Green Synthesis and Evaluation of the Biological Activity of New Dihydropyridine Derivatives.

AIMS AND OBJECTIVE: This work used silica-coated magnetic nanoparticles functionalized by iminodiacetic acid-cupper (Fe3O4@SiO2/IDA-Cu) to perform one-pot multicomponent reactions involving (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione (curcumine), primary amines, and activated acetylenic compounds in an aqueous medium at room temperature and to produce 1,4- dihydropyridine-2,3-dicarboxylate in high yields. Further research on this area uses diphenylpicrylhydrazine (DPPH) radical trapping to investigate the antioxidant properties of some generated 6,6´- methylene bis-1,4-dihydropyridine-2,3-dicarboxylates. Scholarly research now underway concentrates on examining the antibacterial characteristics of chemical substances that have been produced. MATERIALS AND METHODS: The reagents or solvents that the research team utilized were of analytical quality, which means that their physical and chemical characteristics were unaltered. The Ft-IR spectra of the prepared nanocatalysts and the synthesized 6,6´-methylene bis-1,4-dihydropyridine-2,3-dicarboxylates in a KBr medium were recorded using a Shimadzu IR-460 spectrometer. In addition, a Bruker DRX-400 AVANCE spectrometer was used to get the 1H and 13C NMR spectra of the produced compounds. To get the spectrum of the compounds generated, the spectrometer was calibrated to 400 MHz, the solvent was CDCl3, and the internal standard was TMS. It should be mentioned that the mass spectra of the generated compounds, which have an ionization capability of 70 eV, were obtained using the Finnigan MAT 8430 spectrometer. Using spectroscopy investigation, including X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and vibrating sample magnetometer (VSM), the synthetic catalyst Fe3O4@SiO2@IDA-Cu was approved for construction. Finnigan-MAT 8430 spectrometer was used to generate mass spectra of the chemicals that were created. To determine which element was present in the compounds that were formed, the Heraeus CHN-O-Rapid analyzer was used. RESULTS: The current study focused on creating new 6,6´-methylene bis-1,4-dihydropyridine-2,3- dicarboxylates 4 by combining curcumine 1, primary amines 2, and activated acetylenic compounds 3 in three-component processes. The reactions were performed in a water-based solution at normal ambient temperature, using Fe3O4@SiO2@IDA-Cu as a nanocatalyst that may be used multiple times. The findings demonstrated that the synthesized compounds displayed a significant antioxidant potential in comparison to conventional antioxidants. Furthermore, the produced compounds were evaluated for their antibacterial efficacy against both gram-positive and gram-negative bacteria. CONCLUSION: In conclusion, the multicomponent reactions involving curcumin, primary amines, and activated acetylenic chemicals were investigated in a water-based setting at normal room temperature. The reactions were carried out using a new type of catalyst called Fe3O4@SiO2@IDA-Cu, which is an organometallic nanocatalyst. This led to the creation of new versions of 6,6´-methylene bis-1,4-dihydropyridine-2,3- dicarboxylates with antioxidants and antibacterial activity.

Response surface methodology, and artificial neural network model for removal of textile dye Reactive Yellow 105 from wastewater using Zeolitic Imidazolate-67 modified by Fe3O4 nanoparticles.

The applicability of Zeolitic Imidazolate-67, Modified by Fe3O4 Nanoparticles, was studied for removing textile dye Reactive yellow 105 from wastewater by adsorption method using response surface methodology (RSM). For the adsorption characterization of the adsorbent used in HE-4G dye adsorption, BET, FTIR, XRD, and SEM analyses were performed. The impacts of variables, including initial HE-4G dye concentration (X1), pH (X2), adsorbent dosage (X3), and sonication time (X4), the highest removal efficiency as 98%, 10 mg/L initial concentration, pH 6, 0.025 g adsorbent dosage, and 6.0 min time respectively. Adsorption equilibrium and kinetic data it, that data were for the Langmuir isotherm, pseudo-second-order kinetics, and maximum adsorption capacity (105.0 mg/g), respectively. Thermodynamic parameters indicated HE-4G dye adsorption is feasible, spontaneous and exothermic. Promising treatment capabilities of the ZIF-67-Fe3O4NPs have been during the comparative adsorption removal of HE-4G dye from DI water against spiked natural water samples and synthetic Na+, K+, Ca2+, and Mg2+ solutions. The observed outcome is the suitability of the artificial neural network model as a tool for mean square error, (MSEANN = 0.53, and R2 = 0.9926) for removing HE-4G dye. Results that ZIF-67-Fe3O4NPs, like being recyclable, and cost-efficient made it a promising absorbent for wastewater.

Resonance Rayleigh scattering technique-using chitosan-capped gold nanoparticles, approaches spectrofluorimetric method for determination of Bentazone residual in water samples.

In this study, a resonance Rayleigh scattering technique-based sensing method for detecting Bentazone residual in water samples has been developed. This technique was carried out using chitosan-capped gold nanoparticles with a spectrofluorimetric method. Experimental results revealed that the developed method could allow the detection of Bentazone residual as low as a concentration of 0.02 ng mL-1 within 50-sec time. Overall results confirmed the very low detection limit for measuring the Bentazone. The chitosan-capped gold nanoparticles as an excellent sensor were applied to measure and analyze Bentazone in water samples.

This article developed a resonance Rayleigh scattering technique-based sensing method for the detection of bentazone residual in water samples. This technique was carried out using chitosan-capped gold nanoparticles with spectrofluorimetric method. Because, Chitosan-capped AuNPs have exciting features, such as resonance Rayleigh scattering (RRS).

Design of fluorescent method for sensing toxic diazinon in water samples using PbS quantum dots-based gelatin.

In this current article, a chemical sensor was synthesized PbS functionalized with gelatin quantum dots for toxic diazinon. The measure of toxic diazinon was performed using concentration 0.5 µM, PbS quantum dot-gelatin nanocomposites sensor, pH 6, and time 50 s, wavelength 300 nm, in phosphate buffer solution. Under the optimum conditions, the detection limit linear range was obtained (0.01-20.0 µg L-1). The standard deviation of less than (1.0%), and detection limits (3S/m) of the method (0.01 µg L-1) and quantification (LOQ) of (0.099 µg L-1), for determination of toxic diazinon, was obtained. The observed outcomes confirmed the suitability recovery and a very low detection limit for measuring the toxic diazinon. The Chemical PbS Quantum Dot-Gelatin nanocomposites sensor as excellent sensor was applied to measure and analyze residue toxic diazinon in water samples.

Homogeneous Liquid-Liquid Microextraction for Determination of Organophosphorus Pesticides in Environmental Water Samples Prior to Gas Chromatography-Flame Photometric Detection.

In this study, homogeneous liquid-liquid microextraction (HLLME) was developed for preconcentration and extraction of 15 organophosphorus pesticides (OPPs) from water samples coupling with gas chromatography followed by a flame photometric detector (HLLME-GC-FPD). In this method, OPPs were extracted by the homogeneous phase in a ternary solvent system (water/acetic acid/chloroform). The homogeneous solution was excluded by the addition of sodium hydroxide as a phase separator reagent and a cloudy solution was formed. After centrifugation (3 min at 5,000 rpm), the fine particles of extraction solvent (chloroform) were sedimented at the bottom of the conical test tube (10.0 ± 0.5 µL). Furthermore, 0.5 µL of the sedimented phase was injected into the GC for separation and determination of OPPs. Optimal results were obtained under the following conditions: volume of the extracting solvent (chloroform), 53 µL; volume of the consolute solvent (acetic acid), 0.76 mL and concentration of sodium hydroxide, 40% (w/v). Under the optimum conditions, the enrichment factors of (260-665), the extraction percent of 75.8-104%, the dynamic linear range of 0.03-300 µg L(-1) and the limits of detection of 0.004-0.03 µg L(-1) were obtained for the OPPs. This method was successfully applied for the extraction and determination of the OPPs in environmental water samples.