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1.
Am J Audiol ; 31(1): 45-56, 2022 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-34890217

RESUMO

PURPOSE: The aims of this study were to (a) demonstrate the feasibility of administering categorical loudness scaling (CLS) tests in a remote setting, (b) assess the reliability of remote compared with laboratory CLS results, and (c) provide preliminary evidence of the validity of remote CLS testing. METHOD: CLS data from 21 adult participants collected in a home setting were compared to CLS data collected in a laboratory setting from previous studies. Five participants took part in studies in both settings. Precalibrated equipment was delivered to participants who performed headphone output level checks and measured ambient noise levels. After a practice run, CLS measurements were collected for two runs at 1 and 4 kHz. RESULTS: Mean headphone output levels were within 1.5 dB of the target calibration level. Mean ambient noise levels were below the target level. Within-run variability was similar between the two settings, but across-run bias was smaller for data collected in the laboratory setting compared with the remote setting. Systematic differences in CLS functions were not observed for the five individuals who participated in both settings. CONCLUSIONS: This study demonstrated that precise stimulus levels can be delivered and background noise levels can be controlled in a home environment. Across-run bias for remote CLS was larger than for in-laboratory CLS, indicating that further work is needed to improve the reliability of CLS data collected in remote settings. Supplemental Material https://doi.org/10.23641/asha.17131856.


Assuntos
Percepção Sonora , Adulto , Limiar Auditivo , Humanos , Reprodutibilidade dos Testes
2.
Ear Hear ; 43(3): 773-784, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34759207

RESUMO

OBJECTIVES: Despite a diagnosis of normal hearing, many people experience hearing disability (HD) in their everyday lives. This study assessed the ability of a number of demographic and auditory variables to explain and predict self-reported HD in people regarded as audiologically healthy via audiometric thresholds. DESIGN: One-hundred eleven adults (ages 19 to 74) with clinically normal hearing (i.e., audiometric thresholds ≤25 dB HL at all octave and interoctave frequencies between 0.25 and 8 kHz and bilaterally symmetric hearing) were asked to complete the 12-item version of the Speech, Spatial, and Qualities of Hearing Scale (SSQ12) as a measure of self-reported HD. Patient history and a number of standard and expanded measures of hearing were assessed in a multivariate regression analysis to predict SSQ12 score. Patient history included age, sex, history of noise exposure, and tinnitus. Hearing-related measures included audiometry at standard and extended high frequencies, word recognition, otoacoustic emissions, auditory brainstem response, the Montreal Cognitive Assessment, and FM detection threshold. RESULTS: History of impulse noise exposure, speech-intelligibility index, and FM detection threshold accurately predicted SSQ12 and were able to account for 40% of the SSQ12 score. These three measures were also able to predict whether participants self-reported HD with a sensitivity of 89% and specificity of 86%. CONCLUSIONS: Although participant audiometric thresholds were within normal limits, higher thresholds, history of impulse noise exposure, and FM detection predicted self-reported HD.


Assuntos
Audição , Emissões Otoacústicas Espontâneas , Adulto , Idoso , Audiometria , Audiometria de Tons Puros , Limiar Auditivo/fisiologia , Audição/fisiologia , Humanos , Pessoa de Meia-Idade , Autorrelato , Adulto Jovem
3.
Front Psychol ; 11: 578352, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33281677

RESUMO

Categorical loudness scaling (CLS) measures provide useful information about an individual's loudness perception across the dynamic range of hearing. A probability model of CLS categories has previously been described as a multi-category psychometric function (MCPF). In the study, a representative "catalog" of potential listener MCPFs was used in conjunction with maximum-likelihood estimation to derive CLS functions for participants with normal hearing and with hearing loss. The approach of estimating MCPFs for each listener has the potential to improve the accuracy of the CLS measurements, particularly when a relatively low number of data points are available. The present study extends the MCPF approach by using Bayesian inference to select stimulus parameters that are predicted to yield maximum expected information (MEI) during data collection. The accuracy and reliability of the MCPF-MEI approach were compared to the standardized CLS measurement procedure (ISO 16832:2006, 2006). A non-adaptive, fixed-level, paradigm served as a "gold-standard" for this comparison. The test time required to obtain measurements in the standard procedure is a major barrier to its clinical uptake. Test time was reduced from approximately 15 min to approximately 3 min with the MEI-adaptive procedure. Results indicated that the test-retest reliability and accuracy of the MCPF-MEI adaptive procedures were similar to the standardized CLS procedure. Computer simulations suggest that the reliability and accuracy of the MEI procedure were limited by intrinsic uncertainty of the listeners represented in the MCPF catalog. In other words, the MCPF provided insufficient predictive power to significantly improve adaptive-tracking efficiency under practical conditions. Concurrent optimization of both the MCPF catalog and the MEI-adaptive procedure have the potential to produce better results. Regardless of the adaptive-tracking method used in the CLS procedure, the MCPF catalog remains clinically useful for enabling maximum-likelihood determination of loudness categories.

4.
J Acoust Soc Am ; 147(1): 25, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-32006985

RESUMO

Use of the auditory brainstem response (ABR) in research has increased in the search for physiological correlates of noise-induced damage to the cochlea. The extraction of data from the ABR has traditionally relied on visual determination of peaks and troughs to calculate metrics such as wave amplitude. Visual determination can be reliable when evaluated by trained, experienced personnel, but noisy waveforms and overlapping waves produce uncertain data. The present study proposes and validates a method of fitting summed Gaussian functions to the summating potential and wave I of the ABR. This method could be useful to the research community studying these potentials by providing more accurate measures of wave amplitude than by visual determination.


Assuntos
Potenciais Evocados Auditivos do Tronco Encefálico , Audição/fisiologia , Processamento de Sinais Assistido por Computador , Estimulação Acústica , Adulto , Audiometria , Interpretação Estatística de Dados , Feminino , Perda Auditiva Neurossensorial/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Neurológicos , Distribuição Normal
5.
Ear Hear ; 41(2): 451-460, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31369471

RESUMO

OBJECTIVES: Cochlear reflectance (CR) is the cochlear contribution to ear-canal reflectance. CR is a type of otoacoustic emission that is calculated as a transfer function between forward pressure and reflected pressure. The purpose of this study was to assess effects of age on CR in adults and interactions among age, sex, and hearing loss. DESIGN: Data were collected from 60 adults selected for their age (e.g., 20-29, 30-39, 40-49, 50-59, 60-69, 70-79 years) and normal middle ear status. A wideband noise stimulus presented at three stimulus levels (30, 40, 50 dB SPL) was used to elicit CR. Half-octave bands of CR signal magnitude (CRM), CR noise, and the CR signal-to-noise ratio (CR-SNR) were extracted from the wideband CR response. Regression analyses were conducted to assess interactions among CR, age, sex, and pure-tone thresholds at closely matched frequency bands across stimulus levels. RESULTS: Although increased age was generally associated with lower CRM and CR-SNR at some band frequencies and stimulus levels, no significant effects of age remained after controlling for effects of pure-tone thresholds. Increases in pure-tone thresholds were associated with lower CRM and CR-SNR at most frequency bands and stimulus levels. Effects of hearing sensitivity were significant at some frequencies and levels after controlling for age and sex. CONCLUSIONS: When effects of age were controlled, adults with better hearing had significantly larger CRM and CR-SNR than those with poorer hearing. In contrast, when effects of hearing were controlled, no significant effects of age on CRM and CR-SNR remained.


Assuntos
Perda Auditiva , Emissões Otoacústicas Espontâneas , Adulto , Audiometria de Tons Puros , Limiar Auditivo , Cóclea , Audição , Testes Auditivos , Humanos , Adulto Jovem
6.
J Acoust Soc Am ; 146(5): 3947, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31795718

RESUMO

The consequences of noise exposure on the auditory system are not entirely understood. In animals, noise exposure causes selective synaptopathy-an uncoupling of auditory nerve fibers from sensory cells-mostly in fibers that respond to high sound levels. Synaptopathy can be measured physiologically in animals, but a direct relationship between noise exposure and synaptopathy in humans has yet to be proven. Sources of variability, such as age, indirect measures of noise exposure, and comorbid auditory disorders, obfuscate attempts to find concrete relationships between noise exposure, synaptopathy, and perceptual consequences. This study adds to the ongoing effort by examining relationships between noise exposure, auditory brainstem response (ABR) amplitudes, and speech perception in adults of various ages and audiometric thresholds and a subset of younger adults with clinically normal hearing. Regression models including noise exposure, age, hearing thresholds, and sex as covariates were compared to find a best-fitting model of toneburst ABR wave I amplitude at two frequencies and word recognition performance in three listening conditions: background noise, time compression, and time compression with reverberation. The data suggest the possibility of detecting synaptopathy in younger adults using physiological measures, but that age and comorbid hearing disorders may hinder attempts to assess noise-induced synaptopathy.


Assuntos
Percepção Auditiva , Potenciais Evocados Auditivos do Tronco Encefálico , Perda Auditiva Provocada por Ruído/fisiopatologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Feminino , Perda Auditiva Provocada por Ruído/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Ruído/efeitos adversos , Fatores Sexuais
7.
Am J Audiol ; 28(4): 843-856, 2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31647880

RESUMO

Purpose The aim of this study was to quantify the portion of variance in several measures suggested to be indicative of peripheral noise-induced cochlear synaptopathy and hidden hearing disorder that can be attributed to individual cognitive capacity. Method Regression and relative importance analysis was used to model several behavioral and physiological measures of hearing in 32 adults ranging in age from 20 to 74 years. Predictors for the model were hearing sensitivity and performance on a number of cognitive tasks. Results There was a significant influence of cognitive capacity on several measures of cochlear synaptopathy and hidden hearing disorder. These measures include frequency modulation detection threshold, time-compressed word recognition in quiet and reverberation, and the strength of the frequency-following response of the speech-evoked auditory brainstem response. Conclusions Measures of hearing that involve temporal processing are significantly influenced by cognitive abilities, specifically, short-term and working memory capacity, executive function, and attention. Research using measures of temporal processing to diagnose peripheral disorders, such as noise-induced synaptopathy, need to consider cognitive influence even in a young, healthy population.


Assuntos
Cóclea/lesões , Cognição/fisiologia , Perda Auditiva Provocada por Ruído/fisiopatologia , Perda Auditiva/fisiopatologia , Testes de Impedância Acústica , Adulto , Idoso , Audiometria , Limiar Auditivo , Cóclea/fisiopatologia , Feminino , Perda Auditiva/psicologia , Perda Auditiva Provocada por Ruído/psicologia , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Neurossensorial/psicologia , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Percepção da Fala , Adulto Jovem
8.
Ear Hear ; 40(6): 1267-1279, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30882533

RESUMO

OBJECTIVES: Recent animal studies have shown that noise exposure can cause cochlear synaptopathy without permanent threshold shift. Because the noise exposure preferentially damaged auditory nerve fibers that processed suprathreshold sounds (low-spontaneous rate fibers), it has been suggested that synaptopathy may underlie suprathreshold hearing deficits in humans. Recently, several researchers have suggested measures to identify the pathology or pathologies underlying suprathreshold hearing deficits in humans based on results from animal studies; however, the reliability of some of these measures have not been assessed. The purpose of this study was to assess the test-retest reliability of measures that may have the potential to relate suprathreshold hearing deficits to site(s)-of-lesion along the peripheral auditory system in humans. DESIGN: Adults with audiometric normal hearing were tested on a battery of behavioral and physiologic measures that included (1) thresholds in quiet (TIQ), (2) thresholds in noise (TIN), (3) frequency-modulation detection threshold (FMDT), (4) word recognition in four listening conditions, (5) distortion-product otoacoustic emissions (DPOAE), (6) middle ear muscle reflex (MEMR), (7) tone burst-elicited auditory brainstem response (tbABR), and (8) speech-evoked ABR (sABR). Data collection for each measure was repeated over two visits separated by at least one week. The residuals of the correlation between the suprathreshold measures and TIQ serve as functional and quantitative proxies for threshold-independent hearing disorders because they represent the portion of the raw measures that is not dependent on TIQ. Reliability of the residual measures was assessed using intraclass correlation (ICC). RESULTS: Reliability for the residual measures was good (ICC ≥ 0.75) for FMDT, DPOAEs, and MEMR. Residual measures showing moderate reliability (0.5 ≤ ICC < 0.75) were tbABR wave I amplitude, TIN, and word recognition in quiet, noise, and time-compressed speech with reverberation. Wave V of the tbABR, waves of the sABR, and recognition of time-compressed words had poor test-retest reliability (ICC < 0.5). CONCLUSIONS: Reliability of residual measures was mixed, suggesting that care should be taken when selecting measures for diagnostic tests of threshold-independent hearing disorders. Quantifying hidden hearing loss as the variance in suprathreshold measures of auditory function that is not due to TIQ may provide a reliable estimate of threshold-independent hearing disorders in humans.


Assuntos
Perda Auditiva/diagnóstico , Testes Auditivos , Adulto , Audiometria de Tons Puros , Limiar Auditivo , Potenciais Evocados Auditivos do Tronco Encefálico , Feminino , Perda Auditiva/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Ruído , Emissões Otoacústicas Espontâneas , Reprodutibilidade dos Testes , Teste do Limiar de Recepção da Fala , Adulto Jovem
9.
J Am Acad Audiol ; 30(1): 16-30, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30461387

RESUMO

BACKGROUND: In listening environments with background noise that fluctuates in level, listeners with normal hearing can "glimpse" speech during dips in the noise, resulting in better speech recognition in fluctuating noise than in steady noise at the same overall level (referred to as masking release). Listeners with sensorineural hearing loss show less masking release. Amplification can improve masking release but not to the same extent that it does for listeners with normal hearing. PURPOSE: The purpose of this study was to compare masking release for listeners with sensorineural hearing loss obtained with an experimental hearing-aid signal-processing algorithm with instantaneous compression (referred to as a suppression hearing aid, SHA) to masking release obtained with fast compression. The suppression hearing aid mimics effects of normal cochlear suppression, i.e., the reduction in the response to one sound by the simultaneous presentation of another sound. RESEARCH DESIGN: A within-participant design with repeated measures across test conditions was used. STUDY SAMPLE: Participants included 29 adults with mild-to-moderate sensorineural hearing loss and 21 adults with normal hearing. INTERVENTION: Participants with sensorineural hearing loss were fitted with simulators for SHA and a generic hearing aid (GHA) with fast (but not instantaneous) compression (5 ms attack and 50 ms release times) and no suppression. Gain was prescribed using either an experimental method based on categorical loudness scaling (CLS) or the Desired Sensation Level (DSL) algorithm version 5a, resulting in a total of four processing conditions: CLS-GHA, CLS-SHA, DSL-GHA, and DSL-SHA. DATA COLLECTION: All participants listened to consonant-vowel-consonant nonwords in the presence of temporally-modulated and steady noise. An adaptive-tracking procedure was used to determine the signal-to-noise ratio required to obtain 29% and 71% correct. Measurements were made with amplification for participants with sensorineural hearing loss and without amplification for participants with normal hearing. ANALYSIS: Repeated-measures analysis of variance was used to determine the influence of within-participant factors of noise type and, for participants with sensorineural hearing loss, processing condition on masking release. Pearson correlational analysis was used to assess the effect of age on masking release for participants with sensorineural hearing loss. RESULTS: Statistically significant masking release was observed for listeners with sensorineural hearing loss for 29% correct, but not for 71% correct. However, the amount of masking release was less than masking release for participants with normal hearing. There were no significant differences among the amplification conditions for participants with sensorineural hearing loss. CONCLUSIONS: The results suggest that amplification with either instantaneous or fast compression resulted in similar masking release for listeners with sensorineural hearing loss. However, the masking release was less for participants with hearing loss than it was for those with normal hearing.


Assuntos
Perda Auditiva Neurossensorial/diagnóstico , Ruído , Mascaramento Perceptivo , Teste do Limiar de Recepção da Fala/métodos , Adulto , Idoso , Algoritmos , Limiar Auditivo , Feminino , Auxiliares de Audição , Humanos , Percepção Sonora , Masculino , Pessoa de Meia-Idade
10.
Ear Hear ; 40(4): 951-960, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30399010

RESUMO

OBJECTIVES: Cochlear reflectance (CR) is the cochlear contribution to ear-canal reflectance. CR is a type of otoacoustic emission (OAE) that is calculated as a transfer function between forward pressure and reflected pressure. The purpose of this study was to compare wideband CR to distortion-product (DP) OAEs in two ways: (1) in a clinical-screening paradigm where the task is to determine whether an ear is normal or has hearing loss and (2) in the prediction of audiometric thresholds. The goal of the study was to assess the clinical utility of CR. DESIGN: Data were collected from 32 normal-hearing and 124 hearing-impaired participants. A wideband noise stimulus presented at 3 stimulus levels (30, 40, 50 dB sound pressure level) was used to elicit the CR. DPOAEs were elicited using primary tones spanning a wide frequency range (1 to 16 kHz). Predictions of auditory status (i.e., hearing-threshold category) and predictions of audiometric threshold were based on regression analysis. Test performance (identification of normal versus impaired hearing) was evaluated using clinical decision theory. RESULTS: When regressions were based only on physiological measurements near the audiometric frequency, the accuracy of CR predictions of auditory status and audiometric threshold was less than reported in previous studies using DPOAE measurements. CR predictions were improved when regressions were based on measurements obtained at many frequencies. CR predictions were further improved when regressions were performed on males and females separately. CONCLUSIONS: Compared with CR measurements, DPOAE measurements have the advantages in a screening paradigm of better test performance and shorter test time. The full potential of CR measurements to predict audiometric thresholds may require further improvements in signal-processing methods to increase its signal to noise ratio. CR measurements have theoretical significance in revealing the number of cycles of delay at each frequency that is most sensitive to hearing loss.


Assuntos
Perda Auditiva Neurossensorial/diagnóstico , Emissões Otoacústicas Espontâneas/fisiologia , Testes de Impedância Acústica , Adulto , Idoso , Meato Acústico Externo , Feminino , Perda Auditiva Neurossensorial/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Análise de Regressão , Sensibilidade e Especificidade , Adulto Jovem
11.
J Acoust Soc Am ; 146(6): 4481, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31893726

RESUMO

Distortion-product otoacoustic emission (DPOAE) and stimulus-frequency otoacoustic emission (SFOAE) are two types of acoustic signals emitted by the inner ear in response to tonal stimuli. The levels of both emission types may be reduced by the inclusion of additional (suppressor) tones with the stimulus. Comparison of two-tone suppression properties across emission type addresses a clinically relevant question of whether these two types of emission provide similar information about cochlear status. The purpose of this study was to compare DPOAE suppression to SFOAE suppression from the same ear in a group of participants with normal hearing. Probe frequency was approximately 1000 Hz, and the suppressor frequency varied from -1.5 to 0.5 octaves relative to the probe frequency. DPOAE and SFOAE suppression were compared in terms of (1) suppression growth rate (SGR), (2) superimposed suppression tuning curves (STCs), and (3) STC-derived metrics, such as high-frequency slope, cochlear amplifier gain, and QERB (ERB, equivalent rectangular bandwidth). Below the probe frequency, the SGR was slightly greater than one for SFOAEs and slightly less than two for DPOAEs. There were no differences in STC metrics across emission types. These observations may provide useful constraints on physiology-based models of otoacoustic emission suppression.


Assuntos
Estimulação Acústica , Cóclea/fisiologia , Emissões Otoacústicas Espontâneas/fisiologia , Estimulação Acústica/métodos , Acústica , Adulto , Feminino , Humanos , Masculino , Modelos Biológicos
12.
J Acoust Soc Am ; 143(5): 2994, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29857738

RESUMO

Loudness depends on both the intensity and spectrum of a sound. Listeners with normal hearing perceive a broadband sound as being louder than an equal-level narrowband sound because loudness grows nonlinearly with level and is then summed across frequency bands. This difference in loudness as a function of bandwidth is reduced in listeners with sensorineural hearing loss (SNHL). Suppression, the reduction in the cochlear response to one sound by the simultaneous presentation of another sound, is also reduced in listeners with SNHL. Hearing-aid gain that is based on loudness measurements with pure tones may fail to restore normal loudness growth for broadband sounds. This study investigated whether hearing-aid amplification that mimics suppression can improve loudness summation for listeners with SNHL. Estimates of loudness summation were obtained using measurements of categorical loudness scaling (CLS). Stimuli were bandpass-filtered noises centered at 2 kHz with bandwidths in the range of 0.1-6.4 kHz. Gain was selected to restore normal loudness based on CLS measurements with pure tones. Gain that accounts for both compression and suppression resulted in better restoration of loudness summation, compared to compression alone. However, restoration was imperfect, suggesting that additional refinements to the signal processing and gain-prescription algorithms are needed.


Assuntos
Estimulação Acústica/métodos , Auxiliares de Audição , Perda Auditiva/fisiopatologia , Perda Auditiva/terapia , Percepção Sonora/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Percepção Auditiva/fisiologia , Feminino , Perda Auditiva/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
13.
J Acoust Soc Am ; 143(3): 1491, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29604709

RESUMO

The calibration of an ear probe to determine its Thévenin-equivalent acoustic source parameters facilitates the measurement of ear-canal impedance and reflectance. Existing calibration error metrics, used to evaluate the quality of a calibration, are unable to reveal undesired parallel components in the source parameters. Such parallel components can result from, e.g., a leak in the ear tip or improperly accounting for evanescent modes, and introduce errors into subsequent measurements of impedance and reflectance. This paper proposes a set of additional error metrics that are capable of detecting such parallel components by examining the causality of the source admittance in the frequency domain and estimating the source pressure in the time domain. The proposed and existing error metrics are applied to four different calibrations using two existing calibration methods, representing typical use cases and introducing deliberate parallel components. The results demonstrate the capability of the proposed error metrics in identifying various undesired components in the source parameters that might otherwise go undetected.


Assuntos
Testes de Impedância Acústica , Calibragem , Testes de Impedância Acústica/instrumentação , Testes de Impedância Acústica/normas , Meato Acústico Externo , Humanos , Teste de Materiais/métodos , Modelos Teóricos
14.
Ear Hear ; 39(5): 829-844, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29337760

RESUMO

OBJECTIVES: Recent animal studies suggest that noise-induced synaptopathy may underlie a phenomenon that has been labeled hidden hearing loss (HHL). Noise exposure preferentially damages low spontaneous-rate auditory nerve fibers, which are involved in the processing of moderate- to high-level sounds and are more resistant to masking by background noise. Therefore, the effect of synaptopathy may be more evident in suprathreshold measures of auditory function, especially in the presence of background noise. The purpose of this study was to develop a statistical model for estimating HHL in humans using thresholds in noise as the outcome variable and measures that reflect the integrity of sites along the auditory pathway as explanatory variables. Our working hypothesis is that HHL is evident in the portion of the variance observed in thresholds in noise that is not dependent on thresholds in quiet, because this residual variance retains statistical dependence on other measures of suprathreshold function. DESIGN: Study participants included 13 adults with normal hearing (≤15 dB HL) and 20 adults with normal hearing at 1 kHz and sensorineural hearing loss at 4 kHz (>15 dB HL). Thresholds in noise were measured, and the residual of the correlation between thresholds in noise and thresholds in quiet, which we refer to as thresholds-in-noise residual, was used as the outcome measure for the model. Explanatory measures were as follows: (1) auditory brainstem response (ABR) waves I and V amplitudes; (2) electrocochleographic action potential and summating potential amplitudes; (3) distortion product otoacoustic emissions level; and (4) categorical loudness scaling. All measurements were made at two frequencies (1 and 4 kHz). ABR and electrocochleographic measurements were made at 80 and 100 dB peak equivalent sound pressure level, while wider ranges of levels were tested during distortion product otoacoustic emission and categorical loudness scaling measurements. A model relating the thresholds-in-noise residual and the explanatory measures was created using multiple linear regression analysis. RESULTS: Predictions of thresholds-in-noise residual using the model accounted for 61% (p < 0.01) and 48% (p < 0.01) of the variance in the measured thresholds-in-noise residual at 1 and 4 kHz, respectively. CONCLUSIONS: Measures of thresholds in noise, the summating potential to action potential ratio, and ABR waves I and V amplitudes may be useful for the prediction of HHL in humans. With further development, our approach of quantifying HHL by the variance that remains in suprathreshold measures of auditory function after removing the variance due to thresholds in quiet, together with our statistical modeling, may provide a quantifiable and verifiable estimate of HHL in humans with normal hearing and with hearing loss. The current results are consistent with the view that inner hair cell and auditory nerve pathology may underlie suprathreshold auditory performance.


Assuntos
Limiar Auditivo , Potenciais Evocados Auditivos do Tronco Encefálico , Perda Auditiva Provocada por Ruído/diagnóstico , Audição/fisiologia , Adulto , Estudos de Casos e Controles , Nervo Coclear/fisiopatologia , Feminino , Perda Auditiva Provocada por Ruído/fisiopatologia , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/fisiopatologia , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Ruído
15.
J Acoust Soc Am ; 142(4): 2155, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-29092611

RESUMO

The level-dependent component of the latency of human auditory brainstem responses (ABR) to tonebursts decreases by about 38% for every 20-dB increase in stimulus level over a wide range of both frequency and level [Neely, Norton, Gorga, and Jesteadt (1998). J. Acoust. Soc. Am. 31, 87-97]. This level-dependence has now been simulated in an active, nonlinear, transmission-line model of cochlear mechanics combined with an adaptation stage. The micromechanics in this model are similar to previous models except that a dual role is proposed for the tectorial membrane (TM): (1) passive sharpening the tuning of sensory-cell inputs (relative to basilar-membrane vibrations) and (2) providing an optimal phase shift (relative to basilar-membrane vibrations) of outer-hair-cell feedback forces, so that amplification is restricted to a limited range of frequencies. The adaptation stage, which represents synaptic adaptation of neural signals, contributes to the latency level-dependence more at low frequencies than at high frequencies. Compression in this model spans the range of audible sound levels with a compression ratio of about 2:1. With further development, the proposed model of cochlear micromechanics could be useful both (1) as a front-end to functional models of the auditory system and (2) as a foundation for understanding the physiological basis of cochlear amplification.


Assuntos
Cóclea/inervação , Nervo Coclear/fisiologia , Audição , Mecanotransdução Celular , Modelos Neurológicos , Som , Estimulação Acústica , Vias Auditivas/fisiologia , Tronco Encefálico/fisiologia , Potenciais Evocados Auditivos do Tronco Encefálico , Células Ciliadas Auditivas Externas/fisiologia , Humanos , Movimento (Física) , Dinâmica não Linear , Tempo de Reação , Membrana Tectorial/inervação , Fatores de Tempo , Vibração
16.
J Acoust Soc Am ; 142(6): 3660, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-29289103

RESUMO

The goal of this study was to reconcile the differences between measures of loudness obtained with continuous, unbounded scaling procedures, such as magnitude estimation and production, and those obtained using a limited number of discrete categories, such as categorical loudness scaling (CLS). The former procedures yield data with ratio properties, but some listeners find it difficult to generate numbers proportional to loudness and the numbers cannot be compared across listeners to explore individual differences. CLS, where listeners rate loudness on a verbal scale, is an easier task, but the numerical values or categorical units (CUs) assigned to the points on the scale are not proportional to loudness. Sufficient CLS data are now available to assign values in sones, a scale proportional to loudness, to the loudness categories. As a demonstration of this approach, data from Heeren, Hohmann, Appell, and Verhey [J. Acoust. Soc. Am. 133, EL314-EL319 (2013)] were used to develop a CUsone metric, whose values were then substituted for the original CU values in reanalysis of a large set of CLS data obtained by Rasetshwane, Trevino, Gombert, Liebig-Trehearn, Kopun, Jesteadt, Neely, and Gorga [J. Acoust. Soc. Am. 137, 1899-1913 (2015)]. The resulting data are well fitted by power functions and are in general agreement with previously published results obtained with magnitude estimation, magnitude production, and cross modality matching.


Assuntos
Perda Auditiva Neurossensorial/psicologia , Julgamento , Percepção Sonora , Estimulação Acústica , Adolescente , Adulto , Audiometria de Tons Puros , Limiar Auditivo , Criança , Feminino , Audição , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Adulto Jovem
17.
J Acoust Soc Am ; 139(5): 2299, 2016 05.
Artigo em Inglês | MEDLINE | ID: mdl-27250125

RESUMO

The purpose of this study was to investigate the combined effect of multiple suppressors. Distortion-product otoacoustic emission (DPOAE) measurements were made in normal-hearing participants. Primary tones had fixed frequencies (f2 = 4000 Hz; f1 / f2 = 1.22) and a range of levels. Suppressor tones were at three frequencies (fs = 2828, 4100, 4300 Hz) and range of levels. Decrement was defined as the attenuation in DPOAE level due to the presence of a suppressor. A measure of suppression called suppressive intensity was calculated by an equation previously shown to fit DPOAE suppression data. Suppressor pairs, which were the combination of two different frequencies, were presented at levels selected to have equal single-suppressor decrements. A hybrid model that represents a continuum between additive intensity and additive attenuation best described the results. The suppressor pair with the smallest frequency ratio produced decrements that were more consistent with additive intensity. The suppressor pair with the largest frequency ratio produced decrements at the highest level that were consistent with additive attenuation. Other suppressor-pair conditions produced decrements that were intermediate between these two alternative models. The hybrid model provides a useful framework for representing the observed range of interaction when two suppressors are combined.


Assuntos
Percepção Auditiva , Ruído/efeitos adversos , Emissões Otoacústicas Espontâneas , Mascaramento Perceptivo , Estimulação Acústica , Adulto , Audiometria , Humanos , Pessoa de Meia-Idade , Adulto Jovem
18.
J Acoust Soc Am ; 138(4): 2246-55, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26520306

RESUMO

Variability in wideband acoustic reflectance (and absorbance) measurements adversely affects the clinical utility of reflectance for diagnosis of middle-ear disorders. A reflectance standard would encourage consistency across different measurement systems and help identify calibration related issues. Theoretical equations exist for the reflectance of finite-length exponential, conical, and parabolic acoustic horns. Reflectance measurements were repeatedly made in each of these three horn shapes and the results were compared to the corresponding theoretical reflectance. A method is described of adjusting acoustic impedance measurements to compensate for spreading of the wave front that propagates from the small diameter sound port of the probe to the larger diameter of the acoustic cavity. Agreement between measured and theoretical reflectance was less than 1 dB at most frequencies in the range from 0.2 to 10 kHz. Pearson correlation coefficients were greater than 0.95 between measured and theoretical time-domain reflectance within the flare region of the horns. The agreement suggests that the distributed reflectance of acoustic horns may be useful for validating reflectance measurements made in human ear canals; however, refinements to reflectance measurement methods may still be needed.


Assuntos
Acústica/instrumentação , Testes de Impedância Acústica/métodos , Desenho de Equipamento , Impressão Tridimensional , Padrões de Referência
19.
J Acoust Soc Am ; 137(4): 1899-913, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25920842

RESUMO

This study describes procedures for constructing equal-loudness contours (ELCs) in units of phons from categorical loudness scaling (CLS) data and characterizes the impact of hearing loss on these estimates of loudness. Additionally, this study developed a metric, level-dependent loudness loss, which uses CLS data to specify the deviation from normal loudness perception at various loudness levels and as function of frequency for an individual listener with hearing loss. CLS measurements were made in 87 participants with hearing loss and 61 participants with normal hearing. An assessment of the reliability of CLS measurements was conducted on a subset of the data. CLS measurements were reliable. There was a systematic increase in the slope of the low-level segment of the CLS functions with increase in the degree of hearing loss. ELCs derived from CLS measurements were similar to standardized ELCs (International Organization for Standardization, ISO 226:2003). The presence of hearing loss decreased the vertical spacing of the ELCs, reflecting loudness recruitment and reduced cochlear compression. Representing CLS data in phons may lead to wider acceptance of CLS measurements. Like the audiogram that specifies hearing loss at threshold, level-dependent loudness loss describes deficit for suprathreshold sounds. Such information may have implications for the fitting of hearing aids.


Assuntos
Perda Auditiva/fisiopatologia , Audição/fisiologia , Percepção Sonora/fisiologia , Adolescente , Adulto , Idoso , Limiar Auditivo/fisiologia , Orelha Média/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fônons , Reprodutibilidade dos Testes , Adulto Jovem
20.
Ear Hear ; 36(1): 155-63, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25170779

RESUMO

OBJECTIVE: Accurate ear-canal acoustic measurements, such as wideband acoustic admittance, absorbance, and otoacoustic emissions, require that the measurement probe be tightly sealed in the ear canal. Air leaks can compromise the validity of the measurements, interfere with calibrations, and increase variability. There are no established procedures for determining the presence of air leaks or criteria for what size leak would affect the accuracy of ear-canal acoustic measurements. The purpose of this study was to determine ways to quantify the effects of air leaks and to develop objective criteria to detect their presence. DESIGN: Air leaks were simulated by modifying the foam tips that are used with the measurement probe through insertion of thin plastic tubing. To analyze the effect of air leaks, acoustic measurements were taken with both modified and unmodified foam tips in brass-tube cavities and human ear canals. Measurements were initially made in cavities to determine the range of critical leaks. Subsequently, data were collected in ears of 21 adults with normal hearing and normal middle-ear function. Four acoustic metrics were used for predicting the presence of air leaks and for quantifying these leaks: (1) low-frequency admittance phase (averaged over 0.1-0.2 kHz), (2) low-frequency absorbance, (3) the ratio of compliance volume to physical volume (CV/PV), and (4) the air-leak resonance frequency. The outcome variable in this analysis was the absorbance change (Δabsorbance), which was calculated in eight frequency bands. RESULTS: The trends were similar for both the brass cavities and the ear canals. ΔAbsorbance generally increased with air-leak size and was largest for the lower frequency bands (0.1-0.2 and 0.2-0.5 kHz). Air-leak effects were observed in frequencies up to 10 kHz, but their effects above 1 kHz were unpredictable. These high-frequency air leaks were larger in brass cavities than in ear canals. Each of the four predictor variables exhibited consistent dependence on air-leak size. Low-frequency admittance phase and CV/PV decreased, while low-frequency absorbance and the air-leak resonance frequency increased. CONCLUSION: The effect of air leaks can be significant when their equivalent diameter exceeds 0.01 in. The observed effects were greatest at low frequencies where air leaks caused absorbance to increase. Recommended criteria for detecting air leaks include the following: when the frequency range of interest extends as low as 0.1 kHz, low-frequency absorbance should be ≤0.20 and low-frequency admittance phase ≥61 degrees. For frequency ranges as low as 0.2 kHz, low-frequency absorbance should be ≤0.29 and low-frequency admittance phase ≥44 degrees.


Assuntos
Acústica , Meato Acústico Externo/fisiologia , Testes Auditivos/métodos , Emissões Otoacústicas Espontâneas/fisiologia , Adulto , Calibragem , Testes Auditivos/instrumentação , Humanos , Adulto Jovem
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