An unusual cause of abdominal pain: Case report of a Superior Mesenteric Artery syndrome.

INTRODUCTION AND IMPORTANCE: Superior Mesenteric Artery (SMA) syndrome is an occlusive vascular disease, mainly caused by a severe weight loss that leads to a reduction of the fatty cushion around the SMA. Postprandial abdominal pain, early satiety, vomits, weight loss and malnutrition are the main symptoms of SMA syndrome. Therapy consists of nutritional support, while mini-invasive surgery is indicated when conservative measures are unsuccessful. CASE PRESENTATION: A 39-years old caucasian woman reported the following symptoms: epigastric pain irradiated up to the right hypochondrium, late post-prandial vomiting and severe weight loss. During previous hospitalizations a gastroscopy, a colonoscopy, and radiographic study of food transit were performed, these exams showed a slow gastric emptying. We performed an abdomen CT scan discovering SMA syndrome typical features. A duodenojejunostomy was performed in videolaparoscopy; the procedure was completed easily without complications. CLINICAL DISCUSSION: Debilitating conditions with severe weight loss or anatomic abnormalities are the main causes of SMA syndrome. Symptoms are usually unclear and non-specific. The commonest SMA syndrome features are highlighted with contrast CT. This syndrome is often misunderstood and not considered in differential diagnosis of abdominal pain, determining a delay in diagnosis and further weight loss. An early diagnosis is useful to choose the best treatment of the case. For severe cases, surgery represents the best treatment, especially duodenojejunostomy that is usually linked to rapid symptoms' resumptions without post-operative consequences. CONCLUSION: SMA syndrome should be included in differential diagnosis of abdominal pain. Severe cases can be treated with mini-invasive surgery.

Left-sided acute appendicitis in a patient with situs viscerum inversus totalis: A case report.

INTRODUCTION AND IMPORTANCE: Left-sided acute appendicitis (LSAA) is a very rare cause of acute abdomen, developing in association with two types of congenital anomalies like as situs viscerum inversus (SVI) and midgut malrotation (MM). Preoperative diagnosis of LSAA is a challenge because of its rarity and atypical presentation. Imaging may be helpful for determining the correct diagnosis. Surgery represents the standard treatment of LSAA. CASE PRESENTATION: A 67-year-old Caucasian male with presented to the Emergency Department with a two-day history of left lower quadrant (LLQ) abdominal pain, nausea, vomiting, diarrhea and fever. Physical examination revealed LLQ abdominal rebound tenderness with guarding. Laboratory tests reported high levels of C-reactive protein and neutrophilic leukocytosis. Abdominal contrast-enhanced computed tomography showed a LSAA with intraluminal appendicoliths, fat infiltration and pericecal fluid collection in a patient with SVI. The patient underwent laparoscopic appendectomy: a gangrenous and perforated appendicitis was sectioned and removed with drainage of pericecal abscess. The postoperative course of the patient was uneventful. CLINICAL DISCUSSION: LSAA is characterized by anatomical variation of appendix and atypical presentation. Preoperative clinical diagnosis of LSAA is very difficult and imaging may be helpful for determining the correct diagnosis, as well as confirming SVIT or MM. Laparoscopic appendectomy represents the correct treatment of LSAA. CONCLUSION: LSAA is a rare surgical emergency that should be considered in the differential diagnosis of patients with LLQ abdominal pain. Preoperative diagnosis of LSAA needs a high index of suspicion and is facilitated by imaging. Surgery represents the appropriate treatment of LSAA.

Post-transplant colitis after kidney transplantation: clinical, endoscopic and histological features.

Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for the increased risk of gastrointestinal complications in kidney transplant recipients. Differentiating the various forms of post-transplant colitis is challenging, since most have similar clinical and histological features. This study evaluated the incidence of post-transplant gastrointestinal complications during screening colonoscopy. Kidney transplant recipients undergoing a colonoscopy for any reasons in the period 2014-2018 were included. Among the 134 patients completing the colonoscopy, 74 patients (56%) had an abnormal finding: an adenoma was found in 25 patients (18.6%), while 19 patients (14.1%) had colitis. Mycophenolic acid/related colitis was the most common colitis (6%), while 7 patients (5.2%) developed a de novo inflammatory bowel disease. Patients with post-transplant colitis were younger and with shorter time from transplant compared to patients without colitis. In conclusions, immunosuppression may predispose kidney transplant recipients to an increased risk of post-transplant colitis. Diagnostic colonoscopy should be encouraged in all transplant patients with refractory diarrhea and gastrointestinal symptoms to allow a prompt diagnosis and a timely treatment, finally improving the quality of life and long-term outcomes of affected patients.

Kidney Transplantation From Donors with Hepatitis B.

The growing demand for organ donors to supply the increasing number of patients on kidney waiting lists has led most transplant centers to develop protocols that allow safe use of organs from donors with special clinical situations previously regarded as contraindications. Deceased donors with previous hepatitis B may be a safe resource to increase the donor pool even if there is still controversy among transplantation centers regarding the use of hepatitis B surface antigen-positive donors for renal transplantation. However, when allocated to serology-matched recipients, kidney transplantation from donors with hepatitis B may result in excellent short-term outcome. Many concerns may arise in the long-term outcome, and studies must address the evaluation of the progression of liver disease and the rate of reactivation of liver disease in the recipients. Accurate selection and matching of both donor and recipient and correct post-transplant management are needed to achieve satisfactory long-term outcomes.