RESUMO
In screening for antifungal metabolites a novel compound, cladobotryal, was isolated from the mycoparasitic fungus Cladobotryum varium. Its structure was established as (+)-(2R*,3R*)-2-[(Z)-2-buten-2-yl]-3, 7-dihydro-3-formyl-3-methyl-5-phenylfuro[2,3-b]pyridin-4(2H)-one on the basis of spectroscopic evidence and single crystal X-ray analysis of its methyl hemiacetal. The fused furo[2,3-b]pyridinone skeleton of cladobotryal seems unprecedented within the chemical literature.
Assuntos
Antifúngicos/química , Fungos/química , Furanos/química , Piridonas/química , Antifúngicos/isolamento & purificação , Furanos/isolamento & purificação , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Estrutura Molecular , Piridonas/isolamento & purificação , Difração de Raios XRESUMO
The new species Penicillium discolor, frequently isolated from nuts, vegetables and cheese is described. It is characterised by rough, dark green conidia, synnemateous growth on malt agar and the production of the secondary metabolites chaetoglobosins A, B and C, palitantin, cyclopenin, cyclopenol, cyclopeptin, dehydrocyclopeptin, viridicatin and viridicatol. It also produces the mouldy smelling compounds geosmin and 2-methyl-isoborneol, and a series of specific orange to red pigments on yeast extract sucrose agar, hence the epithet discolor. P. discolor resembles P. echinulatum morphologically but on basis of the secondary metabolites is also related to P. expansum, P. solitum and P. crustosum.
Assuntos
Queijo/microbiologia , Nozes/microbiologia , Penicillium/isolamento & purificação , Verduras/microbiologia , Benzodiazepinonas/metabolismo , Canfanos/metabolismo , Meios de Cultura/metabolismo , Cicloexanóis/metabolismo , Cicloexanonas/metabolismo , Microbiologia de Alimentos , Hidroxiquinolinas/metabolismo , Alcaloides Indólicos , Indóis/metabolismo , Microscopia Eletrônica de Varredura , Naftóis/metabolismo , Penicillium/crescimento & desenvolvimento , Penicillium/metabolismo , Pigmentos Biológicos/metabolismo , Quinolonas/metabolismo , Sacarose/metabolismoRESUMO
Oxysporidinone (1), a novel 3,5-disubstituted N-methyl-4-hydroxy-2-pyridone, was isolated from fermentations of Fusarium oxysporum (CBS 330.95) by counter-current chromatography. The structure was determined by spectroscopic methods including NMR, MS, IR, and UV analysis. Oxysporidinone exhibited growth inhibitory activity against several common plant pathogenic fungi.