RESUMO
Effective ways to reduce sedentary behaviour in adolescents are needed to mitigate the risk of chronic disease and poor mental health. Organised sport participation is the most practiced physical activity during adolescence. However, the influence sport participation has on sedentary behaviours remains unclear. This study investigated the associations between sport participation, total and domain-specific sedentary behaviour and physical activity during the transition from secondary school to university. A 3-year longitudinal survey followed Spanish secondary school students (n = 113) to their first year of university. Generalized linear models, adjusted by gender and year, assessed the relationships between sport participation, total and domain-specific sedentary behaviour and physical activity. Compared with non-sport participants, teenagers who played individual sports from baseline during secondary school spent significantly less total time sitting (- 110.5 min/day at weekends), watching television (- 18.7 min/day at weekends) or using the computer for leisure (- 37.4 min/day weekdays). Those who played team sports from baseline at secondary school spent less time sitting (- 126.4 min/day at weekends) or socialising (- 37 min/day at weekends)Conclusion: From secondary school to university, sport participation-based interventions might be an effective strategy to reduce sitting time spent on some domain-specific behaviours. Promoting sports could reduce the rise of sedentary behaviour during adolescence, a stage where sedentary behaviour evolves. What is Known: ⢠Sitting too much and for too long is an important risk factor during adolescence. ⢠Replacing adolescent's sedentary time with moderate-to-vigorous physical activity has been associated with a better quality of life. What is New: ⢠Playing sport is associated with spending less time in total SB on the transition from high school to college. ⢠Not all SB domains are linked to sport participation with associations differing from whether participants played individual or team sports.
Assuntos
Comportamento Sedentário , Universidades , Adolescente , Humanos , Qualidade de Vida , Instituições Acadêmicas , EstudantesRESUMO
In ecology and evolution, entropic methods are now used widely and increasingly frequently. Their use can be traced back to Ramon Margalef's first attempt 70 years ago to use log-series to quantify ecological diversity, including searching for ecologically meaningful groupings within a large assemblage, which we now call the gamma level. The same year, Shannon and Weaver published a generally accessible form of Shannon's work on information theory, including the measure that we now call Shannon-Wiener entropy. Margalef seized on that measure and soon proposed that ecologists should use the Shannon-Weiner index to evaluate diversity, including assessing local (alpha) diversity and differentiation between localities (beta). He also discussed relating this measure to environmental variables and ecosystem processes such as succession. Over the subsequent decades, he enthusiastically expanded upon his initial suggestions. Finally, 2019 also would have been Margalef's 100th birthday.
RESUMO
HLA-B*44:203 shows one nucleotide difference to B*44:03:01 at codon 171 (TAC>CAC, Y171>H171).
Assuntos
Alelos , Substituição de Aminoácidos , Antígenos HLA-B/genética , Polimorfismo de Nucleotídeo Único , Sequência de Bases , Códon , Éxons , Sangue Fetal/química , Sangue Fetal/imunologia , Antígenos HLA-B/classificação , Antígenos HLA-B/imunologia , Teste de Histocompatibilidade , Humanos , Dados de Sequência Molecular , Isoformas de Proteínas/classificação , Isoformas de Proteínas/genética , Isoformas de Proteínas/imunologia , Alinhamento de Sequência , EspanhaRESUMO
HLA-B*08:108 shows one nucleotide difference regarding B*08:01:01 at codon 109 (CTC>TTC, L109>F109).
Assuntos
Alelos , Éxons , Antígeno HLA-B8/genética , Polimorfismo de Nucleotídeo Único , Sequência de Bases , Transplante de Medula Óssea , Códon , Antígeno HLA-B8/imunologia , Teste de Histocompatibilidade , Humanos , Dados de Sequência Molecular , Alinhamento de Sequência , Análise de Sequência de DNA , Doadores de Tecidos , População BrancaRESUMO
Two novels alleles, HLA-A*01:128 and HLA-C*05:88 are characterized.
Assuntos
Alelos , Antígenos HLA-A/genética , Antígenos HLA-C/genética , Sequência de Aminoácidos , Substituição de Aminoácidos , Transplante de Medula Óssea , Códon , Antígenos HLA-A/imunologia , Antígenos HLA-C/imunologia , Teste de Histocompatibilidade , Humanos , Dados de Sequência Molecular , Mutação , Alinhamento de Sequência , Análise de Sequência de DNA , Espanha , Doadores de TecidosRESUMO
Two novel HLA-B alleles were characterized. HLA-B*37:34 shows two nucleotide differences regarding B*37:10 at codons 79 (CGC>CGG) and 80 (ACC>ATC), resulting in one amino acid replacement at position 80 (T>I). HLA-B*44:152 differs from B*44:02:01 in one nucleotide at codon 81 (GCG>ACG) giving rise to a leucine to threonine substitution at position 81.
Assuntos
Antígeno HLA-B37/genética , Antígeno HLA-B44/genética , Alelos , Sequência de Aminoácidos , Substituição de Aminoácidos , Técnicas de Genotipagem , Teste de Histocompatibilidade , Humanos , Dados de Sequência Molecular , Mutação Puntual , Polimorfismo de Nucleotídeo Único , Homologia de Sequência de AminoácidosRESUMO
A*33:49 has one nucleotide change regarding A*33:01:01 at exon 3, producing an amino acid replacement at codon 97, M97 to I97.
Assuntos
Alelos , Éxons/genética , Antígenos HLA-A/genética , Sequência de Aminoácidos , Substituição de Aminoácidos/genética , Apresentação de Antígeno/genética , Transplante de Células-Tronco de Sangue do Cordão Umbilical , Teste de Histocompatibilidade , Humanos , Imunidade/genética , Dados de Sequência Molecular , Mutação/genética , Polimorfismo de Nucleotídeo Único , Análise de Sequência de DNA , EspanhaRESUMO
DRB1*04:98 shows four nucleotide changes regarding DRB1*04:01:01, resulting in two amino acids replacement at positions A73G and A74R.
Assuntos
Alelos , Substituição de Aminoácidos , Cadeias HLA-DRB1/genética , Mutação , Análise Mutacional de DNA , Humanos , EspanhaAssuntos
Antígenos CD34/imunologia , Antígenos/imunologia , Células Dendríticas/imunologia , Leucemia Aguda Bifenotípica/imunologia , Proteoglicanas/imunologia , Linhagem Celular Tumoral , Citometria de Fluxo , Histona-Lisina N-Metiltransferase , Humanos , Imunofenotipagem , Leucemia Aguda Bifenotípica/patologia , Proteína de Leucina Linfoide-Mieloide/genéticaRESUMO
Human leukocyte antigen (HLA) class I sequencing typing of a cord blood unit obtained from an Ecuadorian family showed the presence of the recently described A*6836 and B*3922 alleles. Sequences of these two antigens were confirmed and completed. Additionally, a new HLA-B allele, B*3579, was found in the same family, showing a difference of one amino acid residue at position 211 (Ala > Glu) compared with B*3543.
Assuntos
Alelos , Antígenos HLA-A/genética , Antígeno HLA-B35/genética , Análise de Sequência de DNA , Adulto , Sequência de Aminoácidos , Sequência de Bases , Equador , Feminino , Humanos , Recém-Nascido , Dados de Sequência MolecularRESUMO
HLA-B*4077 differs from B*400101, B*4036, and B*401401 in five, four, and three nucleotides, respectively. However, amino acid alignment would indicate a closer relationship with B*4036 allele, showing a single amino acid replacement at codon 131 (R>S).
Assuntos
Alelos , Antígenos HLA-B/genética , Adulto , Sequência de Bases , Humanos , Dados de Sequência Molecular , Mutação Puntual , Polimorfismo de Nucleotídeo ÚnicoRESUMO
HLA-B*9523 differs from B*1591 and B*1503 in point nucleotide mutations at codon 167 (TCG --> TGG) and 152 (GAG --> GTG), respectively.
Assuntos
Antígenos HLA-B/genética , Alelos , Sequência de Bases , DNA/genética , Sangue Fetal/imunologia , Humanos , Recém-Nascido , Dados de Sequência Molecular , Polimorfismo Genético , Homologia de Sequência do Ácido Nucleico , Espanha , População Branca/genéticaRESUMO
DRB1*1375 differs from DRB1*1304 allele in a point nucleotide mutation at codon 67 (ATC-->TTC), which produces an amino acid residue change from I to F.
Assuntos
Antígenos HLA-DR/genética , Alelos , Sequência de Aminoácidos , Sequência de Bases , Cadeias HLA-DRB1 , Humanos , Leucócitos/imunologia , Dados de Sequência MolecularAssuntos
Sangue Fetal , Transplante de Células-Tronco Hematopoéticas , Adulto , Feminino , Humanos , Recém-Nascido , Masculino , GravidezRESUMO
The development of the human umbilical cord blood transplants with hematopoietic repopulating cells has enabled some problems associated with bone marrow transplants to be solved. Frozen umbilical cord blood banks should facilitate the finding of suitable stem cell donors. However, further experience is necessary to develop the optimal method for collection, separation, storage and cryopreservation of umbilical cord blood. We report our experience in the organization of a Cord Blood Bank.