Standardization of molecular monitoring of CML: results and recommendations from the European treatment and outcome study.

Standardized monitoring of BCR::ABL1 mRNA levels is essential for the management of chronic myeloid leukemia (CML) patients. From 2016 to 2021 the European Treatment and Outcome Study for CML (EUTOS) explored the use of secondary, lyophilized cell-based BCR::ABL1 reference panels traceable to the World Health Organization primary reference material to standardize and validate local laboratory tests. Panels were used to assign and validate conversion factors (CFs) to the International Scale and assess the ability of laboratories to assess deep molecular response (DMR). The study also explored aspects of internal quality control. The percentage of EUTOS reference laboratories (n = 50) with CFs validated as optimal or satisfactory increased from 67.5% to 97.6% and 36.4% to 91.7% for ABL1 and GUSB, respectively, during the study period and 98% of laboratories were able to detect MR4.5 in most samples. Laboratories with unvalidated CFs had a higher coefficient of variation for BCR::ABL1IS and some laboratories had a limit of blank greater than zero which could affect the accurate reporting of DMR. Our study indicates that secondary reference panels can be used effectively to obtain and validate CFs in a manner equivalent to sample exchange and can also be used to monitor additional aspects of quality assurance.

The Mental Health of Mothers Currently and Formerly Incarcerated in Jails and Prisons: An Integrative Review on Mental Health, Mental Health Treatment, and Traumatic Experiences.

Most incarcerated women in the United States are mothers who report high rates of mental health issues and traumatic experiences, yet their needs are often overlooked because they comprise a smaller proportion of the incarcerated population compared with men. OBJECTIVE: This integrative review aimed to synthesize the literature on the mental health, mental health treatment, and traumatic experiences of currently and formerly incarcerated mothers. METHODS: We searched PsychINFO, CINAHL, and Criminal Justice Abstracts for all research articles that were written in English; included adult mothers who were incarcerated or incarcerated and released; and contained findings related to mental health, mental health treatment, or traumatic experiences. RESULTS: Thirty-four articles met the inclusion criteria. Mothers had high rates of moderate-to-severe mental health problems and high childhood and adult trauma rates, especially intimate partner violence. Mothers faced barriers to treatment yet showed psychological resilience and active coping skills. IMPLICATIONS: Nurses can recognize risk factors for women's incarceration and assess mental health symptoms and trauma, especially interpersonal violence. Nurses can use assessment findings to refer mothers to treatment and community resources and support their reuniting with their children. Nurses can also provide trauma-informed care and education about mental health topics and advocate for mental health treatment prerelease and postrelease. Staff education and organizational interventions to reduce burnout may remove additional barriers to care.

Confined to Obscurity: Health Challenges of Pregnant Women in Jail.

Research about pregnant women in jail is scant. This exploratory study begins to fill this gap by examining the demographics; background characteristics; and self-reported physical health, mental health, and substance use challenges reported by 27 pregnant women incarcerated in a large midwestern county jail. It further reports on the prenatal care before and during their incarceration, plans of these pregnant women for delivery of their child, caring for their infant after their release from jail, and their expectations of paternal or family support post-release. Among the sample, 66.7 percent reported a physical health care problem, 48.2 percent had received mental health treatment, and 18.5 percent had substance use treatment in the previous year, but only 51.9 percent had seen a health care professional before their incarceration. All women expected the father of their child to provide financial support, but only 76.9 percent expected the father to be involved with the child. The authors also discuss implications of the findings for jail health care services and reintegration policy and practice for pregnant women.

Developing effective social work university-community research collaborations.

In many instances, departments of social work in universities and community-based social services agencies have common interests in improving professional practice and advancing knowledge in the profession. Effective university-community research collaborations can help partners achieve these goals jointly, but to be effective these collaborative partnerships require considerable effort and understanding by all partners involved. This article provides to novice investigators and social work agencies new to research partnerships an integrated discussion of important issues to develop the groundwork necessary for building and maintaining effective university-community social work collaborations. Through experience gained from a series of social work research partnerships, as well as an overview of relevant literature, the authors offer a set of strategies for building and sustaining research collaborations between university and community-based social work professionals. The general topics discussed are technology exchange, adopting a longitudinal perspective, knowing your partners, and practical contracting/budgetary issues. The article has relevance to beginning social work researchers, social work educators, and social work practitioners seeking to engage in collaborative partnerships that improve social work practice through research and advance the knowledge base of the profession.