Effect of Excipients on the Quality of Drug Formulation and Immediate Release of Generic Metformin HCl Tablets.

Generic medications are bioequivalent to brand-name medications, but the quality and purity of generic medications are still debatable. The aim of this study was to compare the generic product of metformin (MET) to its branded counterpart using pure MET powder as a reference. Quality control tablet assessment and in vitro evaluation of drug release were carried out in various pH media. Additionally, several analytical methods and thermal techniques were used, namely differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), and confocal Raman microscopy. The results showed a significant difference between the two products. In terms of friability assessment, mean resistance force, and tablet disintegration, the generic MET product showed significant weight loss, higher mean resistance force, longer disintegration time, and a slower rate of drug release. In addition, DSC and TGA showed that the generic product had the lowest melting point and the least weight loss compared to the branded product and pure powder. XRD and SEM demonstrated some changes in the crystallinity structure of the molecule particles for the generic product. Additionally, FTIR and confocal Raman revealed the same peaks and band shifts in all samples, but with differences in the intensity for the generic tablet only. The observed differences could be due to the use of different excipients in the generic product. The possibility of forming a eutectic mixture between the polymeric excipient and metformin in the generic tablet was presumed, which might be attributed to alterations in the physicochemical properties of the drug molecule in the generic product. In conclusion, using different excipients might have a significant effect on the physicochemical properties of drugs in generic formulations, leading to significant changes in drug release behavior.

Temperature Control of Yellow Photoluminescence from SiO2-Coated ZnO Nanocrystals.

In this study, we aimed to elucidate the effects of temperature on the photoluminescence from ZnO-SiO2 nanocomposite and to describe the preparation of SiO2-coated ZnO nanocrystals using a chemical precipitation method, as confirmed by Fourier transform infrared (FTIR) and powder X-ray diffraction analysis (XRD) techniques. Analyses using high-resolution transmission microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS), and electrophoretic light scattering (ELS) techniques showed that the new nanocomposite has an average size of 70 nm and 90% silica. Diffuse reflectance spectroscopy (DRS), photoluminescence (PL), and photoluminescence-excitation (PLE) measurements at different temperatures revealed two emission bands at 385 and 590 nm when the nanomaterials were excited at 325 nm. The UV and yellow emission bands were attributed to the radiative recombination and surface defects. The variable-temperature, time-resolved photoluminescence (VT-TRPL) measurements in the presence of SiO2 revealed the increase in the exciton lifetime values and the interplay of the thermally induced nonradiative recombination transfer of the excited-state population of the yellow emission via deep centers (DC). The results pave the way for more applications in photocatalysis and biomedical technology.

Microplastic Contamination of Chicken Meat and Fish through Plastic Cutting Boards.

Microplastic contamination was found in fish and chicken bought on the market, in food stores and in chain supermarkets in the Middle East with the contamination ranging from 0.03 ± 0.04 to 1.19 ± 0.72 particles per gram of meat in chicken and from 0.014 ± 0.024 to 2.6 ± 2.8 particles per gram in fish. Only one fish was found to be free of microplastic. The source of the microplastic was established to be the polythene-based plastic cutting board the food was cut on. More microplastic contamination was found in food cut from the bone than in cut fillets when the fillets themselves were prepared on surfaces other than plastic. Washing the fish and chicken before food preparation decreased but did not completely remove the microplastic contamination. The fate of the microplastic in grilled fish was studied. The mechanical properties of typical plastic cutting boards commercially used in the markets were investigated in the form of tensile, hardness, and wear tests. Overall, the plastic cutting boards showed similar wear rates.

Improving hand hygiene in a medical ward: a multifaceted approach.

BACKGROUND: Hand hygiene is a fundamental action which is simple, inexpensive and an effective tool in reducing hospital-acquired infections, yet compliance remains low in healthcare settings. In 2014, Changi General Hospital embarked on a pilot project to improve hand hygiene compliance in a pilot ward with the intention to eventually spread a multifaceted set of interventions hospital wide. METHODS: A before and after interventional study of a pilot project. Hand hygiene data collection was through direct observations by auditors using WHO monitoring standards and techniques based on the five-moment model. SETTING: A medical ward in an acute hospital in Singapore. RESULTS: Overall hand hygiene compliance improved from a median of 53% in 2015 to 80% by end of 2017. Hand hygiene compliance of doctors increased from 43% to 60% (p=0.00), nurses from 62% to 89% (p=0.014) and allied health staff from 67% to 83% (p=0.002). CONCLUSIONS: A multifaceted set of interventions developed by the project team was effective in improving hand hygiene compliance of doctors, nurses and allied health staff.

Plastic cutting boards as a source of microplastics in meat.

Plastic cutting boards were found to be the source of polythene microplastic contamination in cut meat commercially available at butchers and a supermarket chain in the Middle East, making them also a direct source of microplastic in wastewater. The mean size of the microplastic in the raw meat was 1279.2 ± 835.0 µm, but decreased when the meat was cooked or fried. The microplastic melted during both cooking and frying processes and recrystallised partially upon cooling. Washing the meat for a short time (10 seconds) before preparing it reduced the microplastic contamination insignificantly, and only extensive washing of the meat over longer periods of time (3 min) helped decrease the microplastic count to 0.07 MP/g meat. The composition of the cutting boards was analysed by FT-IR spectroscopy, differential scanning calorimetry and subjected to wear, tensile and hardness tests. From a 3D photo of a spent cutting board, it was calculatedthat 875 g polythene was lost from the cutting board at the end of its lifetime.

Approaching chronic cough.

Chronic cough is one of the most common reasons for referral to a respiratory physician. Although fatal complications are rare, it may cause considerable distress in the patient's daily life. Western and local data shows that in patients with a normal chest radiograph, the most common causes are postnasal drip syndrome, postinfectious cough, gastro-oesophageal reflux disease and cough variant asthma. Less common causes are the use of angiotensin-converting enzyme inhibitors, smoker's cough and nonasthmatic eosinophilic bronchitis. A detailed history-taking and physical examination will provide a diagnosis in most patients, even at the primary care level. Some cases may need further investigations or specialist referral for diagnosis.

Achieving optimal clinical outcomes in ultrasound-guided central venous catheterizations of the internal jugular vein after a simulation-based training program for novice learners.

INTRODUCTION: The aim of this study was to determine the number of ultrasound-guided (USG) central venous catheterization (CVC) of the internal jugular vein (IJV) residents had to perform, after a simulation-based training program, to achieve optimal clinical outcomes. METHODS: We conducted a single-center, prospective, observational study in the medical intensive care unit of a university-affiliated teaching hospital. Residents participated in a formal training program, consisting of a simulation-based workshop and 5 supervised USG CVC insertions on patients. Subsequent USG CVC of the IJV performed by residents during their rotation were assessed. Data on the overall success (OS), first pass success (FP) and mechanical complication (MC) rates were serially collected over 2 years, spanning 4 cohorts of residents. RESULTS: Thirty-two residents performed a total of 337 USG CVC of the IJV. Residents had previously performed an average of 9 CVC via the landmark technique. None had performed USG CVC before. Results showed that residents improved in their OS, FP, and MC rates as they performed more USG CVC. Residents needed to perform 7 USG CVCs to achieve optimal clinical outcomes of high OS and FP as well as low MC rates. There was a significant improvement in OS, FP, and MC rates for the eighth and subsequent USG CVCs compared with the first 7 USG CVCs (82% vs. 99% [P < 0.001], 70% vs. 92% [P < 0.001] and 11% vs. 0%, respectively). CONCLUSIONS: After a formal training program consisting of a simulation-based workshop and 5 supervised USG CVCs on critically ill adults, residents were able to achieve optimal clinical outcomes after performing 7 procedures.