Parotid Mucoepidermoid Carcinoma in a Pediatric Patient: A Case Report.

Mucoepidermoid carcinomas (MECas) are malignant epithelial salivary gland neoplasms composed of a variable mixture of epidermoid and mucus-secreting cells arising from the ductal epithelium. Of all salivary gland tumors, MECas are the most common malignant lesions of the parotid gland. This case report aims to present a 14-year-old female patient with a history of progressive enlargement of a 3 cm in diameter, painless, mobile mass located at the parotid gland without facial nerve dysfunction. The lesion was exhaustively studied preoperatively, and studies were carried out. Contrast-enhanced computerized tomography (CECT) showed an increase in nodule numbers and size at the level of both the jugular and posterior cervical chains. In contrast, the gland's fine needle aspiration (FNA) showed a mucinous background. The histologic depiction established that the tumor was MECa of the parotid gland. The literature reviews on MECa encompass discussions about its prevalence, etiology, histological findings, and treatment.

New-Onset Type 1 Diabetes in Children With SARS-CoV-2 Infection.

There has been a worldwide increase in cases of diabetic ketoacidosis in both adults and children with diabetes during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. This can be multifactorial: delayed care due to reduced medical services, fear of approaching hospitals, or SARS-CoV-2 infection itself. It is well-known that infection is an important trigger for diabetic ketoacidosis in children with type 1 or type 2 diabetes mellitus, but little is known whether SARS-CoV-2 infection can trigger diabetic ketoacidosis and new-onset diabetes mellitus in a child with no previous history of diabetes mellitus. The association of SARS-CoV-2 as a trigger for new-onset diabetes requires further investigation, as the incidence of diabetes is steadily rising in the pediatric population during the pandemic. This case report explores two cases where children present in diabetic ketoacidosis with concurrent SARS-CoV-2 infection and no known history of type 1 diabetes mellitus.

Benzocaine-induced methaemoglobinaemia in an adolescent with sepsis.

Methaemoglobinaemia is a potentially life-threatening condition characterised by hypoxaemia, cyanosis, pallor, fatigue, metabolic acidosis, headache and in severe cases, coma or death. Topical anaesthetics have been reported to cause methaemoglobinaemia. Topical benzocaine was specifically implicated in roughly 66% of anesthetic-induced methaemoglobinaemia cases in a large systematic review in adults. This complication has occurred often in adult patients with pre-existing comorbidities resulting in diminished use in children overall with only few paediatric cases reported worldwide. Additionally, there is growing evidence of a link between sepsis and methaemoglobinaemia due to increased circulating nitrous oxide from infectious pathogen metabolism. In this report, we discuss a case of a 16-year-old young boy, being evaluated for suspected endocarditis, presenting with acute methaemoglobinaemia after use of topical benzocaine spray for transesophageal echocardiogram. This case exemplifies the importance of blood gas with co-oximetry testing in all cases of refractory hypoxemia who have had procedures requiring topical anaesthetics.

Quality-of-Life Metrics Correlate With Disease Severity in Idiopathic Subglottic Stenosis.

OBJECTIVES: Idiopathic subglottic stenosis (ISGS) can have significant impacts on quality of life (QOL), but it remains unclear how patients' subjective responses correlate with objective measurement of disease severity. Peak expiratory flow percentage (PEF%) has been shown to be an effective measure of disease severity in subglottic stenosis. This study aims to identify the key QOL questions correlated with PEF% and proposes a statistical model for prediction of disease severity. METHODS: Patients with ISGS presenting to an academic laryngologist were included retrospectively from 2012 to 2016. Peak expiratory flow percentage (age, sex, and height adjusted) was recorded for each visit, along with four validated QOL instruments (European QOL-Five Dimensions; RAND 36-Item Health Survey; Clinical COPD [Chronic Obstructive Pulmonary Disease] Questionnaire; and the Airway, Dyspnea, Voice, and Swallowing Summary Assessment). A stepwise multiple linear regression was used to identify statistically significant independent variables correlated with PEF%, and a model was built with these variables. RESULTS: Thirty-two patients were included, with a total of 271 patient encounters. Overall scores from each of the four QOL instruments were correlated with PEF% values recorded each visit (P < 0.05). Question responses correlating most positively included overall breathlessness, difficulty catching breath, cough within the past week, dyspnea with moderate activity, perception that voice changes are restricting social life, and overall general health (all P < 0.01). A model constructed using six nonoverlapping questions yielded an adjusted R2 of 0.58. CONCLUSION: Quality of life is correlated to PEF% in ISGS. Using a limited number of QOL questions, clinicians can predict objective worsening or improvement of disease severity, as measured by spirometry. LEVEL OF EVIDENCE: 2b. Laryngoscope, 2017.

A Comparative Study of Pre and Post-prandial BP Recordings in Obese and Non Obese Young Adults.

INTRODUCTION: Obesity is associated with varied combinations of abnormalities in the autonomic nervous system. Studies have shown that obese people who have a higher sympathetic tone have higher catecholamine levels. This can predispose to arythmogenesis and sudden death. AIM: To study pre and post-prandial BP recordings in obese and non obese young adults in the age group of 18 to 45 years. MATERIALS AND METHODS: The study was conducted on 50 obese and 50 non obese patients admitted to our hospital over a period of three months. The patients are randomly selected and the BMI is calculated. Both systolic and diastolic blood pressure is measured in supine position of the right arm using digital electronic blood pressure monitor. BP recordings are taken 30 minutes before and 30 minutes after meals. Then fall in BP is recorded. RESULTS: From this study we found that the mean systolic (pre-prandial 124.36, post-prandial 116.6) and diastolic blood pressure (pre-prandial 78.8 and post-prandial 75.4) is higher in obese than non obese patients. The study was statistically significant which was found by paired t-test (p<0.05). CONCLUSION: The fall in BP was significantly higher in obese (12 patients out of 50) than non obese (5 patients out of 50) patients. Probably obese patients had reduced cardiac sympathetic tone which caused post-prandial hypotension more than non obese patients.

GALAXY EVOLUTION. An over-massive black hole in a typical star-forming galaxy, 2 billion years after the Big Bang.

Supermassive black holes (SMBHs) and their host galaxies are generally thought to coevolve, so that the SMBH achieves up to about 0.2 to 0.5% of the host galaxy mass in the present day. The radiation emitted from the growing SMBH is expected to affect star formation throughout the host galaxy. The relevance of this scenario at early cosmic epochs is not yet established. We present spectroscopic observations of a galaxy at redshift z = 3.328, which hosts an actively accreting, extremely massive BH, in its final stages of growth. The SMBH mass is roughly one-tenth the mass of the entire host galaxy, suggesting that it has grown much more efficiently than the host, contrary to models of synchronized coevolution. The host galaxy is forming stars at an intense rate, despite the presence of a SMBH-driven gas outflow.

Cruciate incision for treatment of primary/recurrent cases of seroma/hematoma of pinna : a novel approach.

INTRODUCTION: Seroma of pinna have a high predisposition for recurrence. Its surgical management requires excision of cartilage and perichondrium which can cause scarring, deformity of pinna, perichondritis and abscess formation, postoperatively.The aim of the current study is to the access the outcome of a novel approach using cruciate incision for surgical treatment of seroma/ hematoma of pinna. MATERIALS AND METHODS: Study was conducted at Father Muller Medical College in the Department of Otorhinolaryngology for a period of three months between January 2014 to March 2014 during which period 30 patients with seroma of the pinna were taken up for the study. Procedure was done under local anaesthesia with all aseptic precautions. A cruciate incision was given over the most dependent part of the swelling and flaps were raised. The collection was drained and the under surface of the flap was scraped using Rosen's knife followed by pressure dressing for three days. Patients were followed up for three months. RESULTS: A total of 30 patients with seroma were studied. Out of the 30 cases 24 were primary cases and 6 were recurrent cases. Majority of the patients were in the age group 41-50 y. Out of 30 patients 18 were males and 12 were females. Out of 30 patients studied, none of them had recurrence. Four patients however developed perichondrial reaction with pain and inflammation which required analgesics and antibiotics. In 6 cases a thickening of the auricle at the site of incision was noticed which resolved over a period of 4 to 5 months. Overall cosmetic deformity was negligible with most of the patients showing a negligible scar after 6 months of follow up. CONCLUSION: Cruciate incision is a good technique for treatment of seroma and hematoma of pinna as the outcome is good with no recurrence.

Role of Gender and Serum Immunoglobulin E (IGE) levels on Severity of Migraine.

AIM: Migraine headache is a common disorders. Several studies have reported that migraine headache is more common in patients with allergy. AIM of this study is to determine if the allergic sensitization is associated with the prevalence, frequency, and disability of migraine headaches. MATERIALS AND METHODS: The study was conducted during the period August 2013. During this period 100 patients of either gender who were diagnosed with migraine were selected and total serum Immunoglobulin E (IGE) levels were estimated. Prevalence of migraine headache and degree of allergic sensitization was estimated in these patients. Severity of migraine was assessed using the MIDAS score. Statistical Analysis : Descriptive tables were generated showing the demographic and clinical characteristics of participants stratified by age and sex. Differences between subject groups were assessed by chi-square test. Correlation between severity of migraine and IgE levels was calculated using Pearson correlation. RESULTS: A total of 100 patients with migraine who presented to the outpatient department where studied. Prevalence of migraine was found to be higher in females compared to males. At the younger age group IgE levels were higher. Patients with higher levels of IgE had more severe headaches compared to those with lower levels of IgE. Patients with higher levels of IgE required a longer duration of treatment compared to those with lower levels of IgE. CONCLUSION: Prevalence of migraine is high among females. Younger age and female sex are other contributory factors as prevalence of migraine is higher in these groups. Degree of allergic sensitisation determines the severity and frequency of headaches in those whom allergic rhinitis is a risk factor as evidenced by higher levels of IgE.

Journey of change and back: a case study of a reconstituted social work service.

As a result of Total Quality Management and Reengineering principles during the VA's "Journey of Change" in the mid-1990s many hospital social work departments were re-organized under umbrella-care lines. Outcome studies of this movement have focused primarily on patient services. This study focused on the service providers' (including social workers) point of view and their satisfaction with the change in service structure. Data gathering consisted of a master thesis project by one of the co-authors, an administrative in-house survey of staff satisfaction, a qualitative presentation of staff concerns, and the perspective of the administrator who took the decision.

Does Silybum marianum play a role in the treatment of chronic hepatitis C?

OBJECTIVES: The recent boom in patient education on chronic hepatitis C has resulted in a worldwide increase in the diagnosis of this condition. Available treatment is expensive and associated with significant side effects; therefore, many patients seek for alternative medicine. Silybum marianum is a natural herb known to mankind for over 2,000 years that has been used as a liver-protecting agent due to its antioxidant properties. The objective of this study is to evaluate the safety profile and the effects of this herb, using a commercially available extract; in the liver chemistry and viral load of hepatitis C in chronically infected patients. METHODS: Patients aged 21-65 years old with a diagnosis of chronic hepatitis C who were not using antiviral therapy were asked to participate. Patients were randomized to treatment with S. marianum 160 mg orally three times a week for four weeks or to no-treatment (control). Blood tests for viral load and liver enzymes (ALT and AST) were done at randomization and at the end of treatment. Paired-t test was used to measure differences between baseline and week 4 values for ALT, AST and viral load. The percent change for ALT, AST and viral load of both groups was analyzed using the Mann Whitney statistical test. RESULTS: 34 patients were enrolled. Men and women were equally distributed. Mean age was 50 years old. Mean baseline measurements of AST, ALT and viral load in the treatment group were 85 +/- 12.41 IU/ml, 120 +/- 20.57 IU/ml and 8.77 +/- 4.12 copies x 10(6)/ml while for the no-treatment group were 71 +/- 9.46 IU/ml, 97 +/- 15.35 IU/ ml and 1.8 +/- 0.62 copies x 10(6)/ml respectively. For treated subjects the mean values of AST, ALT and viral load demonstrated a decrease from baseline values, but this difference was not statistically significant. For control patients the values of ALT (p= .049), AST (p = .005) and viral load (p = .005) showed a statistically significant increase at week 4. Week 4 measurement changes from baseline values were calculated for each participant. The percent change for ALT (p = .014), AST (p = .002) and viral load (p = .326) were compared between the treated and control group demonstrating a statistically significance difference for ALT and AST, but not for viral load. No side effects were reported using the herb extract. CONCLUSION: Sylibum marianum is a well-tolerated plant extract associated with a decrease in liver chemistries but with no apparent effect on viral load when given for 4 weeks. These results suggest that S. marianum may have a protective effect in the inflammatory response to HCV, but no role as an antiviral agent. Further investigations may consider using this plant extract for a longer period of time or as adjuvant to the standard therapy of chronic hepatitis C.