RESULTS AND ADVERSE OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION: HISTORICAL COHORT STUDY.

Percutaneous coronary intervention (PCI) is developed in Kazakhstan very quickly for many years. But there is no information about outcomes of PCI. The objective of this study was to analyze the outcomes after percutaneous coronary interventions in two regions Kazakhstan during 2012-2018 years. This registry-based historical cohort study obtained data on all patients who underwent PCI in East Kazakhstan and Pavlodar regions of Kazakhstan. Data are presented as the means ± standard deviation or as frequencies and percentage. The incidence rates were calculated as the number of cases per 100000 person-years of follow-up and 95% CI. A multivariate logistic regression analysis was utilized to find the independent predictors for in-hospital mortality. A total of 11931 subjects were undergone of PCI. Of these, 8349 (70,0%) were male, 3582 (30,0%) were female. A total of 320 patients (2,7%) died after the PCI during in-hospital period. Patients who died in-hospital period were predominantly male (55,9%), mean age 67,8 (9,71) years. Mortality rate was higher in women, and patients who were sent by other medical Institution and in patients with diagnose cerebral infarction. In-hospital mortality rate was higher in women than in men and in patients aged 70 years and elder. Independent predictors of in-hospital mortality for patients were age, gender, way of hospitalization, diagnose.

PERINATAL CARE INDICATORS IN ALMATY, KAZAKHSTAN FOR 2013-2017: A CROSS-SECTIONAL STUDY.

Protection of maternity and child health is of great medical and social importance. Provision of medical care to women and children in Kazakhstan is the major task for state policy. Still, the data on epidemiological indicators of perinatal care in Kazakhstan are rather limited. This study was aimed at assessment of perinatal care indicators in Almaty, Kazakhstan Republic, over the period from 2013 to 2017. The data on demographic characteristics of study population were obtained from online platform of the Republican Center for Health Development. The analysis of perinatal indicators was carried-out on the basis of statistical reporting form No. 32. We relied on the standard statistical formulas to calculate epidemiological indicators. All statistical tests were performed in SPSS software, Version 17.0 for Windows. The crude birth rate over five years remained stable and was within the range of 25,975-26,289 per 1,000 population. The abortion rate constituted 2.018-2.272 per 1,000 population. The abortion ratio was growing until 2016 and composed 26.387 per 1,000 population. The adolescent fertility rate has dropped significantly over the past period from 4,357 per 1,000 teenage population in 2013 to 3,366 per 1,000 teenage population in 2017. The maternal mortality rate did not exceed 0.02 per 1,000 population. Maternal mortality ratio was within the range of 0.208-0.194 per 1,000 population. Incidence rate of extragenital pathology was very high and peaked in 2016 (1,010.800 per 1,000 population). Only 17.4% of women in labor were recognized as healthy based on the labor results. Effective perinatal technologies that were introduced in the Republic of Kazakhstan have demonstrated their high performance in achieving and maintaining a reasonable level of maternity and child health. This was particularly true for stable rate of general fertility and crude birth rate, and decreasing adolescent fertility rate. However, high rates of extragenital pathology indicate the need to implement national preventive programs aimed at ensuring proper monitoring over maternity health indicators.

IL17A gene polymorphisms: relationship to predisposition for chronic viral hepatitis and progression to liver cirrhosis in kazakh population.

Introduction: This work is the first genetic association study of a potential relationship of single nucleotide polymorphisms rs8193036 and rs2275913 located in the IL17A promoter on chromosome 6p12 to chronic viral hepatitis and its progression in Kazakh population. Purpose: Evaluation of the effect of IL17A polymorphism on predisposition for chronic hepatitis B and C and its progression to liver cirrhosis. Materials and Methods: A total of 862 individuals were enrolled in the retrospective case-control association study. Among the participants, 100 patients had chronic hepatitis B and/or C and liver cirrhosis, and 341 patients had chronic viral hepatitis only. Four hundred twenty-one (421) healthy HBV- and HCV-negative donors without liver diseases were recruited as population control. single nucleotide polymorphisms rs8193036[T/C] and rs2275913[G/A] were genotyped by TaqMan assays using genomic DNA extracted from peripheral blood cells. Results. Minor allele frequencies of rs8193036[C] and rs2275913[A] in the groups of patients were very similar to those observed in the control population, 0.4 and 0.3, respectively. Multivariate logistic regression analysis revealed odds ratios close to 1.0 and confidence intervals overlapping with the value of 1.0 and statistical significance p > 0.4 for any groups under comparison in the multiplicative model of inheritance. conclusion: No significant association between two single nucleotide polymorphisms, rs8193036 and rs2275913 in the IL17A promoter, and susceptibility to chronic viral hepatitis C and/or B and disease progression to liver cirrhosis in Kazakh population were found.

Health-related quality of life in Kazakh heart failure patients evaluated by the Minnesota living with heart failure questionnaire and comparison with a published large international sample.

BACKGROUND: To assess health-related quality of life (HRQL) in Kazakh patients (n=285) treated in Cardiology Department of the Emergency Hospital of Semey during 2012 with acute myocardial infarction and to compare results with HRQL measured in 21 countries (n=3,847). METHODS: Telephone interviews survey was conducted in February 2014 with the Russian translation of Minnesota Living with Heart Failure Questionnaire (MLHFQ). Descriptive statistics were used to characterize the sample according to each single item of MLHFQ and grouping them in three subset concerning physical, emotional, and social environment dimensions of patients' life. The distribution of scores was evaluated in terms of floor and ceiling effects; Cronbach's alpha coefficient was calculated for the different dimensions to assess internal consistency. RESULTS: Mean age of sample is 60.8 years, most of patients are male (71.6%) and retired (43.5%). The total MLHFQ score was generally low at a moderate degree (mean 34.7, range 0-105). Physical dimension score (mean 14.92) shows mild to moderate impairment in HRQL and a better perception than the average of the control countries (14.9 vs 16.6); emotional status (mean 4.8) is moderately adequate and better than the controls (4.8 vs 7.2); social environment (9.82) showed significant impairment of HRQL and a worse evaluation (9.82 vs 7.8). CONCLUSIONS: Kazakh patients reported better emotional and physical HRQL as consequence of the social structure where family environment promotes emotional support and improves self-care, social environment affects the total MLHFQ score that is low and related to the requested availability of free medicines.