RESUMO
Metal Organic Frameworks (MOFs) offer unparalleled physical and sorption properties due to their chemical tunability and unmatched porosity. MOFs are consequently envisaged to play a key role in commercial gas storage and separation applications. However, it is essential to tackle their current market entry barriers, if mainstream adoption is to be realised. MOF Technologies is a pioneer in MOF commercialisation and has developed innovative solutions with unprecedented efficiency to bring these materials to market. A continuous, versatile and sustainable one-step production method of MOFs in shaped form is demonstrated for the first time. Its advantages for large-scale production and mass customisation are exemplified and validated with performance evaluation under realistic operating conditions.
Assuntos
Estruturas Metalorgânicas , PorosidadeRESUMO
Here it is shown that glycosaminoglycans (GAGs) with high molecular weight can be grafted via their reducing end on hyperbranched synthetic cores by oxime condensation without the need of any previous functionalisation of the polysaccharide. The versatility of this reaction is demonstrated by the use of hyaluronan, chondroitin sulfate and heparin with up to 60 sugar units. The isothermal calorimetry analysis demonstrated that the generated star-like glycopolymers have superior bioactivity. Moreover, when mixed with positively charged proteins (e.g., fibroblast growth factor-2, FGF-2) they form microfiber structures instead of the spherical nanocomplexes described for linear GAGs. The results suggest that the described star-like GAG are closer mimics of the proteoglycans at the structural and functional level and therefore have huge potential in the development of tissue engineering platforms and therapeutics by modulating the activity and presentation of various proteins such as growth factors.
Assuntos
Glicosaminoglicanos/química , Sulfatos de Condroitina/química , Fator 2 de Crescimento de Fibroblastos/química , Heparina/química , Ácido Hialurônico/química , Microtecnologia , Peso Molecular , Nanoestruturas/química , Oximas/química , Multimerização Proteica , Proteoglicanas/química , TermodinâmicaRESUMO
Con una encuesta a 50 cirujanos se valoró el conocimiento sobre responsabilidad médica con 10 problemas sobre el tema. Si bien en el 63% la respuesta fue correcta, este porcentaje no es real, pues hubo contestaciones muy dispares. Hay falta de información sobre responsabildiad profesional y ésta es posiblemente una de las causas de los frecuentes problemas entre cirujanos y pacientes