An axisymmetric mirror device for studying confinement and instability.

We describe a magnetic mirror device, namely, the Keda Mirror with AXisymmetricity (KMAX), which aims to study new approaches to confine and stabilize the mirror plasma as well as basic plasma research. KMAX consists of one central cell, two side cells, and two end chambers at two ends of the device. For the central cell, the mirror-to-mirror distance is 5.2 m, while the central cylinder is 2.5 m in length and 1.2 m in diameter. The plasmas are generated by two washer guns located in the end chambers, which subsequently flow into the central cell and merge there. The density in the central cell is usually adjusted by changing the magnetic field strength inside the side cell, and it ranges from 1017 to 1019 m-3, depending on the experimental requirement. Ion cyclotron frequency heating with two 100 kW transmitters is routinely used to heat up the ions. Plasma controls mainly rely on configuring the magnetic geometry and rotating magnetic fields to improve the confinement and suppress instability. Routine diagnostics, such as probes, interferometers, spectrometers, diamagnetic loops, and bolometers, are also reported in this paper.

Causal association between cardiovascular diseases and erectile dysfunction, a Mendelian randomization study.

Background: Cardiovascular diseases (CVD), including coronary heart disease (CHD), heart failure, ischemic heart disease (IHD), and atrial fibrillation, are prevalent in the aged. However, the influence of CVD on ED is less investigated. This study was performed to clarify the causal association between CVD and ED. Materials and methods: Genome-wide association studies (GWAS) datasets targeting CHD, heart failure, IHD, and atrial fibrillation were downloaded to retrieve single nucleotide polymorphisms (SNPs). Further, single-variable Mendelian randomization and multivariable Mendelian randomization (MVMR) were adopted to explore the causal association between CVD and ED. Results: Genetically predicted CHD and heart failure were found to increase the risks of ED (OR = 1.09, P < 0.05 and OR = 1.36, P < 0.05, respectively). However, no causal association was disclosed among IHD, atrial fibrillation and ED (all P > 0.05). These findings remained consistent in sensitivity analyses. After controlling for body mass index, alcohol, low density lipoprotein, smoking and total cholesterol levels, the results of MVMR support the causal role of CHD on ED (P < 0.05). Similarly, the direct causal effect estimates of heart failure on ED were significant in MVMR analyses (P < 0.05). Conclusion: Using genetic data, this study revealed that genetically predicted CHD and heart failure may predict better ED compared with atrial fibrillation and IHD. The results should be interpreted with caution and the insignificant causal inference of IHD still needs further verification in future studies.

Formation of field-reversed configuration using an in-vessel odd-parity rotating magnetic field antenna in a linear device.

A Field-Reversed Configuration (FRC) is formed by an in-vessel odd-parity rotating magnetic field (RMF) antenna in a tandem mirror device, Keda mirror with axisymmetricity. The 40-cm diameter antenna is fed independently by four IGBT-based power units with an output current of 1500 A each at 84 kHz, and their phases are adjustable to launch odd or even parity RMFs. A medium-sized washer gun is utilized to generate a highly ionized seed hydrogen plasma. Driven by RMF, the resultant FRC is formed with a separatrix radius of ∼17 cm, external field of ∼50 G, and trapped poloidal flux of ∼0.15 mWb. The formation process of FRCs is evidenced by the measurement of an array of internal two-dimensional probes; a comparison with the rigid rotor model is presented in this paper. In addition, substantial toroidal electron current is found to be driven, despite the partial RMF penetration. Moreover, the dependence of the driven current on the antenna current is reported and is found to be consistent with the RMF current driving model.

The impact of cyclin D1 overexpression on the prognosis of bladder cancer: a meta-analysis.

BACKGROUND: To evaluate the relationship between cyclin D1 overexpression and bladder cancer prognosis. METHODS: A systematic literature search up to July 27, 2013 was carried out in PubMed and Wanfang databases, and the references of retrieved articles were screened. The hazard ratios (HRs) and their 95% CIs were used to combine the data. Heterogeneity and publication bias were also evaluated. RESULTS: A total of 15 studies containing 2,591 cases were included. We found that increased cyclin D1 levels were significantly correlated with progression-free survival with a pooled HR estimate of 0.54 (95% CI: 0.32-0.92). There was a significant degree of heterogeneity (I² = 93.8%, P <0.001). Moreover, subgroup analysis indicated that elevated cyclin D1 levels were significantly associated with overall survival in muscle-invasive bladder patients (HR: 0.95, 95% CI: 0.91-0.99), without a significant heterogeneity in the data (I² = 0.0%, P = 0.456). CONCLUSIONS: Increased cyclin D1 expression level detected by immunohistochemistry is associated with good progression-free survival for bladder cancer. Because of the limited number of studies, further well-designed prospective studies are warranted to confirm the findings from our study.