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1.
Nature ; 575(7783): 459-463, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31748725

RESUMO

Long-duration γ-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterized by an initial phase of bright and highly variable radiation in the kiloelectronvolt-to-megaelectronvolt band, which is probably produced within the jet and lasts from milliseconds to minutes, known as the prompt emission1,2. Subsequently, the interaction of the jet with the surrounding medium generates shock waves that are responsible for the afterglow emission, which lasts from days to months and occurs over a broad energy range from the radio to the gigaelectronvolt bands1-6. The afterglow emission is generally well explained as synchrotron radiation emitted by electrons accelerated by the external shock7-9. Recently, intense long-lasting emission between 0.2 and 1 teraelectronvolts was observed from GRB 190114C10,11. Here we report multi-frequency observations of GRB 190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from 5 × 10-6 to 1012 electronvolts. We find that the broadband spectral energy distribution is double-peaked, with the teraelectronvolt emission constituting a distinct spectral component with power comparable to the synchrotron component. This component is associated with the afterglow and is satisfactorily explained by inverse Compton up-scattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed teraelectronvolt component are typical for GRBs, supporting the possibility that inverse Compton emission is commonly produced in GRBs.

2.
Nature ; 424(6950): 749-51, 2003 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-12917676

RESUMO

Gamma-ray bursts are among the most powerful events in nature. These events release most of their energy as photons with energies in the range from 30 keV to a few MeV, with a smaller fraction of the energy radiated in radio, optical, and soft X-ray afterglows. The data are in general agreement with a relativistic shock model, where the prompt and afterglow emissions correspond to synchrotron radiation from shock-accelerated electrons. Here we report an observation of a high-energy (multi-MeV) spectral component in the burst of 17 October 1994 that is distinct from the previously observed lower-energy gamma-ray component. The flux of the high-energy component decays more slowly and its fluence is greater than the lower-energy component; it is described by a power law of differential photon number index approximately -1 up to about 200 MeV. This observation is difficult to explain with the standard synchrotron shock model, suggesting the presence of new phenomena such as a different non-thermal electron process, or the interaction of relativistic protons with photons at the source.

3.
J Reprod Fertil ; 73(2): 369-78, 1985 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-3921702

RESUMO

The patterns of LH and FSH secretion were measured in 4 experimental groups of Finnish Landrace and Scottish Blackface ewes: long-term (18 months) ovariectomized ewes (Group 1), long-term ovariectomized ewes with an oestradiol implant, which has been shown to produce peripheral levels of approximately 5 pg/ml (Group 2), long-term ovariectomized ewes with an oestradiol implant for 18 months which was subsequently removed (surgery on Day 0) (Group 3) and short-term ovariectomized ewes (surgery on Day 0) (Group 4). LH and FSH concentrations were monitored in all groups at approximately weekly intervals, before and after Day 0. Finnish Landrace ewes in Groups 1, 2 and 3 had significantly higher mean FSH concentrations than did Scottish Blackface ewes (P less than 0.01). FSH and LH concentrations increased significantly in Groups 3 and 4, but values in Group 4 were significantly lower (P less than 0.01) than those in Group 1 ewes even up to 30 days after ovariectomy. In Group 3, LH concentrations increased to levels similar to those in Group 1. The pattern of LH release was, however, significantly different, with a lower LH pulse frequency (P less than 0.05), but higher pulse amplitude (P less than 0.05). This difference was maintained at least until 28 days after implant removal. We suggest that removal of negative feedback by ovariectomy demonstrates an underlying breed difference in the pattern of FSH secretion and that ovarian factors other than oestradiol are also involved in the negative-feedback control of hypothalamic/pituitary gland function. Furthermore, negative-feedback effects can be maintained for long periods, at least 28 days, after ovariectomy or oestradiol implant removal.


Assuntos
Anestro , Estro , Hormônio Foliculoestimulante/metabolismo , Hormônio Luteinizante/metabolismo , Estações do Ano , Animais , Castração , Implantes de Medicamento , Estradiol/farmacologia , Retroalimentação , Feminino , Hormônio Foliculoestimulante/sangue , Hormônio Luteinizante/sangue , Gravidez , Taxa Secretória/efeitos dos fármacos , Ovinos , Fatores de Tempo
4.
J Reprod Fertil ; 59(1): 73-8, 1980 May.
Artigo em Inglês | MEDLINE | ID: mdl-6772780

RESUMO

The effects of pharmacological reduction of the high plasma prolactin concentration typical of seasonal anoestrus in sheep were assessed with respect to positive feedback of oestrogen on LH release, ovulation, and progesterone secretion. Treatment of 16 Scottish Blackface ewes with 1 mg bromocriptine, i.m. twice daily for 12 days, reduced prolactin concentrations in peripheral plasma from 64 +/- 10 ng/ml before treatment to < 4 ng/ml. This treatment had no effect on the proportion of ewes discharging LH and FSH in response to 12.5 microgram oestradiol benzoate (3/8 before compared with 5/16 during treatment) or the proportion of ewes ovulating in response to oestrogen treatment. Plasma progesterone concentrations remained low even in ovulating ewes. It is concluded that treatment with bromocriptine alone is unlikely to restore oestrous cycles to ewes in seasonal anoestrus.


Assuntos
Corpo Lúteo/fisiologia , Estrogênios/fisiologia , Hormônio Foliculoestimulante/sangue , Hormônio Luteinizante/sangue , Anestro , Animais , Bromocriptina/farmacologia , Corpo Lúteo/efeitos dos fármacos , Depressão Química , Retroalimentação , Feminino , Ovulação , Gravidez , Progesterona/sangue , Prolactina/metabolismo , Ovinos
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