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INTRODUCTION: Non-ketotic hyperglycaemic hemichorea-hemiballismus (NHHH) is often secondary to middle-aged and elderly diabetic people with poor-controlled diabetes; Fahr's disease (FD) is another rare neurological disorder characterized by abnormal calcified deposits in the brain that control movement. We described a rare case of NHHH combined with a heterozygous mutation (SLC20A2) resulting in one family with FD. CASE PRESENTATION: The patient has a 30-day history of involuntary choreic movements of the left limbs and left face. In addition, he had a bit of speech slurred and walked unsteadily. He was diagnosed with type 2 diabetes mellitus two months ago. Over the past two months, he had noticed that urination, appetite, and water volume increased obviously and weight loss drastically. Other problems such as dizziness, headache, difficulty swallowing, nausea, and vomiting did not occur. T1- weighted MRI indicts characteristic contralateral basal ganglia hyper-intensity. During hospitalization, he was injected insulin and oral haloperidol. And the clinical symptoms improved, but parkinsonism symptoms emerge soon after discharge. The parkinsonism symptoms were gradually improved after adjusting medications. Combined with the subsequent genetic test results, we attribute it to NHHH with FD. CONCLUSION: It is relatively rare that NHHH or FD is both presents. We should use antipsychotics with caution in these patients to avoid parkinsonism symptoms.
RESUMO
To study the distribution of phenol compounds in a retired refinery site, 21 soil sampling sites and 8 shallow groundwater wells were investigated. The results showed, shallow unconfined groundwater of the site was in a serious pollution situation and the phenols concentration was much higher than quality standard for ground water. Confined water sample was slightly contaminated by phenols and the total quality was good. Approximately half of the area was heavily polluted by phenol compounds. According to the retired refinery layout, the phenols pollution distribution in shallow groundwater and soil exhibited the regional similarity. The highly contaminated area was production workshop, oil tank and plant storage. Horizontal diffusion of pollutants was not serious. Vertical diffusion of pollutants was different, and a site with pollutant diffusion was deeper than ten meters. The 2-chlorophenol, 2-nitrophenol, 2,4-xylenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol, 2,4-dinitrophenol and 2-methyl-4,6-dinitrophenol in typical soils were analyzed by GC/MS. It showed that concentrations of seven phenol compounds were 0.01-232.96 mg x kg(-1), and the concentrations of 2,4-dinitrophenol and 2-methyl-4,6-dinitrophenol were high.