1.
Bioorg Med Chem Lett
; 15(16): 3787-90, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16002291
RESUMO
A new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Modeling studies using a known MMP-12 crystal structure identified a new interaction mode for these new MMP-12 inhibitors. Further optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 and which was co-crystallized with MMP-12.