Factors related to drug consumption during pregnancy.

A survey on drug intake during pregnancy was carried out in a sample of 3268 women who delivered live-born infants in 11 hospitals located throughout Italy. A large questionnaire on drug use and other aspects of maternal life-style was administered within five days of delivery to 3112 women who consented to the interview. An overall mean consumption of 2.17 drugs per woman was reported. Apart from dietary supplements, the most used drugs were tocolytics, analgesics, and antibiotics. The proportion of women who did not use any drug was 17.3%. The role of some non-medical determinants of drug intake was evaluated as well. Geographic and socio-economic factors were seen to increase drug intake up to 44%, while the presence of anxiety provoked a 60% higher consumption of drugs other than dietary supplements. Other factors influencing drug use during pregnancy were rural vs. urban residence and smoking habits. The need for the recording of these socio-economic factors in surveys on drug use during pregnancy is emphasized.

[Effects of moderate maternal drinking on some neonatal parameters]. / Effetti di un moderato consumo di alcol in gravidanza su alcuni parametri neonatali.

A cross-sectional study was conducted on 2415 mother/newborn pairs, in order to evaluate the relationship between maternal alcohol consumption and birth weight. The results of this study are consistent with previous reports, that pointed out the casual relationship between maternal drinking during pregnancy, and reduction in birth weight. This reduction was evident only on the subset of smokers. A further stratification by the sex of newborn, showed a heavier effect on male newborns, who experienced a significant reduction of 6.2 grams in birth weight for each g of absolute alcohol consumed daily during pregnancy by mother. The findings of this study support the evidence of neonatal functional damages due to alcohol, even at very low doses. A strong increase of early jaundice were found among the outcome of exposed women (OD = 3.30; 95% CI 1.03-10.54).

[Bilateral kidney dysplasia with ascites in premature newborn infant]. / Displasia renale bilaterale con ascite in neonato prematuro.

The case refers to a premature newborn with anhydramnios and related foot malformations, renal dysplasia (Potter II-IV) and marked ascites. Hypoplasia of one umbilical cord artery was also found. Renal dysplasia according to Potter classification was difficult to be assessed being a borderline case between grade II and IV. The mother underwent methimazole and oestroprogestin treatment in the first period of pregnancy.

Antibody prevalence to torch agents in pregnant women and relative risk of congenital infections in Italy (Liguria).

A study on the prevalence of seropositivity to T.gondii, Rubella virus, Cytomegalovirus and Herpes simplex virus (type 1 and type 2) was carried out in pregnant women aged 15-45 years. An overall prevalence of 40.7% to T.gondii, of 90.1% to Rubella virus, of 80.8% to Cytomegalovirus, of 82.3% and of 69% to Herpes simplex virus, respectively type 1 and type 2 was found. Cytomegalovirus infection was prevalent in women from low socioeconomic background. Herpes simplex 1 infection was higher in women living in quarters of high density population, whereas antibody prevalence to Rubella virus was higher in women from high socioeconomic setting. The expected fetal risk for T.gondii, Rubella and Cytomegalovirus infections has been assessed on the basis of the yearly seroconversion rate for each pathogen in the study population and of the known transplacental transmission rates after primary and recurrent infection in pregnancy. Thus, the expected incidence of congenital T.gondii infection in this geographic area is 0.2-0.3%, of congenital Rubella infection of 0.02% and of congenital Cytomegalovirus infection of 0.3-1.15%.