RESUMO
The authors describe a case of severe CMV retinitis in a young adult AIDS patient who recovered following first a course of ganciclovir and then HAART. Six months after the initial episode while still under successful HAART, the patient developed an acute episode of retinitis despite a persistent significant improvement in the immunological picture and a very low level of CMV reactivation. The acute episode can be related to an enhanced individual reactivity to minor CMV replication.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/etiologia , Terapia Antirretroviral de Alta Atividade , Retinite por Citomegalovirus/etiologia , Infecções por HIV/tratamento farmacológico , Organofosfonatos , Doença Aguda , Adulto , Antivirais/uso terapêutico , Contagem de Linfócito CD4 , Cidofovir , Citosina/análogos & derivados , Citosina/uso terapêutico , Quimioterapia Combinada , Ganciclovir/uso terapêutico , Humanos , Indinavir/administração & dosagem , Lamivudina/administração & dosagem , Masculino , Compostos Organofosforados/uso terapêutico , Zidovudina/administração & dosagemRESUMO
HHV-8 (Human Herpesvirus 8) is a human lymphotropic and transforming virus closely associated to the development of Kaposis's sarcoma, Castleman's disease and Primary Effusion Lymphoma among immunosuppressed patients. Prevalence of infection varies according to different geographic area and to ethnic group or to risk factors. No effective treatments are available at present.