Acute treatment of intracranial hemorrhage complicated by hemophilia a and emicizumab therapy.

Among patients with hemophilia A with or without FVIII inhibitors, emicizumab prophylaxis has demonstrated significantly reduced bleeding events. However, emicizumab interferes with clotting-based assays used for monitoring FVIII activity, resulting in falsely elevated FVIII activity. This lack of accurate monitoring can complicate the dosing of intravenous therapeutic FVIII clotting factor concentrates in the treatment of critical bleeding events. This case report aims to inform providers who frequently treat hemophilia-associated hemorrhages about emicizumab's effect on clotting-based assays essential for monitoring factor replacement.

When fatigue promotes striving: confirmation that success importance moderates resource depletion influence on effort-related cardiovascular response.

Undergraduate volunteers performed an easy (fatigue low) or difficult (fatigue high) counting task and then were presented a difficult scanning task with instructions that the task was or was not diagnostic of an important ability (low versus high ego-involvement, respectively). As expected, systolic blood pressure responses in the second work period were positively proportional to fatigue where ego-involvement (and, thus, success importance) was high, but not where ego-involvement (and, thus, importance) was low. The pressure findings provide fresh support for the suggestion of a recent fatigue analysis that importance should moderate fatigue influence on effort-related CV responses to a performance challenge so long as fatigued performers view success as possible, conceptually replicating and extending effects from a previous fatigue experiment.