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1.
Bone Marrow Transplant ; 52(6): 878-882, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28218751

RESUMO

Chronic GvHD-related keratoconjunctivitis sicca (cGvHD-related KCS) can significantly alter the quality of life of patients after allogeneic hematopoietic stem cell transplantation. The aim of this work was to assess the efficacy and tolerability of scleral lenses to treat severe cGvHD-related KCS. In this retrospective, multicenter study, we included 60 consecutive patients diagnosed with cGvHD-related KCS and fitted with scleral lenses. Patients were evaluated at baseline and at 2 months with the following tests: the Ocular Surface Disease Index (OSDI) to assess quality of life, the Oxford score to grade corneal damage and the logarithm of minimal angle of resolution (Log MAR) scale to determine visual acuity. We observed improvement in quality of life in 58 patients (97%). All parameters improved at 2 months. We observed significant differences at 2 months compared with baseline for the mean OSDI (86 versus 30, respectively, P<0.001), the mean Oxford score (3.2 versus 1.3, respectively, P<0.001) as well as visual acuity (Log MAR of 0.33 versus 0.10, respectively, P<0.001). Treatment with scleral lenses was discontinued in only 5 patients (8%) with a median follow-up of 20.5 months (range: 2-125 months). Scleral lenses were very efficient and well tolerated in patients with severe cGvHD-related KCS.


Assuntos
Doença Enxerto-Hospedeiro , Transplante de Células-Tronco Hematopoéticas , Ceratoconjuntivite Seca , Cápsula do Cristalino/patologia , Qualidade de Vida , Índice de Gravidade de Doença , Adolescente , Adulto , Idoso , Aloenxertos , Criança , Doença Crônica , Feminino , Doença Enxerto-Hospedeiro/patologia , Doença Enxerto-Hospedeiro/terapia , Humanos , Ceratoconjuntivite Seca/etiologia , Ceratoconjuntivite Seca/patologia , Ceratoconjuntivite Seca/terapia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
2.
Rev Med Brux ; 19(2): 73-5, 1998 Apr.
Artigo em Francês | MEDLINE | ID: mdl-9643086

RESUMO

We report on a case of a 66 years-old patient suffering weight loss and lumbar pain, localized at L2-L3. A spondylodiscitis was revealed by CT and MRI; intervertebral disc puncture was positive for Pneumococcus Pneumoniae. The clinical evolution was good with the anti-bacterial treatment, while the patient developed a synostosis L2-L3. Incidence, bacteriology, imaging and therapy of spondylodicitis are discussed.


Assuntos
Discite/diagnóstico , Vértebras Lombares , Infecções Pneumocócicas/diagnóstico , Idoso , Antibacterianos/uso terapêutico , Discite/tratamento farmacológico , Humanos , Imageamento por Ressonância Magnética , Masculino , Infecções Pneumocócicas/tratamento farmacológico , Punção Espinal , Tomografia Computadorizada por Raios X
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