The pharmacoepigenetic paradigm in cancer treatment.

Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role in the development and progression of cancer by significantly influencing gene activity and cellular function. This insight has led to the development of a novel class of therapeutic agents, known as epigenetic drugs. These drugs, including histone deacetylase inhibitors, histone acetyltransferase inhibitors, histone methyltransferase inhibitors, and DNA methyltransferase inhibitors, aim to modulate gene expression to curb cancer growth by uniquely altering the epigenetic landscape of cancer cells. Ongoing research and clinical trials are rigorously evaluating the efficacy of these drugs, particularly their ability to improve therapeutic outcomes when used in combination with other treatments. Such combination therapies may more effectively target cancer and potentially overcome the challenge of drug resistance, a significant hurdle in cancer therapy. Additionally, the importance of nutrition, inflammation control, and circadian rhythm regulation in modulating drug responses has been increasingly recognized, highlighting their role as critical modifiers of the epigenetic landscape and thereby influencing the effectiveness of pharmacological interventions and patient outcomes. Epigenetic drugs represent a paradigm shift in cancer treatment, offering targeted therapies that promise a more precise approach to treating a wide spectrum of tumors, potentially with fewer side effects compared to traditional chemotherapy. This progress marks a step towards more personalized and precise interventions, leveraging the unique epigenetic profiles of individual tumors to optimize treatment strategies.

Development and Characterization of a Hand Rub Gel Produced with Artisan Alcohol (Puntas), Silver Nanoparticles, and Saponins from Quinoa.

The emergence of the global pandemic (COVID-19) has directed global attention towards the importance of hygiene as the primary defense against various infections. In this sense, one of the frequent recommendations of the World Health Organization (WHO) is regular hand washing and the use of alcohol-based hand sanitizers. Ethanol is the most widely used alcohol due to its effectiveness in eliminating pathogens, ease of use, and widespread production. However, artisanal alcohol, generally used as a spirit drink, could be a viable alternative for developing sanitizing gels. In this study, the use of alcohol "Puntas", silver nanoparticles, and saponins from quinoa was evaluated to produce hand sanitizer gels. The rheological, physicochemical, and antimicrobial properties were evaluated. In the previous assays, the formulations were adjusted to be similar in visual viscosity to the control gel. A clear decrease in the apparent viscosity was observed with increasing shear rate, and an inversely proportional relationship was observed with the amount of ethyl alcohol used in the formulations. The flow behavior index (n) values reflected a pseudoplastic behavior. Oscillatory dynamic tests were performed to analyze the viscoelastic behavior of gels. A decrease in storage modulus (G') and an increase in loss modulus (G″) as a function of the angular velocity (ω) was observed. The evaluation of pH showed that the gels complied with the requirements to be in contact with the skin of the people, and the textural parameters showed that the control gel was the hardest. The use of artisan alcohol could be an excellent alternative to produce sanitizer gel and contribute to the requirements of the population.

CardiOmics signatures reveal therapeutically actionable targets and drugs for cardiovascular diseases.

Cardiovascular diseases are the leading cause of death worldwide, with heart failure being a complex condition that affects millions of individuals. Single-nucleus RNA sequencing has recently emerged as a powerful tool for unraveling the molecular mechanisms behind cardiovascular diseases. This cutting-edge technology enables the identification of molecular signatures, intracellular networks, and spatial relationships among cardiac cells, including cardiomyocytes, mast cells, lymphocytes, macrophages, lymphatic endothelial cells, endocardial cells, endothelial cells, epicardial cells, adipocytes, fibroblasts, neuronal cells, pericytes, and vascular smooth muscle cells. Despite these advancements, the discovery of essential therapeutic targets and drugs for precision cardiology remains a challenge. To bridge this gap, we conducted comprehensive in silico analyses of single-nucleus RNA sequencing data, functional enrichment, protein interactome network, and identification of the shortest pathways to physiological phenotypes. This integrated multi-omics analysis generated CardiOmics signatures, which allowed us to pinpoint three therapeutically actionable targets (ADRA1A1, PPARG, and ROCK2) and 15 effective drugs, including adrenergic receptor agonists, adrenergic receptor antagonists, norepinephrine precursors, PPAR receptor agonists, and Rho-associated kinase inhibitors, involved in late-stage cardiovascular disease clinical trials.

Publisher's Note: Realizing and Detecting a Topological Insulator in the AIII Symmetry Class [Phys. Rev. Lett. 119, 115301 (2017)].

This corrects the article DOI: 10.1103/PhysRevLett.119.115301.

Realizing and Detecting a Topological Insulator in the AIII Symmetry Class.

Topological insulators in the AIII (chiral unitary) symmetry class lack experimental realization. Moreover, fractionalization in one-dimensional topological insulators has not been yet directly observed. Our work might open possibilities for both challenges. We propose a one-dimensional model realizing the AIII symmetry class which can be realized in current experiments with ultracold atomic gases. We further report on a distinctive property of topological edge modes in the AIII class: in contrast to those in the well-studied BDI (chiral orthogonal) class, they have nonzero momentum. Exploiting this feature we propose a path for the detection of fractionalization. A fermion added to an AIII system splits into two halves localized at opposite momenta, which can be detected by imaging the momentum distribution.

Anomalous expansion of attractively interacting fermionic atoms in an optical lattice.

The interplay of thermodynamics and quantum correlations can give rise to counterintuitive phenomena in many-body systems. We report on an isentropic effect in a spin mixture of attractively interacting fermionic atoms in an optical lattice. As we adiabatically increase the attraction between the atoms, we observe that the gas expands instead of contracting. This unexpected behavior demonstrates the crucial role of the lattice potential in the thermodynamics of the fermionic Hubbard model.

Tonks-Girardeau gas of ultracold atoms in an optical lattice.

Strongly correlated quantum systems are among the most intriguing and fundamental systems in physics. One such example is the Tonks-Girardeau gas, proposed about 40 years ago, but until now lacking experimental realization; in such a gas, the repulsive interactions between bosonic particles confined to one dimension dominate the physics of the system. In order to minimize their mutual repulsion, the bosons are prevented from occupying the same position in space. This mimics the Pauli exclusion principle for fermions, causing the bosonic particles to exhibit fermionic properties. However, such bosons do not exhibit completely ideal fermionic (or bosonic) quantum behaviour; for example, this is reflected in their characteristic momentum distribution. Here we report the preparation of a Tonks-Girardeau gas of ultracold rubidium atoms held in a two-dimensional optical lattice formed by two orthogonal standing waves. The addition of a third, shallower lattice potential along the long axis of the quantum gases allows us to enter the Tonks-Girardeau regime by increasing the atoms' effective mass and thereby enhancing the role of interactions. We make a theoretical prediction of the momentum distribution based on an approach in which trapped bosons acquire fermionic properties, finding that it agrees closely with the measured distribution.

Mejora del estado nutricional de los ninos colombianos entre 1965 y 1989 / Improvement in the nutritional status of colombian children between 1965 and 1989

Se realizó un estudio con objeto de comparar las mediciones antropometricas obtenidas por el Ministerio de Salud Pública de Colombia en tres encuestas nutricionales (1965-66, 1977-80 y 1986-89) basadas en muestras nacionales comparables y representativas de la poblacion menor de 5 anos. Usando un mismo método de analisis, se establecio la tendencia de las tasas de prevalencia de la desnutricion general (bajo peso para la edad), cronica (baja talla para la edad) y aguda (bajo peso para la talla), asi como la de una serie de indicadores de desarrollo socioeconómico durante el período de 1965 a 1989. Los resultados revelan un descenso de las tasas de desnutricion general y cronica en ninos menores de 5 anos de casi 50. , y de la tasa de desnutricion aguda de 25,7. . Tambien muestran una marcada mejoria de numerosos indicadores de desarrollo, entre ellos el producto nacional bruto; la distribución del ingreso; el nivel de escolaridad y alfabetismo (sobre todo en mujeres); la integracion de la mujer a la fuerza laboral; las caracteristicas de las viviendas, la produccion de alimentos y la disponibilidad de calorias y proteinas per capita. Todo esto parece obedecer a un crecimiento económico sostenido y a políticas gubernamentales de fomento social, una mayor cobertura de la atención primaria de salud y programas nutricionales especificos. Se senalan algunos problemas nutricionales persistentes y posibles medidas para su solucion