Bilateral swelling of the salivary glands and sicca symptoms: an unusual differential diagnosis-Kimura's disease, a rare allergic condition with a high IgE serum level-a case report and review of the literature.

A 68-year-old woman presented with bilateral swelling of the salivary glands, sicca symptoms of eyes and mouth, itching, fatigue and weight gain of about 5 kg in the last 2-3 years. As part of a careful diagnostic work up including lab tests for antinuclear antibodies (ANA), antibodies to extractable nuclear antigens (ENA), anti-neutrophilic cytoplasmatic antiobodies (ANCA), immunoglobulin (Ig)G4, a whole body computed tomography (CT) and a parotid biopsy several rheumatic diseases such as Sjoegren's syndrome, IgG4-related disease and sarcoidosis were ruled out and, considering a very high titre of IgE, Kimura's disease was diagnosed. The case and a short review of the literature are presented.

Non-invasive magnetic detection of human injury currents.

OBJECTIVE: Injury currents are a hallmark of acute lesions in polarized cells. Our objective was to develop a non-invasive technique for monitoring human near-DC injury currents in vivo. METHODS: Using diagnostic muscle biopsy as controlled paradigm, injury-related magnetic DC-fields were mapped for 60 min postsurgery over leg muscle lesions of 9 subjects. A 49-channel magnetometer was used in combination with a mechanical horizontal modulation of the subject beneath the sensor array. RESULTS: Magnetic DC-field maps showed salient differences between biopsy and contralateral legs in 8/9 patients with a characteristic slowly decaying field in all biopsy legs. A variety of anomalous DC-field patterns was recorded over the biopsy sites, corresponding to theoretically predicted geometric variations of equivalent DC-current dipoles, i.e. wound surfaces, pointing into opposing muscle fibre ends. By contrast, all control measurements showed an elongated dipolar DC-field pattern. Additionally, mean global DC-field strengths were significantly higher over biopsy legs compared to the contralateral site. CONCLUSIONS: Our pilot data illustrate that human injury currents can be detected using non-invasive magnetometry. Thus, DC-magnetometry may provide an essential new tool for clinical monitoring of injury currents, possibly also in brain tissue, e.g. in case of anoxic or peri-infarct depolarizations.