Ribosome specialization in cancer: a spotlight on ribosomal proteins.

In the past few decades, our view of ribosomes has changed substantially. Rather than passive machines without significant variability, it is now acknowledged that they are heterogeneous, and have direct regulatory capacity. This 'ribosome heterogeneity' comes in many flavors, including in both the RNA and protein components of ribosomes, so there are many paths through which ribosome specialization could arise. It is easy to imagine that specialized ribosomes could have wide physiological roles, through the translation of specific mRNA populations, and there is now evidence for this in several contexts. Translation is highly dysregulated in cancer, needed to support oncogenic phenotypes and to overcome cellular stress. However, the role of ribosome specialization in this is not clear. In this review we focus on specialized ribosomes in cancer. Specifically, we assess the impact that post-translational modifications and differential ribosome incorporation of ribosomal proteins (RPs) have in this disease. We focus on studies that have shown a ribosome-mediated change in translation of specific mRNA populations, and hypothesize how such a process could be driving other phenotypes. We review the impact of RP-mediated heterogeneity in both intrinsic and extrinsic oncogenic processes, and consider how this knowledge could be leveraged to benefit patients.

Latent profiles of emotion regulation among university students: links to repetitive negative thinking, internet addiction, and subjective wellbeing.

Recent years have seen a deterioration in the mental health of university students and notable surge in the need for psychological support. Due to its links to psychopathology and high-risk behaviors, difficulty in emotion regulation frequently serves as a transdiagnostic dimension. This cross-sectional study used a person-centered analytical approach (latent profile analysis; LPA) to identify groups of Portuguese university students with similar profiles of emotion regulation difficulties (N = 261; Mage = 22.5 ± 1.2 years; n = 213 female) and describe how these groups differ in their presentation of repetitive negative thinking, internet addiction, and subjective wellbeing. The analyses identified four latent profiles: 14.5% of students showed global dysregulation (the Low Emotion Regulation Profile), 23% were moderately dysregulated with elevated problems in goal-directed behavior (the Moderate Emotion Regulation Profile), 8% showed specific difficulties with low emotional awareness and clarity (the Low Insight Profile), and 54.4% showed adaptive emotion regulation (the High Emotion Regulation Profile). As anticipated, the Low Emotion Regulation Profile had the lowest subjective wellbeing and the highest prevalence of repetitive negative thinking and internet addiction. Students with a Low Insight Profile also showed low subjective wellbeing, but less repetitive negative thinking compared to the Low Emotion Regulation Profile. Our findings suggest that interventions aimed at improving health and wellbeing among university students should consider each student's unique set of emotion regulation difficulties, rather than focusing on particular strategies. Further research may help determine whether emotion regulation profiles can serve as predictive indicators of varying mental health trajectories and subjective wellbeing in university students.

Diversity, habitat endemicity and trophic ecology of the fauna of Loki's Castle vent field on the Arctic Mid-Ocean Ridge.

Loki's Castle Vent Field (LCVF, 2300 m) was discovered in 2008 and represents the first black-smoker vent field discovered on the Arctic Mid-Ocean Ridge (AMOR). However, a comprehensive faunal inventory of the LCVF has not yet been published, hindering the inclusion of the Arctic in biogeographic analyses of vent fauna. There is an urgent need to understand the diversity, spatial distribution and ecosystem function of the biological communities along the AMOR, which will inform environmental impact assesments of future deep-sea mining activities in the region. Therefore, our aim with this paper is to provide a comprehensive inventory of the fauna at LCVF and present a first insight into the food web of the vent community. The fauna of LCVF has a high degree of novelty, with five new species previously described and another ten new species awaiting formal description. Most of the new species from LCVF are either hydrothermal vent specialists or have been reported from other chemosynthesis-based ecosystems. The highest taxon richness is found in the diffuse venting areas and may be promoted by the biogenic habitat generated by the foundation species Sclerolinum contortum. The isotopic signatures of the vent community of LCVF show a clear influence of chemosynthetic primary production on the foodweb. Considering the novel and specialised fauna documented in this paper, hydrothermal vents on the AMOR should be regarded as vulnerable marine ecosystems and protective measures must therefore be implemented, especially considering the potential threat from resource exploration and exploitation activities in the near future.

Percepções sobre uma intervenção on-line para adolescentes com excesso de peso/obesidade: estudo preliminar / Perceptions on online intervention for overweight/obese adolescents: a preliminary study

Este estudo teve como objetivo analisar as percepções de satisfação dos participantes sobre o APOLO-Teens e fatores comportamentais/psicológicos associados. O APOLO-Teens é um programa psicoeducacional, implementado no Facebook®, durante seis meses, como complemento ao tratamento hospitalar convencional para adolescentes com excesso de peso/obesidade. Participaram 52 adolescentes (71,2% do sexo feminino; M = 14,98 anos, DP = 1,63) que foram alvo do programa APOLO-Teens. Foram avaliados com recurso a medidas de autorrelato quanto à sintomatologia depressiva, qualidade de vida e comportamento alimentar no início, no meio (3 meses) e final da intervenção (6 meses) e preencheram o questionário que avaliou as percepções sobre a participação no programa de intervenção aos 6 meses. Em geral, os participantes revelaram percepções positivas e satisfação com o programa. As sessões de chat tiveram baixa adesão e a maioria dos participantes preferia uma intervenção mais curta. O tema preferido foi "atividade física" e o preterido "alimentação saudável". Verificou-se uma correlação negativa entre satisfação com os resultados e sintomatologia depressiva e comportamento alimentar disfuncional. Como conclusões vale ressaltar alguns aspectos importantes: 1) reconsiderar a duração do programa e tornar as sessões de chat e o tema "alimentação saudável" mais atraentes; 2) priorizar a sintomatologia depressiva e os comportamentos alimentares disfuncionais como forma de otimizar a adesão a estas intervenções.

Satisfaction perception of participants with regard to APOLO-teens and associated behavior and psychological factors are investigated. APOLO-teens is a psycho-educational program implemented by Facebook®, during six months, supplementary to conventional hospital treatment for obese/overweight adolescents. Fifty-two adolescents (71.2% females; M = 14.98 years, DP = 1.63) participated and evaluated by self-reported measures with regard to depression symptoms, life quality and feeding behavior at the start, in the middle (three months) and at the end (six months) of the intervention. A questionnaire was filled with their perceptions on the intervention program after 6 months. As a rule, positive perceptions were given. Chat sessions had low adhesion and post participants preferred a shorter intervention. Preferred theme comprised physical activity, whilst the less appreciated theme was health food. There was a negative co-relationship between satisfaction with results and depression and dysfunctional food behavior. It is important (1) to reconsider duration and make chat and health food more attractive; (2) give priority to depression symptoms and dysfunctional food behavior for better adhesion to intervention.