Comprehensive Patient-Specific Intensity-Modulated Radiation Therapy Quality Assurance Comparing Mobius3D/FX to Conventional Methods of Evaluation.

Purpose To determine the appropriateness of implementing Mobius3D/FX (Varian Medical Systems, Inc., Palo Alto, CA, USA) as not only a pretreatment secondary check but as an alternative to measurement-based patient-specific intensity-modulated radiation therapy (IMRT) quality assurance (QA). Methods Mobius3D/FX was commissioned and stock beam models were tweaked so that an independent recalculated 3D dose distribution can be obtained. Then, 50 patient-specific treatment plans for various indications were delivered across a 2D ion chamber array, radiochromic film setup, and electronic portal imager and analyzed with MobiusFX and gamma analysis. The concordance of plans scored as passing between MobiusFX and the conventional methods of QA was determined. Results All analyzed treatment plans passed with a gamma passing rate >90% across all conventional QA methods, most commonly using a 3%/3mm gamma criterion except for film measurements where a 5%/3mm criterion was applied. There was good agreement and concordance between MobiusFX and conventional methods when using a 3%/3mm criteria for MobiusFX, whereas a 2%/2mm criteria appeared too stringent as it failed treatment plans deemed clinically acceptable using conventional methods. Conclusions Using a 50-sample subset of clinically delivered treatment plans this non-inferiority-type comparison shows Mobius3D/FX based on log file analysis to be a suitable alternative to conventional QA methods when utilizing the 3%/3mm gamma criterion. Methods based on log file analysis can provide an opportunity for resource sparing, improving the efficiency, and workflow for evaluating IMRT treatment plans.

Timing matters: length of leave and working mothers' daily reentry regrets.

Dealing with developmental tasks in work and family domains is an important challenge for young and middle-aged adults. We investigated a transition that has evolved into a normative task for women, namely, the retransition back to paid work following maternity leave. In a diary study with 149 mothers who had just returned to work, we examined the daily experienced regrets concerning this return. In addition to personal resources (i.e., emotional stability, feeling prepared for the transition) and financial requirements needed to return to work, daily experienced family stress predicted decisional regrets. Moreover, our results suggest that leave length is related to psychological resilience in the face of day-to-day stress experiences: Late returners reported fewer regrets in general and were unaffected by daily family stress. Return-to-work regrets, in turn, were predictive of withdrawal intentions. This underlines the relevancy of the timing of the transition back to work in terms of successful development during this life phase.

A 32-channel lattice transmission line array for parallel transmit and receive MRI at 7 tesla.

Transmit and receive RF coil arrays have proven to be particularly beneficial for ultra-high-field MR. Transmit coil arrays enable such techniques as B(1) (+) shimming to substantially improve transmit B(1) homogeneity compared to conventional volume coil designs, and receive coil arrays offer enhanced parallel imaging performance and SNR. Concentric coil arrangements hold promise for developing transceiver arrays incorporating large numbers of coil elements. At magnetic field strengths of 7 tesla and higher where the Larmor frequencies of interest can exceed 300 MHz, the coil array design must also overcome the problem of the coil conductor length approaching the RF wavelength. In this study, a novel concentric arrangement of resonance elements built from capacitively-shortened half-wavelength transmission lines is presented. This approach was utilized to construct an array with whole-brain coverage using 16 transceiver elements and 16 receive-only elements, resulting in a coil with a total of 16 transmit and 32 receive channels.

Midlife crisis: a debate.

Without doubt, the midlife crisis is the most popular concept describing middle adulthood. Facing the limitation of the time until death, men in particular are believed to pause from actively pursuing their goals and review their achievements, take stock of what they have and have not yet accomplished, at times taking drastic measures to fulfill their dreams. This paper critically discusses the concept of a midlife crisis and the relevant empirical evidence, presenting arguments for and against a strict, a moderate, and a lenient conceptualization of the midlife crisis. Although a strict and even moderate definition of the midlife crisis does not seem tenable on empirical and theoretical grounds, a lenient conceptualization has the potential to stimulate new research directions exemplifying processes of the interaction of social expectations on the one hand and personal goals on the other, and their importance for developmental regulation.

A geometrically adjustable 16-channel transmit/receive transmission line array for improved RF efficiency and parallel imaging performance at 7 Tesla.

A novel geometrically adjustable transceiver array system is presented. A key feature of the geometrically adjustable array was the introduction of decoupling capacitors that allow for automatic change in capacitance dependent on neighboring resonant element distance. The 16-element head array version of such an adjustable coil based on transmission line technology was compared to fixed geometry transmission line arrays (TLAs) of various sizes at 7T. The focus of this comparison was on parallel imaging performance, RF transmit efficiency, and signal-to-noise ratio (SNR). Significant gains in parallel imaging performance and SNR were observed for the new coil and attributed to its adjustability and to the design of the individual elements with a three-sided ground plane.

B(1) destructive interferences and spatial phase patterns at 7 T with a head transceiver array coil.

RF behavior in the human head becomes complex at ultrahigh magnetic fields. A bright center and a weak periphery are observed in images obtained with volume coils, while surface coils provide strong signal in the periphery. Intensity patterns reported with volume coils are often loosely referred to as "dielectric resonances," while modeling studies ascribe them to superposition of traveling waves greatly dampened in lossy brain tissues, raising questions regarding the usage of this term. Here we address this question experimentally, taking full advantage of a transceiver coil array that was used in volume transmit mode, multiple receiver mode, or single transmit surface coil mode. We demonstrate with an appropriately conductive sphere phantom that destructive interferences are responsible for a weak B(1) in the periphery, without a significant standing wave pattern. The relative spatial phase of receive and transmit B(1) proved remarkably similar for the different coil elements, although with opposite rotational direction. Additional simulation data closely matched our phantom results. In the human brain the phase patterns were more complex but still exhibited similarities between coil elements. Our results suggest that measuring spatial B(1) phase could help, within an MR session, to perform RF shimming in order to obtain more homogeneous B(1) in user-defined areas of the brain.