1.
Bioorg Med Chem Lett
; 22(24): 7314-21, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23147076
RESUMO
SAR studies were performed on a series of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from a HTS hit both potency and selectivity could be improved. Modifications to the thiophene fusion and C-3 amides were studied. A representative compound 3t produced analgesia when dosed orally in inflammatory pain models of writhing and carrageenan-induced allodynia.