RESUMO
Injection of viscous or semisolid materials into the penile shaft to increase its size, to correct erectile dysfunction, and/or to satisfy a sexual partner has only been sporadically reported in Eastern and Western European and American men. However, this practice appears to be more widespread in the countries of Southeast Asia. We present 3 cases of Hmong patients seen in a urology clinic in Wausau, Wis. We describe the presentation, correction, and difficulties experienced in convincing patients to undergo adequate treatment.
Assuntos
Granuloma de Corpo Estranho/cirurgia , Injeções/efeitos adversos , Fimose/cirurgia , Adulto , Sudeste Asiático/etnologia , Circuncisão Masculina/métodos , Medicamentos de Ervas Chinesas/toxicidade , Prepúcio do Pênis/efeitos dos fármacos , Prepúcio do Pênis/patologia , Granuloma de Corpo Estranho/etiologia , Humanos , Masculino , Ereção Peniana/efeitos dos fármacos , Fimose/etiologia , Automedicação , Vasodilatadores/toxicidade , WisconsinRESUMO
A case is reported in which temozolomide, a promising new DNA alkylating agent, was successfully used to treat radiation refractory metastatic brain tumors arising from primary breast cancer. However, the treatment had to be terminated after the second round of treatment due to the development of hemorrhagic cystitis. This side effect was totally unexpected. Another class of alkylating agents (cyclophosphamide and related compounds) exhibits this side effect caused by a prevalent acrolein metabolite. Temozolomide and its sister compounds, dacarbazine and 5-(3-methyltriazen-1-yl)imidazole-4-caroxamide, have never been reported to have this adverse reaction. This case serves to alert physicians to the existence of a possible subpopulation of patients who may experience hemorrhagic cystitis on treatment with imidazotetrazines by a mechanism that is yet to be established.