RESUMO
BACKGROUND: To assess the incidence and economic burden of rotavirus diarrhea and the potential cost-effectiveness of a rotavirus immunization program in rural Zhengding County in Hebei Province, China. METHODS: Population-based surveillance was conducted during the peak season for diarrhea among children who were <5 years of age in Zhengding County from 14 October 2004 through 19 January 2005. The cost of illness was measured from the perspectives of both patient and society. A decision-analytic model was applied to the cost-effectiveness analysis using real data derived from surveillance and from a cost-of-illness study. RESULTS: During the surveillance period, 500 episodes of diarrhea were registered. Of these 500 episodes, 125 (25%) occurred in patients who were positive for rotavirus. Of these 125 episodes, 63 (50%) occurred in patients who were hospitalized. The overall incidence rate of rotavirus infection was 61.4 cases per 1000 children per year during the 14-week epidemic season. For a Chinese cohort of 5000 newborns, a universal rotavirus immunization program would prevent 1764 cases of rotavirus diarrhea, averting 882 hospitalizations of patients Assuntos
Programas de Imunização/economia
, Infecções por Rotavirus/economia
, Infecções por Rotavirus/prevenção & controle
, Vacinas contra Rotavirus/economia
, Vacinas contra Rotavirus/imunologia
, Pré-Escolar
, China
, Análise Custo-Benefício
, Diarreia/economia
, Diarreia/epidemiologia
, Diarreia/prevenção & controle
, Diarreia/virologia
, Feminino
, Humanos
, Incidência
, Lactente
, Recém-Nascido
, Masculino
, Infecções por Rotavirus/epidemiologia
, População Rural