RESUMO
The aim of this paper is to establish the haematological and organic changes in halothane-sensitive and halothane-resistant pigs in the course of experimental anisakiasis. Experiments were carried out on two groups of pigs (3 animals each). The pigs from the first group were given fifty A. simplex B larvae, the pigs from the second one received ten larvae and then again fifteen larvae each after the 5th and 6th days. The number of leucocytes, neutrophils, lymphocytes, monocytes and eosinophils was greater--different in both series, but similar in halothane (stress)-resistance and -sensitive pigs. In the case of sensitive pigs much greater reactive changes were found in the stomach submucosa than in that of resistant pigs. In this group of pigs nematode larvae have also been traced in the submucosa of the same organ.
Assuntos
Anisaquíase/patologia , Estômago/patologia , Animais , Anisaquíase/sangue , Feminino , Contagem de Leucócitos , Masculino , SuínosRESUMO
In halothane-susceptible (Hal+) and halothane-resistant (Hal-) Belgian Landrace pigs, the influence of immobilization stress on cytotoxic activity of natural killer (NK) cells was evaluated. Four hour immobilization causes biphasic changes in cytotoxicity, i.e. an initial increase followed by a subsequent depression. In both groups of pigs stress-induced suppression of NK cell activity lasted for several days in the post stress period. Throughout the experiment, i.e. before, during and after stress, the level of cytotoxicity was higher in Hal+ than in Hal- pigs.
Assuntos
Citotoxicidade Imunológica , Halotano/administração & dosagem , Imobilização/fisiologia , Células Matadoras Naturais/imunologia , Estresse Fisiológico/imunologia , Animais , Resistência a Medicamentos , Feminino , Masculino , SuínosRESUMO
The level of blood immune complexes was determined in 100 healthy women with a normal course of pregnancy. The results of our studies indicate that using the test of EA rosette forming inhibition it is possible to detect circulating immune complexes in pregnant women. We have not demonstrated a quantitative interdependence of immune complexes level upon a number of past pregnancies.
Assuntos
Complexo Antígeno-Anticorpo , Gravidez , Feminino , Humanos , Formação de RosetaAssuntos
Complexo Antígeno-Anticorpo/análise , Neoplasias Encefálicas/imunologia , Neoplasias Hipofisárias/imunologia , Adenoma/imunologia , Adolescente , Adulto , Idoso , Astrocitoma/imunologia , Neoplasias Encefálicas/secundário , Neoplasias Cerebelares/imunologia , Craniofaringioma/imunologia , Feminino , Glioblastoma/imunologia , Hemangiossarcoma/imunologia , Humanos , Masculino , Neoplasias Meníngeas/imunologia , Meningioma/imunologia , Pessoa de Meia-Idade , Neurilemoma/imunologiaRESUMO
Sera from 51 melanoma patients and from 55 healthy donors were examined for the presence of immune complexes (ICs) by the EA-rosette forming cell inhibition assay. Using a cut-off point of 5% rosette inhibition, ICs were found in 144 out of 213 sera from patients with melanoma (67.6%) and in 11 out of 55 control subjects (20%, p less than 0.001). The percentage of positive results was significantly lower in patients with no evidence of disease (60%) than in patients with clinical symptoms of their tumor (localized disease -- 80%, p less than 0.02, metastatic disease -- 78%, p less than 0.05). The mean inhibitory rate in patients with metastatic disease (21%) was higher than in patients with localized tumor (15.1%, the difference not significant) and than in patients with no evidence of disease (10%, p less than 0.01). The high levels of ICs or a tendency for their increasing in most cases accompanied the dissemination of the neoplasm. The stabilization of ICs on the low levels was found to be a prognostically favorable sign.