Contribution of Illicit Drug Use to Pharmaceutical Load in the Environment: A Focus on Sub-Saharan Africa.

Illicit drug abuse and addiction are universal issues requiring international cooperation and interdisciplinary and multisectoral solutions. These addictive substances are utilized for recreational purposes worldwide, including in sub-Saharan Africa. On the other hand, conventional wastewater treatment facilities such as waste stabilization ponds lack the design to remove the most recent classes of pollutants such as illicit drug abuse. As a result, effluents from these treatment schemes contaminate the entire ecosystem. Public health officials are concerned about detecting these pollutants at alarming levels in some countries, with potential undesirable effects on aquatic species and increased health hazards through exposure to contaminated waters or recycling treated or untreated effluents in agriculture. Contaminants including illicit substances enter the environment by human excreta following illegal intake, spills, or through direct dumping, such as from clandestine laboratories, when their manufacturer does not follow accepted production processes. These substances, like other pharmaceuticals, have biological activity and range from pseudopersistent to highly persistent compounds; hence, they persist in the environment while causing harm to the ecosystem. The presence of powerful pharmacological agents such as cocaine, morphine, and amphetamine in water as complex combinations can impair aquatic organisms and human health. These compounds can harm human beings and ecosystem health apart from their low environmental levels. Therefore, this article examines the presence and levels of illicit substances in ecological compartments such as wastewater, surface and ground waters in sub-Saharan Africa, and their latent impact on the ecosystem. The information on the occurrences of illicit drugs and their metabolic products in the sub-Saharan Africa environment and their contribution to pharmaceutical load is missing. In this case, it is important to research further the presence, levels, distribution, and environmental risks of exposure to human beings and the entire ecosystem.

A review on the potential of underutilized Blackjack (Biden Pilosa) naturally occurring in sub-Saharan Africa.

Several Indigenous edible vegetables in sub-Saharan countries have potential bioactive compounds, including underutilized Biden pilosa (BP). Bioactives from Indigenous edible vegetables are re-evolving as an alternative medicine potential for drug formulations. BP has also been used to mitigate over 40 different diseases in people and animals as herbal medication. Due to globalization and urbanization, people move from more active to more sedentary lifestyles, home-cooked meals to fast foods and snacks, organic foods to processed food with high sugar, salt, and fat. The consumption of native fruits and vegetables is now replaced by a highly processed calory diet, leading to metabolic syndromes such as diabetes, obesity, and other diet-related non-communicable diseases. Hence this article was designed to investigate the existing reports on the use, knowledge and the need to utilize the potentiality of BP further to overcome nutritional deficiencies, food scarcity and mitigation of medical conditions in sub-Saharan Africa. The use of plant-based drugs will aid to decrease the health capitation load as most countries do not have enough funds for purchasing synthetic chemicals used to mitigate diseases.