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1.
Epidemiol Infect ; 145(15): 3219-3225, 2017 11.
Artigo em Inglês | MEDLINE | ID: mdl-28903791

RESUMO

An outbreak of mumps within a student population in Scotland was investigated to assess the effect of previous vaccination on infection and clinical presentation, and any genotypic variation. Of the 341 cases, 79% were aged 18-24. Vaccination status was available for 278 cases of whom 84% had received at least one dose of mumps containing vaccine and 62% had received two. The complication rate was 5·3% (mainly orchitis), and 1·2% were admitted to hospital. Genetic sequencing of mumps virus isolated from cases across Scotland classified 97% of the samples as genotype G. Two distinct clusters of genotype G were identified, one circulating before the outbreak and the other thereafter, suggesting the virus that caused this outbreak was genetically different from the previously circulating virus. Whilst the poor vaccine effectiveness we found may be due to waning immunity over time, a contributing factor may be that the current mumps vaccine is less effective against some genotypes. Although the general benefits of the measles-mumps-rubella (MMR) vaccine should continue to be promoted, there may be value in reassessing the UK vaccination schedule and the current mumps component of the MMR vaccine.


Assuntos
Surtos de Doenças/estatística & dados numéricos , Vacina contra Caxumba/uso terapêutico , Vírus da Caxumba/genética , Caxumba/epidemiologia , Estudantes/estatística & dados numéricos , Adolescente , Surtos de Doenças/prevenção & controle , Feminino , Variação Genética/genética , Humanos , Masculino , Caxumba/imunologia , Caxumba/prevenção & controle , Caxumba/virologia , Vacina contra Caxumba/imunologia , Vírus da Caxumba/imunologia , Reação em Cadeia da Polimerase em Tempo Real , Escócia/epidemiologia , Adulto Jovem
2.
Br J Cancer ; 114(5): 582-9, 2016 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-26931370

RESUMO

BACKGROUND: To document the effect of bivalent HPV immunisation on cervical cytology as a screening test and assess the implications of any change, using a retrospective analysis of routinely collected data from the Scottish Cervical Screening Programme (SCSP). METHODS: Data were extracted from the Scottish Cervical Call Recall System (SCCRS), the Scottish Population Register and the Scottish Index of Multiple Deprivation. A total of 95 876 cytology records with 2226 linked histology records from women born between 1 January 1988 and 30 September 1993 were assessed. Women born in or after 1990 were eligible for the national catch-up programme of HPV immunisation. The performance of cervical cytology as a screening test was evaluated using the key performance indicators used routinely in the English and Scottish Cervical Screening Programmes (NHSCSP and SCSP), and related to vaccination status. RESULTS: Significant reductions in positive predictive value (16%) and abnormal predictive value (63%) for CIN2+ and the mean colposcopy score (18%) were observed. A significant increase (38%) in the number of women who had to be referred to colposcopy to detect one case of CIN2+ was shown. The negative predictive value of negative- or low-grade cytology for CIN2+ increased significantly (12%). Sensitivity and specificity, as used by the UK cervical screening programmes, were maintained. CONCLUSIONS: The lower incidence of disease in vaccinated women alters the key performance indicators of cervical cytology used to monitor the quality of the screening programme. These findings have implications for screening, colposcopy referral criteria, colposcopy practice and histology reporting.


Assuntos
Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/uso terapêutico , Lesões Intraepiteliais Escamosas Cervicais/patologia , Displasia do Colo do Útero/patologia , Neoplasias do Colo do Útero/patologia , Estudos de Coortes , Colposcopia , Citodiagnóstico , Detecção Precoce de Câncer , Feminino , Humanos , Teste de Papanicolaou , Valor Preditivo dos Testes , Estudos Retrospectivos , Escócia , Sensibilidade e Especificidade , Lesões Intraepiteliais Escamosas Cervicais/diagnóstico , Lesões Intraepiteliais Escamosas Cervicais/prevenção & controle , Reino Unido , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/prevenção & controle , Esfregaço Vaginal , Adulto Jovem , Displasia do Colo do Útero/diagnóstico , Displasia do Colo do Útero/prevenção & controle
3.
Intern Med J ; 46(4): 452-7, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26765074

RESUMO

BACKGROUND: Human papillomavirus (HPV) vaccines are currently utilised globally in national immunisation programmes. While evidence from clinical trials and epidemiological studies suggest that the HPV vaccines are both effective and safe, concerns about the safety of the vaccine and scientifically unproven associations with severe adverse events following immunisation have led to dramatic decreases in vaccine uptake in Japan and acceptance issues in other countries. AIM: In Scotland, we utilised hospital admissions data to assess the impact of the HPV immunisation programme on the incidence of 60 diagnoses between 2004 and 2014 in both girls and boys; with boys acting as a comparator group. METHODS: Tabular and graphical outputs of the number of admissions, the incidence and the incidence ratio of 59 diagnoses were created to assess trends before and after the introduction of the HPV vaccine. Data linkage was utilised to investigate further the increase in Bell palsy diagnoses. RESULTS: Fifty-four diagnoses showed no change in incidence following the introduction of the national immunisation programme, and while small increases in incidence were observed for Bell palsy, coeliac disease, ovarian dysfunction, juvenile onset of type 1 diabetes, demyelinating disease and juvenile rheumatoid arthritis, none was statistically significant. CONCLUSIONS: Consistent with previous evidence, we present disaggregate data that reiterate the safety of both HPV vaccines.


Assuntos
Sistemas de Notificação de Reações Adversas a Medicamentos/tendências , Programas de Imunização/tendências , Vacinas contra Papillomavirus/efeitos adversos , Admissão do Paciente/tendências , Adolescente , Anemia Hemolítica/induzido quimicamente , Anemia Hemolítica/epidemiologia , Criança , Feminino , Humanos , Programas de Imunização/métodos , Masculino , Escócia/epidemiologia , Trombocitopenia/induzido quimicamente , Trombocitopenia/epidemiologia
4.
Br J Cancer ; 114(5): 576-81, 2016 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-26794278

RESUMO

BACKGROUND: To measure the uptake of first invitation to cervical screening by vaccine status in a population-based cohort offered HPV immunisation in a national catch-up campaign. METHODS: A retrospective observational study of routinely collected data from the Scottish Cervical Screening Programme. Data were extracted and linked from the Scottish Cervical Call Recall System, the Scottish Population Register and the Scottish Index of Multiple Deprivation. Records from 201 023 women born between 1 January 1988 and 30 September 1993 were assessed. Women born in or after 1990 were eligible for the national catch-up programme of HPV immunisation. Attendance for screening was within 12 months of the first invitation at age 20 years. RESULTS: There was a significant decline in overall attendance from the 1988 cohort to the 1993 cohort with the adjusted attendance ratio of the 1988 cohort being 1.49 times (95% CI 1.46-1.52) that of the 1993 cohort. Immunisation compensated for this decrease in uptake with unvaccinated individuals having a reduced ratio of attendance compared with those fully vaccinated (RR=0.65, 95% CI 0.64-0.65). Not taking up the opportunity for HPV immunisation was associated with an attendance for screening below the trend line for all women before the availability of HPV immunisation. CONCLUSIONS: HPV immunisation is not associated with the reduced attendance for screening that had been feared. Immunised women in the catch-up cohorts appear to be more motivated to attend than unimmunised women, but this may be a result of a greater awareness of health issues. These results, while reassuring, may not be reproduced in routinely immunised women. Continued monitoring of attendance for the first smear and subsequent routine smears is needed.


Assuntos
Detecção Precoce de Câncer/estatística & dados numéricos , Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/uso terapêutico , Neoplasias do Colo do Útero/prevenção & controle , Estudos de Casos e Controles , Feminino , Humanos , Estudos Retrospectivos , Escócia , Neoplasias do Colo do Útero/diagnóstico , Adulto Jovem
5.
J Med Microbiol ; 65(2): 142-146, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26704297

RESUMO

The reported incidence of Legionnaires' disease caused by Legionella longbeachae has increased since 2008 in Scotland. While microbiological and epidemiological studies have identified exposure to growing media as a risk factor for infection, little is known about the differences regarding disease risk factors, clinical features and outcomes of infection with L. longbeachae when compared with L. pneumophila. A nested case-case study was performed comparing 12 L. longbeachae cases with 25 confirmed L. pneumophila cases. Fewer L. longbeachae infected patients reported being smokers [27% (95% CI 2-52%) vs. 68% (95% CI 50-86%), P = 0.034] but more L. longbeachae patients experienced breathlessness [67% (95% CI 40-94%) vs. 28% (95% CI 10-46%), P = 0.036]. Significantly more L. longbeachae-infected patients received treatment in intensive care [50% (95% CI 22-78%) vs. 12% (95% CI 0-25%), P = 0.036]. However, the differences in diagnostic methods between the two groups may have led to only the most severe cases of L. longbeachae being captured by the surveillance system. No differences were observed in any of the other pre-hospital symptoms assessed. Our results highlight the similarity of Legionnaires' disease caused by L. pneumophila and L. longbeachae, and reinforce the importance of diagnostic tools other than the urinary antigen assays for the detection of non-L. pneumophila species. Unfortunately, cases of community-acquired pneumonia caused by Legionella species will continue to be underdiagnosed unless routine testing criteria changes.


Assuntos
Legionella longbeachae/fisiologia , Legionella pneumophila/fisiologia , Doença dos Legionários/microbiologia , Idoso , Antibacterianos/administração & dosagem , Feminino , Humanos , Legionella longbeachae/efeitos dos fármacos , Legionella longbeachae/isolamento & purificação , Legionella pneumophila/efeitos dos fármacos , Legionella pneumophila/isolamento & purificação , Doença dos Legionários/diagnóstico , Doença dos Legionários/tratamento farmacológico , Doença dos Legionários/epidemiologia , Masculino , Pessoa de Meia-Idade , Saúde Pública , Escócia/epidemiologia
6.
Br J Cancer ; 111(9): 1824-30, 2014 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-25180766

RESUMO

BACKGROUND: In Scotland, a national HPV immunisation programme began in 2008 for 12- to 13-year olds, with a catch-up campaign from 2008 to 2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established. METHODS: We analysed colposcopy data from a cohort of women born between 1988 and 1992 who entered the Scottish Cervical Screening Programme (SCSP) and were aged 20-21 in 2008-2012. RESULTS: By linking datasets from the SCSP and colposcopy services, we observed a significant reduction in diagnoses of cervical intraepithelial neoplasia 1 (CIN 1; RR 0.71, 95% CI 0.58 to 0.87; P=0.0008), CIN 2 (RR 0.5, 95% CI 0.4 to 0.63; P<0.0001) and CIN 3 (RR 0.45, 95% CI 0.35 to 0.58; P<0.0001) for women who received three doses of vaccine compared with unvaccinated women. CONCLUSIONS: To our knowledge, this is one of the first studies to show a reduction of low- and high-grade CIN associated with high uptake of the HPV bivalent vaccine at the population level. These data are very encouraging for countries that have achieved high HPV vaccine uptake.


Assuntos
Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/uso terapêutico , Displasia do Colo do Útero/prevenção & controle , Neoplasias do Colo do Útero/prevenção & controle , Adulto , Estudos de Coortes , Colposcopia , Feminino , Seguimentos , Humanos , Programas de Rastreamento , Programas Nacionais de Saúde , Gradação de Tumores , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/epidemiologia , Infecções por Papillomavirus/patologia , Infecções por Papillomavirus/virologia , Prevalência , Prognóstico , Escócia/epidemiologia , Displasia do Colo do Útero/epidemiologia , Displasia do Colo do Útero/patologia , Displasia do Colo do Útero/virologia , Neoplasias do Colo do Útero/epidemiologia , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/virologia , Vacinação , Potência de Vacina , Esfregaço Vaginal , Adulto Jovem
7.
Br J Cancer ; 110(11): 2804-11, 2014 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-24736582

RESUMO

BACKGROUND: In 2008, a national human papillomavirus (HPV) immunisation programme began in Scotland for 12-13 year old females with a three-year catch-up campaign for those under the age of 18. Since 2008, three-dose uptake of bivalent vaccine in the routine cohort aged 12-13 has exceeded 90% annually, while in the catch-up cohort overall uptake is 66%. METHODS: To monitor the impact of HPV immunisation, a programme of national surveillance was established (pre and post introduction) which included yearly sampling and HPV genotyping of women attending for cervical screening at age 20. By linking individual vaccination, screening and HPV testing records, we aim to determine the impact of the immunisation programme on circulating type-specific HPV infection particularly for four outcomes: (i) the vaccine types HPV 16 or 18 (ii) types considered to be associated with cross-protection: HPV 31, 33 or 45; (iii) all other high-risk types and (iv) any HPV. RESULTS: From a total of 4679 samples tested, we demonstrate that three doses (n=1100) of bivalent vaccine are associated with a significant reduction in prevalence of HPV 16 and 18 from 29.8% (95% confidence interval 28.3, 31.3%) to 13.6% (95% confidence interval 11.7, 15.8%). The data also suggest cross-protection against HPV 31, 33 and 45. HPV 51 and 56 emerged as the most prevalent (10.5% and 9.6%, respectively) non-vaccine high-risk types in those vaccinated, but at lower rates than HPV 16 (25.9%) in those unvaccinated. CONCLUSIONS: This data demonstrate the positive impact of bivalent vaccination on the prevalence of HPV 16, 18, 31, 33 and 45 in the target population and is encouraging for countries which have achieved high-vaccine uptake.


Assuntos
Papillomavirus Humano 16/imunologia , Papillomavirus Humano 18/imunologia , Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/administração & dosagem , Neoplasias do Colo do Útero/prevenção & controle , Vacinação , Estudos Transversais , Relação Dose-Resposta Imunológica , Feminino , Genótipo , Papillomavirus Humano 16/genética , Papillomavirus Humano 18/genética , Humanos , Infecções por Papillomavirus/epidemiologia , Prevalência , Sensibilidade e Especificidade , Neoplasias do Colo do Útero/epidemiologia , Neoplasias do Colo do Útero/virologia , Potência de Vacina , Adulto Jovem
9.
Epidemiol Infect ; 142(8): 1636-9, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24125434

RESUMO

Giardiasis, caused by the intestinal protozoan parasite Giardia intestinalis (synonyms: G. lamblia, G. duodenalis), is one of the most frequent parasites to infect the Scottish population. Transmission of the infective cysts in faecal matter is commonly via food and/or water. Giardia is subdivided into assemblages, where clinical and epidemiological differences have been described between assemblages A and B. This snapshot descriptive epidemiological study examines 30 positive cases of Giardia of which 72% (n = 21) were shown to be assemblage A, 14% (n = 4) assemblage B and 10% (n = 3) mixed assemblages (A and B). There was a 2:3 female:male ratio of affected individuals with foreign travel recorded in 22 of these cases. The commonest symptom was diarrhoea which was reported in 80% of cases followed by tiredness. Five cases required hospitalization emphasizing the importance of gaining a greater understanding of how Giardia assemblages influence clinical outcomes to assist in formulating guidelines to manage potential Giardia outbreaks.


Assuntos
Técnicas de Genotipagem , Giardia/classificação , Giardia/genética , Giardíase/epidemiologia , Giardíase/parasitologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Análise por Conglomerados , Diarreia/epidemiologia , Diarreia/parasitologia , Diarreia/patologia , Estudos Epidemiológicos , Feminino , Genótipo , Giardia/isolamento & purificação , Giardíase/patologia , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Epidemiologia Molecular , Fatores de Risco , Escócia/epidemiologia , Distribuição por Sexo , Viagem , Adulto Jovem
10.
Epidemiol Infect ; 142(1): 56-62, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23591075

RESUMO

Previous evidence has suggested an association between cryptosporidiosis and consumption of unfiltered drinking water from Loch Katrine in Scotland. Before September 2007, the water was only micro-strained and chlorinated; however, since that time, coagulation and rapid gravity filtration have been installed. In order to determine risk factors associated with cryptosporidiosis, including drinking water, we analysed data on microbiologically confirmed cases of cryptosporidiosis from 2004 to 2010. We identified an association between the incidence of cryptosporidiosis and unfiltered Loch Katrine drinking water supplied to the home (odds ratio 1.86, 95% confidence interval 1.11-3.11, P = 0.019). However, while filtration appears to be associated with initially reduced rates of cryptosporidiosis, evidence suggests it may paradoxically make those consumers more susceptible to other transmission routes in the long-term. These findings support implementation of similar treatment for other unfiltered drinking-water supplies, as a means of reducing cryptosporidiosis associated with drinking water.


Assuntos
Criptosporidiose/epidemiologia , Água Potável/parasitologia , Filtração/métodos , Purificação da Água/métodos , Abastecimento de Água/normas , Análise de Variância , Criptosporidiose/prevenção & controle , Humanos , Incidência , Modelos Logísticos , Fatores de Risco , Escócia/epidemiologia
11.
Zoonoses Public Health ; 57(7-8): 493-8, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19912614

RESUMO

Outbreaks of Q fever are rare in the UK. In 2006, the largest outbreak of Q fever in Scotland occurred at a co-located slaughterhouse and cutting plant with 110 cases. Preliminary investigations pointed to the sheep lairage being the potential source of exposure to the infective agent. A retrospective cohort study was carried out among workers along with environmental sampling to guide public health interventions. A total of 179 individuals were interviewed of whom 66 (37%) were migrant workers. Seventy-five (41.9%) were serologically confirmed cases. Passing through a walkway situated next to the sheep lairage, a nearby stores area, and being male were independently associated with being serologically positive for Q fever. The large proportion of migrant workers infected presented a significant logistical problem during outbreak investigation and follow up. The topic of vaccination against Q fever for slaughterhouse workers is contentious out with Australasia, but this outbreak highlights important occupational health issues.


Assuntos
Matadouros , Coxiella burnetii/isolamento & purificação , Surtos de Doenças , Doenças Profissionais/epidemiologia , Febre Q/epidemiologia , Migrantes , Adulto , Animais , Anticorpos Antibacterianos/sangue , Estudos de Coortes , Coxiella burnetii/imunologia , Coleta de Dados , Feminino , Humanos , Incidência , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Febre Q/diagnóstico , Febre Q/parasitologia , Febre Q/transmissão , Estudos Retrospectivos , Fatores de Risco , População Rural , Escócia/epidemiologia , Estudos Soroepidemiológicos , Ovinos , Adulto Jovem
12.
Zoonoses Public Health ; 57(7-8): 487-92, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19638164

RESUMO

The spatial and temporal epidemiology of human cryptosporidiosis was described by analysing sporadic cases reported in Scotland from 2005 to 2007. Measures of livestock density and human population density were explored as indicators of the geographical variation in prevalence. Cryptosporidium parvum was more common in areas with lower human population densities, with a higher ratio of the number of farms to human inhabitants and with a higher ratio of the number of private water supplies to human inhabitants. Cryptosporidium parvum caused disease in humans in rural areas and in areas with high ruminant livestock density, whereas Cryptosporidium hominis was more common in the more densely human populated areas of Scotland. The association of private water supplies and increased Cryptosporidium reports merits further public health efforts.


Assuntos
Criptosporidiose/epidemiologia , Cryptosporidium/isolamento & purificação , Surtos de Doenças/estatística & dados numéricos , Abastecimento de Água , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criação de Animais Domésticos , Animais , Criança , Pré-Escolar , Criptosporidiose/parasitologia , Cryptosporidium/classificação , Feminino , Humanos , Incidência , Lactente , Recém-Nascido , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Vigilância da População , Saúde Pública , População Rural , Escócia/epidemiologia , Estações do Ano , População Urbana , Adulto Jovem
13.
Epidemiol Infect ; 137(12): 1713-20, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19534843

RESUMO

On 24 August 2008, an outbreak alert regarding cases of acute gastroenteritis in Podgorica triggered investigations to guide control measures. From 23 August to 7 September, 1699 cases were reported in Podgorica (population 136 000) and we estimated the total size of the outbreak to be 10 000-15 000 corresponding to an attack rate of approximately 10%. We conducted an age- and neighbourhood-matched case-control study, microbiologically analysed faecal and municipal water samples and assessed the water distribution system. All cases (83/83) and 90% (80/90) [corrected] of controls drank unboiled chlorinated municipal water [matched odds ratio (mOR) 11.2, 95% confidence interval (CI), 1.6-infinity]. Consumption of bottled water was inversely associated with illness (mOR 0.3, 95% CI 0.1-0.8). Analyses of faecal samples identified six norovirus genotypes (21/38 samples) and occasionally other viruses. Multiple defects in the water distribution system were noted. These results suggest that the outbreak was caused by faecally contaminated municipal water. It is unusual to have such a large outbreak in a European city especially when the municipal water supply is chlorinated. Therefore, it is important to establish effective multiple-barrier water-treatment systems whenever possible, but even with an established chlorinated supply, sustained vigilance is central to public health.


Assuntos
Infecções por Caliciviridae/epidemiologia , Surtos de Doenças/estatística & dados numéricos , Gastroenterite/epidemiologia , Gastroenterite/virologia , Microbiologia da Água , Abastecimento de Água , Adolescente , Adulto , Infecções por Caliciviridae/virologia , Estudos de Casos e Controles , Criança , Fezes/virologia , Feminino , Humanos , Masculino , Montenegro/epidemiologia , Norovirus , Adulto Jovem
14.
Epidemiol Infect ; 136(1): 115-21, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17335633

RESUMO

The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management strategies using prospective, national surveillance of HUS and TTP, from 2003 to 2005 inclusive. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. Most cases of HUS were caused by verocytotoxin-producing Escherichia coli (VTEC), of which serotype O157 predominated, although other serotypes were identified. The list of predisposing factors for TTP was more varied although use of immunosuppressive agents and severe sepsis, were the most frequent precipitants. The study demonstrates that while differentiating between HUS and TTP is sometimes difficult, in most cases the two syndromes have quite different predisposing factors and clinical parameters, enabling clinical and epidemiological profiling for these disorders.


Assuntos
Síndrome Hemolítico-Urêmica/epidemiologia , Tempo de Internação/estatística & dados numéricos , Púrpura Trombocitopênica/epidemiologia , Adolescente , Adulto , Fatores Etários , Bases de Dados Factuais , Escherichia coli/isolamento & purificação , Escherichia coli/metabolismo , Escherichia coli O157/isolamento & purificação , Feminino , Síndrome Hemolítico-Urêmica/sangue , Síndrome Hemolítico-Urêmica/etiologia , Síndrome Hemolítico-Urêmica/microbiologia , Síndrome Hemolítico-Urêmica/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Vigilância da População , Estudos Prospectivos , Púrpura Trombocitopênica/sangue , Púrpura Trombocitopênica/etiologia , Púrpura Trombocitopênica/microbiologia , Púrpura Trombocitopênica/patologia , Escócia/epidemiologia , Fatores Sexuais , Toxinas Shiga/biossíntese , Inquéritos e Questionários
15.
Scott Med J ; 52(3): 5-7, 2007 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17874708

RESUMO

Scotland continues to report higher rates of infection with Escherichia coli O157 than elsewhere in the UK. Infection with E. coli O157 usually manifests as acute, afebrile, painful, bloody diarrhoea and is the commonest cause of Haemolytic Uraemic Syndrome (HUS), an important cause of childhood renal failure. In 1996 an outbreak of E. coli O157 infection in Central Scotland, resulted in over 500 cases and 17 deaths. Ten years on, high-profile outbreaks of E. coli O157 infection in Scotland still result in cases of HUS and fatalities. We sought to identify outcomes and describe pre-hospital clinical management strategies using prospective, national surveillance of paediatric HUS cases, from 2003 to 2006 inclusive. We recommend that children who present with acute, afebrile, and painful bloody diarrhoea be referred to hospital as early as possible for appropriate clinical management.


Assuntos
Infecções por Escherichia coli/terapia , Escherichia coli O157 , Criança , Humanos
16.
Vet Rec ; 157(22): 697-702, 2005 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-16311383

RESUMO

All the human and animal laboratory reports of zoonoses sent to Health Protection Scotland between 1993 and 2002 were identified. There were 24,946 reports from veterinary laboratories, and 94,718 (20 per cent) of the 468,214 reports from medical laboratories were considered to be zoonotic. The most common reports of zoonoses from people were Campylobacter, Salmonella, Cryptosporidium and Giardia species and Escherichia coli o157. The most common reports of zoonoses from animals were Salmonella, Cryptosporidium, Chlamydia and Campylobacter species and Mycobacterium avium paratuberculosis. For all the zoonoses in people, the National Health Service Board areas Borders, Dumfries and Galloway, Forth Valley, Grampian, Lanarkshire and Lothian had a higher than expected standardised incidence rate of infection, whereas Ayrshire and Arran, Fife, Greater Glasgow, Shetland, Tayside and Western Isles had a lower than expected rate. The organisms and diseases considered to be new and emerging were Rhodococcus species, Cyclospora cayetanensis, Leishmania species, Pneumocystis carinii (jiroveci) and bovine spongiform encephalopathy/variant Creutzfeldt-Jakob disease.


Assuntos
Doenças Transmissíveis/epidemiologia , Zoonoses , Animais , Humanos , Laboratórios/estatística & dados numéricos , Prontuários Médicos , Estudos Retrospectivos , Escócia/epidemiologia
18.
J Hosp Infect ; 61(3): 194-200, 2005 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16039013

RESUMO

Validation of surveillance data is necessary to ensure its scientific credibility, to identify methodological problems within the surveillance programme, to help increase compliance and participation in the surveillance programme, and to identify data quality issues at local level. Surgical site infection surveillance (SSIS) in Scotland has been implemented in collaboration between Health Protection Scotland (HPS) and staff in acute divisions in Scotland. A team at HPS carried out a study to validate the SSIS data reported to them. The aims of the validation study were: (i) to measure the completeness of the denominator data; (ii) to measure the accuracy of all SSIS data items reported to HPS; and (iii) to determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the SSIs reported to HPS against the SSIs validated as part of this study. The methodology utilized for validation of SSIS data was based on an evaluation research approach. The evaluation research approach involves a range of investigative activities, aimed at judging the worth of a programme or practice, and measures SSIS in terms of structure, process and outcome. The completeness of the denominator and the means of identifying eligible patients was identified. Descriptive information about how SSIS data were collected and managed at hospital level was collated, and the accuracy and completeness of the reported SSIS data were measured by case note review of selected cases. SSIS data from 27 hospitals in 15 acute divisions and one special health board were validated. The results indicated that a total of 91% of the procedures carried out (denominator) during a specified three-month period were reported to HPS. The case notes validated over 90% of records reported to HPS; however, there was variation in data quality between hospitals. The sensitivity, specificity, PPV and NPV of the SSIs reported to HPS were 96.7, 99.0, 94.6 and 99.4%, respectively. Where problems with data were identified at local level, hospitals have been offered guidance to improve their data. As a result of this study, HPS are confident that the Scottish SSIS data are reliable and robust.


Assuntos
Infecção Hospitalar/epidemiologia , Vigilância da População/métodos , Infecção da Ferida Cirúrgica/epidemiologia , Hospitais , Humanos , Escócia/epidemiologia , Sensibilidade e Especificidade , Procedimentos Cirúrgicos Operatórios/efeitos adversos
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