Assuntos
Doenças Autoimunes/diagnóstico , Dermatite/diagnóstico , Exantema/diagnóstico , Icterícia Obstrutiva/diagnóstico , Menorragia/tratamento farmacológico , Acetato de Noretindrona/efeitos adversos , Progesterona/efeitos adversos , Administração Oral , Doenças Autoimunes/complicações , Doenças Autoimunes/imunologia , Doenças Autoimunes/patologia , Bilirrubina/sangue , Anticoncepcionais Femininos/efeitos adversos , Anticoncepcionais Femininos/uso terapêutico , Dermatite/complicações , Dermatite/imunologia , Dermatite/patologia , Exantema/induzido quimicamente , Exantema/patologia , Feminino , Glucocorticoides/administração & dosagem , Glucocorticoides/uso terapêutico , Humanos , Icterícia Obstrutiva/induzido quimicamente , Menorragia/complicações , Acetato de Noretindrona/uso terapêutico , Prednisolona/administração & dosagem , Prednisolona/uso terapêutico , Progesterona/imunologia , Resultado do Tratamento , Adulto JovemAssuntos
Neoplasias Ósseas , Linfadenopatia , Plasmocitoma , Humanos , Plasmocitoma/complicações , Costelas , Síndrome , Adesivo TransdérmicoRESUMO
BACKGROUND: Autologous non-cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES preparation. OBJECTIVES: To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory-based method (lab-NCES). METHODS: Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation. RESULTS: Repigmentation outcome in 4C method as compared to lab-NCES was as follows: excellent (≥90%) repigmentation: 34% vs. 37%, P = 1.000, good (≥75%) repigmentation: 68% vs. 71%, P = 1.000; colour match: 59% vs. 54%, P = 0.794, patient satisfaction based on PGA score - 23.02 vs. 23.39 (P = 0.210) and major pattern of repigmentation (diffuse) - 76% vs. 71% (P = 0.618). LIMITATIONS: Short follow-up period of 16 weeks. CONCLUSION: Four compartment method is a simple and effective technique for vitiligo surgery in routine clinical practice.