Investigating hybrid nanoparticles for drug delivery in multi-stenosed catheterized arteries under magnetic field effects.

This groundbreaking study pioneers the exploration of the therapeutic implications of a constant magnetic field simultaneously with hybrid nanoparticles on blood flow within a tapered artery, characterized by multiple stenosis along its exterior walls and a central thrombus, employing three-dimensional bio-fluid simulations. In addition, a magnetized catheter is inserted into the thrombus to increase the therapeutic potential of this novel method. The flow condition under consideration has applications in targeted medication distribution, improved medical device design, and improved diagnostics, as well as in advancing healthcare and biomedical engineering. Our investigation primarily aims to optimize blood flow efficiency, encompassing key parameters like pressure, velocity, and heat fluctuations influenced by diverse geometric constraints within the stenotic artery. Precise solutions are obtained through the finite element method (FEM) coupled with advanced bio-fluid dynamics (BFD) software. Hybrid nanoparticles and magnetic fields impacted pressure and velocity, notably reducing pressure within the stenosis. Convective heat flux remained uniform, while temperature profiles showed consistent inlet rise and gradual decline with transient variations. This approach promotes fluid flow, and convection within stenosed arteries, enhances heat transport, evacuates heat from stenotic regions, and improves heat dispersion to surrounding tissues. These findings hold promise for targeted therapies, benefiting patients with vascular disorders, and advancing our understanding of complex bio-fluid dynamics.

Mathematical inspection of heat transfer and unsteady viscous flow in a tunnel with trapezoidal shaped slender wall.

An exploration is made to investigate numerically and theoretically the time dependent flow of blood along with heat transfer through abnormal artery having trapezoidal shaped plaque. The flow is taken to be Newtonian, laminar, unsteady and incompressible. A suitable geometrical model is constructed to simulate the trapezoidal stenosis affected artery. The governed 2-dimensional momentum and heat transfer equations are conventionalized by assuming mild trapezoidal stenosis. The renovate partial differential equations are further converted into ordinary differential equations by assist of transformations. The novelty of the work is to consider unsteady blood flow through trapezoidal shape stenosed artery. A technique of finite difference is used to discretize the updated dimensionless model numerically. Comprehensive graphical outcomes for a flow of blood are obtained. The effect of trapezoidal plaque on blood velocity, pressure and temperature are shown by surface graph inside the artery and also shown with the help of line graph.

Effects of stenosis and aneurysm on blood flow in stenotic-aneurysmal artery.

Blood is indeed a suspension of the different type of cells along with shear thinning, yield stress and viscoelastic characteristics, which can be expressed by Newtonian and a lot of non-Newtonian models. Choosing Newtonian fluid as a sample, an unsteady solver for Newtonian fluid is constructed to determine the transient flow of blood in the obscure region. In this probe, the computational unsteady flow of blood in artery with aneurysm and symmetric stenosis has been considered, which is novelty of current research. The results of this investigation can be applied to detect stenotic-aneurysmal diseases and enhance knowledge of the stenotic-aneurysmal artery, which may increase the understanding of medical science. The blood artery is modeled as a circular tube having a 0.3-m radius and a 2-m length along the horizontal axis. The velocity of blood is taken at 0.12 ms-1 so that the geometry satisfies the characteristics of the blood vessel. The governing mass and momentum equations are then solved by finite difference technique of discretization. In this research, important variations in blood pressure and velocity at stenosis and aneurysms in the artery are found. The significant influences on blood flow of the stenotic-aneurysmal artery for pressure and velocity profiles of blood are displayed graphically for the Newtonian model.

Assessment of heat transfer and the consequences of iron oxide (Fe3O4) nanoparticles on flow of blood in an abdominal aortic aneurysm.

The present study is established on a simulation using CFD analysis in COMSOL. Blood acted as the base fluid with this simulation. The taken flow is been modeled as incompressible, unsteady, laminar and Newtonian fluid, which is appropriate at high rates of shear. The characteristic of flow of blood is been studied in order to determine pressure, velocity and temperature impact caused by an abdominal aortic aneurysm (AAA). This work employs nanoparticles of the Iron Oxide (Fe3O4) type. The CFD technique is utilized to evaluate the equations of mass, momentum, and energy. The COMSOL software is utilized to generate a normal element sized mesh. The findings of this study demonstrate that velocity alters through aneurysmal part of the aorta, that velocity is higher in a diseased segment, and that velocity increases before and after the aneurysmal region. For the heat transfer feature, the reference temperature and general inward heat flux is taken as 293.15K and 800W/m2. The nanoparticles altered blood's physical properties, including conductivity, dynamic viscosity, specific heat, and density. The inclusion of Iron Oxide (Fe3O4) nanoparticles managed to prevent overheating because taken nanoparticles have significant thermal conductivity. These findings will be extremely beneficial in the treatment of abdominal aortic aneurysm.