A Decade of Treatment of Canine Parvovirus in an Animal Shelter: A Retrospective Study.

Here, we present 11.5 years of monthly treatment statistics showing an overall intake of 5127 infected dogs between June 2008 and December 2019, as well as more detailed datasets from more recent, less protracted time periods for the examination of mortality risk, seasonality, and resource requirements in the mass treatment of canine parvovirus (CPV) in a private animal shelter. The total survival rate of animals during the study period was 86.6% (n = 4438/5127 dogs survived) with the probability of survival increasing to 96.7% after five days of treatment (with 80% of fatalities occurring in that period). A distinct parvovirus season peaking in May and June and troughing in August, September, December, and January was observed, which could have contributed as much as 41 animals peak-to-trough in the monthly population (with a potential, smaller season occurring in October). Low-weight and male animals were at higher risk for death, whereas age was not a significant contributing factor. Treatment time averaged 9.03 h of total care during a seven-day median treatment duration. These findings, taken together, demonstrate that canine parvovirus can be successfully treated in a sustainable manner within a shelter setting using a largely volunteer workforce.

Using Video Direct Observation to Assess Children's Physical Activity During Recess.

PURPOSE: Traditional direct observation cannot provide continuous, individual-level physical activity (PA) data throughout recess. This study piloted video direct observation to characterize children's recess PA overall and by sex and weight status. METHODS: Children (N = 23; 11 boys; 6 overweight; third to fifth grade) were recorded during 2 recess periods, coding for PA duration, intensity, location, and type. Duration of PA type and intensity across sex and weight status overall and between/within locations were assessed using 1- and 2-way analysis of variances. RESULTS: The field elicited more sedentary behavior (39% of time) and light PA (17%) and less moderate to vigorous PA (41%) compared with the fixed equipment (13%, 7%, and 71%, respectively) or the court (21%, 7%, and 68%, respectively). Boys engaged in significantly more vigorous-intensity activity on the court (35%) than girls (14%), whereas girls engaged in more moderate to vigorous PA on the fixed equipment (77% vs 61%) and field (46% vs 35%) than boys (all Ps > .05). PA type also differed by sex and weight status. CONCLUSION: Video direct observation was capable of detecting and characterizing children's entire recess PA while providing valuable context to the behavior. The authors confirmed previous findings that PA intensity was not uniform by schoolyard location and further differences exist by sex and weight status.

Preliminary Results of the Use of a Stabilized Hypochlorous Acid Solution in the Management of Ralstonia Pickettii Biofilm on Silicone Breast Implants.

BACKGROUND: Ralstonia Pickettii biofilms are associated with pocket infections following breast implant surgeries. Biofilm protects bacteria most topically applied antimicrobial irrigations. OBJECTIVES: To evaluate the effectiveness of four antimicrobial solutions on the planktonic form and established biofilm of Ralstonia Pickettii grown on 3 different types of silicone breast implants. METHODS: Time kill assays at clinical concentrations of chlorhexidine gluconate, povidone iodine, triple-antibiotic solution, and a 0.025% hypochlorous acid solution stabilized in amber glass were evaluated. Normal saline was the control. Three types of silicone implants, two with a textured surface and one smooth surface, were selected. Planktonic assays were performed after implants were soaked for one, five, 30, and 120 minute time points. Biofilm assays were performed after 5 and 120 minutes of implant soak time. Both tests evaluated cell-forming units (CFU/mL). RESULTS: Triple antibiotic solution had no effect on R. pickettii and was dropped from the study. Remaining solutions showed total kill of planktonic bacteria at one minute. Saline control showed no significant effect on biofilm as anticipated. Stabilized hypochlorous acid was the only solution tested capable of eradicating R. pickettii biofilm on all implant surfaces tested within the first five minute soak time. CONCLUSIONS: Noncytotoxic, 0.025% hypochlorous acid in normal saline, stabilized in amber glass, successfully eradicated Ralstonia pickettii in planktonic and mature biofilm on three types of silicone implants during initial five minute soak time and may be the preferred antimicrobial solution for pocket lavage. This preliminary study requires further investigation. Leaching and implant compatibility testing is currently in progress.

Knee scores change with length of follow-up after total knee arthroplasty.

Patients undergoing primary total knee arthroplasty (TKA) between 1989 and 1994 were evaluated preoperatively and postoperatively with the Knee Society scoring system at 3 time intervals: 1 to 2 years, 3 to 6 years, and more than 7 years. Knee prosthesis and functional scores improved statistically after TKA. At last follow-up evaluation, a statistically significant decline was found in functional knee scores that was related to an increase in numbers of patients in category C. Progression of arthritis at other sites, especially lumbar spine and hips, and cardiopulmonary problems were the most common cause of limited functional capacity. Women were found to have lower preoperative and postoperative functional scores. Patient weight, body mass index (BMI), and age at surgery showed no correlation with postoperative functional scores. The inclusion of functional categories would appear to be warranted when reporting long-term results of TKA.