1.
Bioorg Med Chem Lett
; 16(18): 4834-8, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16824756
RESUMO
A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Herein we report the structure-activity relationships (SARs) of this novel class of dihydropyrone-containing compounds that show potent inhibitory activities against the HCV RNA polymerase in biochemical assays.