[A peripheral biological marker of organicity. Chromosome mosaic anomalies in general psychiatry]. / Un marqueur biologique périphérique d'organicité. Les anomalies chromosomiales en mosaïques en psychiatrie générale.

During February 1979 to December 1982 we studied the karyotype of 706 psychiatric adult patients without making a clinical selection. We found a chromosomial mosaïc aberration in 37 cases, concerning one leukocyte mitosis for ten studied cells : so a proportion of 5.2% cases. There do not exist statistics concerning the general population's mosaïc aberrations but in the same population the proportion of the homogeneous aberrations is near 0.5%, so 10 times lower than the proportion that we observed. The largest number of aberrations found concern the gonosomes, essentially some monosomics 45,XO or some trisomics 47,3X, among women who present a maniac depressive psychosis or another type of depression.

[Lewis-negative blood group. Definite frequency, probable prognostic value in adult psychiatry]. / Groupe sanguin Lewis négatif. Fréquence certaine, valeur pronostique probable en psychiatrie de l'adulte.

The negative Lewis blood type is meaningfully more frequent with our psychiatric patients than with the general population. The theoretical interest of this fact is certain for the reason of two particularities of this blood type. It is not genetically and definitely determined at birth: the absence of passing over negativity through positivity seems to constitute a factor in favour of the blossoming of a psychiatric pathology. It is in connection with the secretory aptitude of some cells: this fact opens some perspectives for the comprehension of the deficits in the neurotransmitters. The application of theory will be confirmed by others statistics. But it indeed appears that the control of the chemiotherapy is more difficult with the negative Lewis blood type patients.