RESUMO
The synthesis of 3-substituted 2-phenyl-2,3-dihydro-4H-1,3,2-benzoxazaphosphorin-4-one 2-sulfide derivatives is described. The action of a series 2-oxide (1-6) and 2-sulfide (7-12) derivatives on the central nervous system has been evaluated. Compounds 1-4, 6, 7-10 exhibit neuroleptic activity. Derivatives of sulfide series act as antiserotoninergic drugs.
Assuntos
Sistema Nervoso Central/efeitos dos fármacos , Compostos Organofosforados/síntese química , Compostos Organofosforados/farmacologia , Animais , Antipsicóticos/síntese química , Antipsicóticos/farmacologia , Comportamento Animal/efeitos dos fármacos , Feminino , Masculino , Camundongos , Ratos , Ratos Wistar , Antagonistas da Serotonina/síntese química , Antagonistas da Serotonina/farmacologia , Relação Estrutura-AtividadeRESUMO
As a result of the reaction of salicylic amide with PCl3 and POCl3 2-chloro-2,3-dihydro-1,3,2-benzoxazaphosphorin-4-one (1) and its 2-oxide 2 are obtained. Compounds 1 and 2 form amides with amines in 2-position. Antineoplastic action of the derivatives containing the bis(2-chloroethyl)amide group in 2-position was found.
Assuntos
Antineoplásicos/síntese química , Compostos Organofosforados/síntese química , Animais , Antineoplásicos/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Feminino , Leucemia L1210/tratamento farmacológico , Espectroscopia de Ressonância Magnética , Masculino , Camundongos , Camundongos Endogâmicos DBA , Camundongos Endogâmicos , Compostos Organofosforados/farmacologia , Espectrofotometria InfravermelhoRESUMO
A series of N-derivatives of 2-phenyl-2,3-dihydro-1,3,2(lambda 5)- benzoxazaphosphoryl-4-one and 2-phenyl-10-methyl-3a-triethoxyphosphonio- 1H,2,3,9,10-tetrahydropyrrolo[3,4-b]([1,4]benzoxazepine-1,3,9-trio ne have been prepared. The pharmacological investigation of the above mentioned compounds shows antitumor action against leukaemia in the case of three N-derivatives.
Assuntos
Leucemia L1210/tratamento farmacológico , Compostos Organofosforados/farmacologia , Oxazepinas/farmacologia , Animais , Feminino , Dose Letal Mediana , Camundongos , Camundongos Endogâmicos DBA , Compostos Organofosforados/síntese química , Oxazepinas/síntese químicaRESUMO
Preparation of 2,3-dihydro-1,3,2-benzoxazaphosphorin-4-one derivatives and their 2-oxo derivatives is described. Compounds 1 and 12 have anticancer activity.