[Chronic pelvic pain syndrome in women: diagnostic and therapeutic aspects].

Chronic pelvic pain syndrome (PPS) refers to pain of three to six months duration (or longer) that occurs below the umbilicus. PPS is considered a form of chronic regional pain syndrome or functional somatic pain syndrome. Multimodal ollaborative and patient-centered approach is critical component of treatment for women with CPPS. The current review encompasses the linical manifestations and therapeutic interventions for CPPS - a yet to be defined problem.

[Age-related changes in the immune system and cognitive disorders in vascular dementia and Alzheimer's disease]. / Vozrastnye izmeneniya immunnoi sistemy i vozniknovenie kognitivnykh rasstroistv pri sosudistoi dementsii i bolezni Al'tsgeimera.

The immune mechanisms of cognitive impairment are considered. Various causal relationships of the development of immune and neurodegenerative disorders, including vascular dementia (VD) and Alzheimer's disease (AD), are analyzed. It has been shown that age-related adaptive restructuring of immunity leads to the fact that lymphocytic immunity as a whole begins to work in an intermediate metastable state. The dominant role of immune factors in the development of VD and AD is highlighted. It is concluded that the pathogenesis of neurodegenerative diseases is associated with a decrease in antibody activity. The number of cytokines in aging animals is significantly reduced which leads to a decrease in the level of the immune response of the cell.