Is Phosphorus the "Key" of cancer?

Bobko et al. reported a very interesting article concerning the impact of interstitial inorganic phosphate (Pi) on tumor progression. Previous studies have shown that blood levels of Pi might be related with either the presence or growth of cancer in the human body. Heroin-addicted persons have normal values of Pi, while the incidence of cancer in these individuals seems to be very low. The question rises: Is Pi the key of cancer? Further studies are definitely needed, focusing on the correlation between inorganic Pi and cancer.

What is the connection between serum phosphorus, cancer and heroin? A medical hypothesis based on observational studies.

Considering the results of a previous study in which 2321 regular heroin addicts who died without having stopped taking the drug since they had started - from various causes but none from cancer, may mean something. Our first thought was: Can't we hypothesize, reinforcing our previous view that heroin is a "barrier" against cancer and as the user gets in the methadone program he/she lacks the "barrier" and therefore is liable to develop cancer? We have already reported that the amount of blood phosphorus in heroin addicted is significantly lower than in healthy ones. Additionally we have introduced the potential clinical impact of serum phosphorus as a screening test for cancer. Phosphorus regulated by heroin might be the key for preventing the development of cancer in human organism, in terms of keeping the phosphorus in normal levels in the blood. Cases of cancer patients after methadone detox treatment are reported. In the present study, in 200 cancer patients who underwent radical radiotherapy (RT), the phosphorus level is generally returning to normal levels three months postirradiation. Phosphorus and cancer seem to be significantly associated, with heroin adapting phosphorus in normal values. The pharmaceutical companies should look deep inside the molecule of heroin, by means of an analogue with the potential impact against cancer but without the addictive effect to humans. It's obvious that further research is needed to obtain reliable statistical data.

"Hour-glass" shape of the uterus in the diagnosis and treatment of cervical pregnancy.

This study attempts to point out the importance of the anatomo-clinical finding of an "hour-glass" shape to the uterus in the diagnosis and treatment of cervical pregnancy. From 1973 to 2001, four cases of cervical pregnancy were treated in the 2nd Obstetrical and Gynecological Clinic of the Aristotelion University of Salonica. The incidence was 1:13,111 pregnancies (4 cervical in 52,446 pregnancies). Three of the patients underwent bilateral ligation of the anterior trunk of the internal iliac artery using absorbable ligatures. The fourth patient (a 42-year-old), elected to have a hysterectomy. All patients were well and discharged from hospital on the seventh postoperative day. Two of the three patients treated by ligation of the anterior trunk of the internal iliac arteries subsequently had normal pregnancies and deliveries. We lost contact with the third patient. The finding of an "hour-glass" uterine shape was very helpful in the diagnosis of cervical pregnancy. The Aristotelion University of Salonica has found that treatment by ligation of the anterior trunk of the internal iliac arteries is effective, causes no complications, never ends in hysterectomy, and maintains the normal menstrual cycles and reproductive ability of the woman.