RESUMO
AIM: To analyze efficiency of ozone therapy, ultrasound and cryotherapy for infected and purulent wounds due to chronic venous insufficiency. MATERIAL AND METHODS: There were 127 patients with chronic venous insufficiency followed by chronic wounds. Efficacy of systemic and local ozone therapy was assessed. De Sole method was used to analyze chemiluminescent and spontaneous activity of neutrophils of peripheral blood. RESULTS: Advanced generation of active forms of oxygen was revealed in patients with chronic wounds and chronic venous insufficiency. Complex ozone therapy including intravenous administration of ozonized autologous blood, oxygen-ozone and ultrasonic exposure of the wound and cryogenic stimulation reduce painful period up to 3.1±0.6 days, accelerate epithelialization of the wound and normalize release of active forms of oxygen.
Assuntos
Neutrófilos/imunologia , Insuficiência Venosa/imunologia , Cicatrização/imunologia , Ferimentos e Lesões/imunologia , Ferimentos e Lesões/terapia , Doença Crônica , Crioterapia , Humanos , Medições Luminescentes , Oxidantes Fotoquímicos/uso terapêutico , Ozônio/uso terapêutico , Terapia por Ultrassom , Insuficiência Venosa/complicações , Insuficiência Venosa/fisiopatologia , Ferimentos e Lesões/etiologia , Ferimentos e Lesões/fisiopatologiaRESUMO
AIM: To develop predictive model for hepatic insufficiency in obstructive jaundice. MATERIAL AND METHODS: Obstructive jaundice was modeled by the author's method on 48 mini pigs, while morpho-functional features of erythrocytes were studied by using of INTEGRA Aura atomic force microscope (NT-MDT, Zelenograd, Russia). Histological specimens were stained with hematoxylin and eosin. Discriminant analysis was used to create predictive model for hepatic insufficiency. RESULTS: Mathematical model of hepatic insufficiency prediction has been developed. Sensitivity and specificity of this model were 94.1% and 74.2% respectively. Total percentage of correct predictions was 81.3%. CONCLUSION: Severe obstructive jaundice contributes erythrocyte's transformation from biconcave to dome-shaped followed by changes of its physical properties. Erythrocyte's volume and activity of cytolysis enzymes are the most informative to predict hepatic insufficiency. Our model allows us to diagnose this complication at early stages and to correct pre-, intra- and postoperative therapy.
Assuntos
Índices de Eritrócitos , Insuficiência Hepática , Complicações Intraoperatórias/prevenção & controle , Icterícia Obstrutiva , Testes de Função Hepática/métodos , Fígado/patologia , Complicações Pós-Operatórias/prevenção & controle , Animais , Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Insuficiência Hepática/sangue , Insuficiência Hepática/diagnóstico , Insuficiência Hepática/enzimologia , Insuficiência Hepática/etiologia , Complicações Intraoperatórias/etiologia , Icterícia Obstrutiva/complicações , Icterícia Obstrutiva/diagnóstico , Icterícia Obstrutiva/cirurgia , Microscopia de Força Atômica/métodos , Complicações Pós-Operatórias/etiologia , Valor Preditivo dos Testes , Prognóstico , Índice de Gravidade de Doença , Suínos , Porco MiniaturaRESUMO
The authors present the investigation of inpatient treatment of 137 patients with trophic ulcers of venous aethiology. All the patients were hospitalized in the "Road clinical hospital" on the Krasnoyarsk station. A comparative analysis of treatment results of the patients with trophic ulcers using different medical methods was made. The efficacy of combined use of low-frequency ultrasound and ozone therapy was proved.