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J Integr Plant Biol ; 62(5): 601-613, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31081586

RESUMO

Polyamines are small aliphatic amines found in almost all organisms, ranging from bacteria to plants and animals. In most plants, putrescine, the metabolic precursor for longer polyamines, such as spermidine and spermine, is produced from arginine, with either agmatine or ornithine as intermediates. Here we show that Arabidopsis thaliana (Arabidopsis) arginine decarboxylase 1 (ADC1), one of the two known arginine decarboxylases in Arabidopsis, not only synthesizes agmatine from arginine, but also converts Nδ -acetylornithine to N-acetylputrescine. Phylogenetic analyses indicate that duplication and neofunctionalization of ADC1 and NATA1, the enzymes that synthesize Nδ -acetylornithine in Arabidopsis, co-occur in a small number of related species in the Brassicaceae. Unlike ADC2, which is localized in the chloroplasts, ADC1 is in the endoplasmic reticulum together with NATA1, an indication that these two enzymes have access to the same substrate pool. Together, these results are consistent with a model whereby NATA1 and ADC1 together provide a pathway for the synthesis of N-acetylputrescine in Arabidopsis.


Assuntos
Proteínas de Arabidopsis/metabolismo , Arabidopsis/metabolismo , Carboxiliases/metabolismo , Acetiltransferases/genética , Acetiltransferases/metabolismo , Arabidopsis/genética , Proteínas de Arabidopsis/genética , Carboxiliases/genética , Retículo Endoplasmático/metabolismo , Regulação da Expressão Gênica de Plantas , Oxigenases/genética , Oxigenases/metabolismo , Filogenia , Putrescina/análogos & derivados , Putrescina/metabolismo
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