1.
J Org Chem
; 89(7): 5153-5158, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38485493
RESUMO
We have disclosed a novel metal-free tandem cyclization reaction for the synthesis of 3-methyleneisoindolin-1-ones starting from ester-functionalized aziridines. This strategy can be effectively promoted by DBU and carboxylic acids. Mechanistically, it involves sequential ring opening of aziridines with carboxylic acids, lactamization, and elimination of carboxylic acids.