RESUMO
The development of nanocomposite hydrogel dressings with adhesion and superior mechanical and wound infection inhibition characteristics for wound repair and skin regeneration is urgently needed for clinical applications. In this study, the adhesive piezoelectric antibacterial hydrogels with high expansibility, degradability, and adjustable rheological properties were innovatively prepared by a simple assembly process with carboxymethyl chitosan (CMCS), tannic acid (TA), carbomer (CBM), and piezoelectric FeWO4 nanorods. As an exogenous mechanical wave, ultrasound can trigger the piezoelectric effect of FeWO4 and then effectively augment the generation of reactive oxygen species, exhibiting a superior antibacterial efficiency and preventing wound infection. In vitro and in vivo results have demonstrated that piezoelectric hydrogels can accelerate full-thickness skin wound healing in bacteria-infected mice by skin regeneration, inhibiting inflammatory response, increasing collagen deposition, and promoting angiogenesis. Such a discovery provides a representative paradigm for the rational design of piezoelectric hydrogel and effectively serves antibacterial and wound dressing fields.
Assuntos
Hidrogéis , Infecção dos Ferimentos , Camundongos , Animais , Hidrogéis/farmacologia , Cicatrização , Pele , Antibacterianos/farmacologiaRESUMO
Objective: This study aimed to provide scientific management methods to prevent nosocomial infection based on the systematical evaluation of the effect of operating room nursing management on nosocomial infection in orthopedic surgery. Methods: PubMed, Web of Science, Embase, China National Knowledge Internet, and Wanfang Databases were systematically searched for relevant studies published from 2013 to 2020. In this meta-analysis, comprehensive estimates of effect size estimates and 95% confidence intervals (CIs) for nursing satisfaction and incidence of infection were obtained. Results: Twenty studies with 2962 orthopedic patients were included in the meta-analysis. The experimental group received operating room nursing management while the routine nursing management was given for the control group. Meta-results showed that, in comparison with the control group, the nursing satisfaction in the experimental group was increased (OR = 6.22, 95% CI: 4.63-8.35, P < 0.001), while the incidence of infection was reduced (OR = 0.20, 95% CI: 0.15-0.28, P < 0.001), and the differences had statistical significance. Conclusions: Operating room nursing management could reduce the incidence of infection while prevent nosocomial infection in orthopedic surgery, which could be utilized to guide the hospital management.
Assuntos
Infecção Hospitalar , Enfermagem de Centro Cirúrgico , Procedimentos Ortopédicos , Ortopedia , China , Infecção Hospitalar/prevenção & controle , HumanosRESUMO
Psoriasis is a systemic immunemediated inflammatory disease characterized by uncontrolled keratinocyte proliferation and poor differentiation. Cinnamaldehyde (CIN) has been shown to inhibit the proliferation and inflammatory response of primary and immortalized immune cells. However, to the best of our knowledge, the role of CIN in the progression of psoriasis remains unclear. Therefore, the present study aimed to investigate the biological role of CIN in psoriasis. To mimic abnormal proliferation and differentiation in keratinocytes in vitro, normal human epidermal keratinocytes (NHEKs) were stimulated with M5 (IL1α, IL17A, IL22, oncostatin M and TNFα). The viability and proliferation of NHEKs were analyzed using Cell Counting Kit8 and 5Ethynyl2'deoxyuridine assays, respectively. Western blotting was used to analyze the expression levels of keratin 1, filaggrin and loricrin in NHEKs. The results of the present study revealed that CIN significantly inhibited the proliferation and cell cycle progression, and promoted the differentiation of M5stimulated NHEKs. CIN also markedly attenuated the extent of oxidative stressinduced damage in M5stimulated NHEKs. Moreover, CIN ameliorated M5induced inflammatory injury in NHEKs, as evidenced by the decreased levels of multiple inflammatory factors. Furthermore, CIN notably downregulated the expression levels of phosphorylated (p)inhibitor of NFκB, pp65 and pJNK in M5stimulated NHEKs. In conclusion, the present data suggested that CIN may protect NHEKs against M5induced hyperproliferation and inflammatory injury via inhibition of NFκB and JNK signaling pathways. These results provide a novel insight on the role of CIN in psoriasis.