were sacrificed. Eight days after commencing the CsA injections, group 4 was injected with resveratrol while continuing with CsA injections. Nine rats from each group were sacrificed on days 14 and 28, and sections were examined to assess the degree of inflammation, formation of connective tissue, and new bone formation. Immunohistochemical analysis was used to evaluate the alveolar socket healing process using osteocalcin and osteopontin markers. A P value less than .05 was considered significant. RESULTS: There was more new bone formation in group 2 than in the other 3 groups on day 14 after tooth extraction (P < .05), and there was more new bone formation in group 2 than in groups 3 and 4 on day 28 after extraction (P < .05). Based on the immunohistochemical assessment, the amount of osteocalcin and osteopontin labeling was greater in group 2 compared with the other 3 groups on day 14 (P < .05); however, on day 28 after extraction, it was greater in group 4 compared with group 3 (P < .05). CONCLUSIONS: Resveratrol improves alveolar socket healing in normal and CsA-treated rats. Resveratrol also increases levels of osteocalcin and osteopontin in normal and CsA-treated rats. These results suggest that this natural compound is useful for alveolar socket healing after tooth extraction.


Assuntos
Ciclosporina , Resveratrol , Alvéolo Dental , Cicatrização , Animais , Feminino , Ratos , Ciclosporina/farmacologia , Distribuição Aleatória , Ratos Sprague-Dawley , Resveratrol/farmacologia , Extração Dentária , Alvéolo Dental/efeitos dos fármacos , Cicatrização/efeitos dos fármacos
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