RESUMO
Melanoma is known to show considerable variation in its histopathological presentation. In exceptional cases, heterologous or divergent differentiation (metaplastic melanoma) can be observed. We report a case of a 69-year-old man who was diagnosed with nodular melanoma on the right upper leg. One year later, the patient presented with an inguinal lymph node metastasis and a lymph node dissection was carried out. In two out of five positive lymph nodes, an angiosarcomatous component was found next to a conventional melanoma component. Shortly after, the patient developed two in-transit metastases in which again an angiosarcomatous component was seen. The vascular component stained positive for ERG and CD31 and negative for melanocytic markers (Mart-1, S100, SOX-10), while the conventional melanoma had an opposite staining pattern. Molecular analysis on both components showed an identical mutation in the NRAS gene, which in our opinion proves the divergent differentiation. To the best of our knowledge, this is the first case report describing angiosarcomatous transdifferentiation of melanoma.
Assuntos
Hemangiossarcoma/tratamento farmacológico , Hemangiossarcoma/patologia , Canal Inguinal/patologia , Metástase Linfática/diagnóstico , Melanoma/secundário , Neoplasias Cutâneas/secundário , Idoso , Transdiferenciação Celular/genética , GTP Fosfo-Hidrolases/genética , Hemangiossarcoma/irrigação sanguínea , Hemangiossarcoma/metabolismo , Humanos , Inibidores de Checkpoint Imunológico/uso terapêutico , Imuno-Histoquímica , Excisão de Linfonodo/métodos , Masculino , Proteínas de Membrana/genética , Mutação , Nivolumabe/uso terapêutico , Cuidados Paliativos , Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismo , Regulador Transcricional ERG/metabolismo , Resultado do Tratamento , Melanoma Maligno CutâneoAssuntos
Vesículas Extracelulares/imunologia , Lúpus Eritematoso Cutâneo/imunologia , Lúpus Eritematoso Cutâneo/patologia , Proteínas Nucleares/imunologia , Biópsia por Agulha , Bases de Dados Factuais , Feminino , Técnica Direta de Fluorescência para Anticorpo/métodos , Humanos , Imuno-Histoquímica , Masculino , Estudos RetrospectivosRESUMO
BACKGROUND: The current knowledge about potential risk factors for lymph node (LN) metastasis in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) is primarily based on studies that lack adjustment for confounding variables. OBJECTIVES: We sought to identify independent risk factors for LN metastasis in patients with HNcSCC and to evaluate the impact of LN metastasis on prognosis. METHODS: Patients with primary HNcSCC were retrospectively included. Potential risk factors were analyzed by univariate and multivariate Cox regression models. Survival was compared using the Kaplan-Meier method. RESULTS: Three hundred thirty-six patients with 545 primary HNcSCCs were included. The median follow-up period was 43 months (range, 1-176 months). LN metastasis occurred in 55 patients (16.4%). The following independent risk factors of HNcSCC for the development of LN metastasis were identified: location on the ear, tumor diameter >50 mm, moderate and poor differentiation, and tumor thickness >2 mm. There was a significant decline in disease-specific survival and overall survival in patients with LN metastasis compared to patients without LN metastasis. LIMITATIONS: The retrospective study design. CONCLUSION: LN metastases from HNcSCC are common with diminished survival rates. This study confirmed some well-known risk factors, but also found moderate differentiation as an independent risk factor for LN metastasis.