Green nanotechnology in phytosynthesis and its efficiency in inhibiting bacterial biofilm formation: implications for medicine.

Nanotechnology is used in several biomedical applications, including antimicrobial and antibiofilm applications using nanomaterials. Bacterial biofilm varies according to the strain; the matrix is very strong and resistant. In this sense, phytosynthesis is an important method for combating bacterial biofilms through the use of metallic nanoparticles (silver, gold, or copper) with increased marketing and technical-scientific potential. In this review, we seek to gather the leading publications on the use of phytosynthesized metallic nanoparticles against bacterial biofilms. Furthermore, this study aims to understand the main characteristics and parameters of these nanomaterials, their antibiofilm efficiency, and the presence or absence of cytotoxicity in these developed technologies.

Environmental Implications Associated with the Development of Nanotechnology: From Synthesis to Disposal.

Nanotechnology remains under continuous development. The unique, fascinating, and tunable properties of nanomaterials make them interesting for diverse applications in different fields such as medicine, agriculture, and remediation. However, knowledge about the risks associated with nanomaterials is still poorly known and presents variable results. Furthermore, the interaction of nanomaterials with biological systems and the environment still needs to be clarified. Moreover, some issues such as toxicity, bioaccumulation, and physicochemical transformations are found to be dependent on several factors such as size, capping agent, and shape, making the comparisons even more complex. This review presents a comprehensive discussion about the consequences of the use and development of nanomaterials regarding their potential risks to the environment as well as human and animal health. For this purpose, we reviewed the entire production chain from manufacturing, product development, applications, and even product disposal to raise the important implications at each stage. In addition, we present the recent developments in terms of risk management and the recycling of nanomaterials. Furthermore, the advances and limitations in the legislation and characterization of nanomaterials are also discussed.

Graphene Oxide (GO) Materials-Applications and Toxicity on Living Organisms and Environment.

Graphene-based materials have attracted much attention due to their fascinating properties such as hydrophilicity, high dispersion in aqueous media, robust size, high biocompatibility, and surface functionalization ability due to the presence of functional groups and interactions with biomolecules such as proteins and nucleic acid. Modified methods were developed for safe, direct, inexpensive, and eco-friendly synthesis. However, toxicity to the environment and animal health has been reported, raising concerns about their utilization. This review focuses primarily on the synthesis methods of graphene-based materials already developed and the unique properties that make them so interesting for different applications. Different applications are presented and discussed with particular emphasis on biological fields. Furthermore, antimicrobial potential and the factors that affect this activity are reviewed. Finally, questions related to toxicity to the environment and living organisms are revised by highlighting factors that may interfere with it.