Suspected primary pure red cell aplasia in a 4-month-old intact male mixed breed Bernese mountain dog.

A 4-month-old, 31-kg intact male mixed-breed Bernese mountain dog was presented for evaluation of severe non-regenerative anemia after several days of lethargy, inappetence and pale mucous membranes. Bone marrow evaluation and complete response to immunosuppressive therapy were suggestive of primary pure red cell aplasia (PRCA). Primary PRCA is a rare immune-mediated non-regenerative anemia that is overrepresented in middle-aged to older spayed female dogs and has not previously been described in an intact male puppy.

Aplasie primaire pure des globules rouges suspectée chez un bouvier bernois mixte mâle intact âgé de 4 mois. Un bouvier bernois mixte mâle intact âgé de 4 mois et pesant 31 kg a été présenté pour l'évaluation d'une anémie grave non régénérative après plusieurs jours de léthargie, d'inappétence et de muqueuses pâles. L'évaluation de la moelle osseuse et la réponse complète au traitement immunosuppresseur suggéraient une aplasie primaire pure des globules rouges (PRCA). L'érythroblastopénie primaire est une anémie non régénérative à médiation immunitaire rare qui est surreprésentée chez les chiennes stérilisées d'âge moyen à plus âgées et qui n'a pas été précédemment décrite chez un chiot mâle intact.(Traduit par Dr Serge Messier).

Systemic manifestations of Cuterebra infection in dogs and cats: 42 cases (2000-2014).

OBJECTIVE To document clinical signs in cats and dogs with Cuterebra infection, determine the outcome of infected animals, and determine whether Yorkshire Terriers were more commonly affected than other breeds of dogs. DESIGN Retrospective case series. ANIMALS 22 cats and 20 dogs with Cuterebra infection. PROCEDURES Medical records of dogs and cats with Cuterebra infection were reviewed for signalment, history, clinical and laboratory findings, treatment, duration of hospitalization, and outcome. RESULTS Most (16/20 [80%]) of the dogs weighed ≤ 4.5 kg (10 lb), and Yorkshire Terriers were overrepresented (8/20 [40%]), compared with dogs of other breeds. Ten (50%) dogs and 3 (14%) cats had systemic inflammatory response syndrome at the time of initial evaluation, and 8 (40%) dogs but none of the cats had disseminated intravascular coagulation. The overall mortality rate was 17% (7/42), but was higher for dogs (6/20 [30%]) than cats (1/22 [4.5%]). All 6 dogs that died weighed ≤ 4.5 kg and had systemic inflammatory response syndrome, disseminated intravascular coagulation, or both. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that Cuterebra infection can cause severe systemic illness in small-breed dogs. Yorkshire Terriers were more commonly affected than were dogs of other breeds and, subjectively at least, appeared to be more likely to develop severe systemic illness.

Bilateral laryngeal paralysis in a dog secondary to laryngeal osseous metaplasia.

A 7-year-old spayed female Lurcher was evaluated for a chronic history of increased upper respiratory noise. Advanced imaging including digital radiography and pre- and post-contrast computed tomography (CT) scan confirmed the presence of an ill-defined soft tissue mineralized mass of the ventral larynx. Histopathology demonstrated pleocellular myositis and fasciitis with osseous metaplasia.

Paralysie laryngée bilatérale chez un chien secondaire à la métaplasie osseuse. Une chienne Lurcher stérilisée âgée de 7 ans a été évaluée pour une anamnèse chronique de bruit des voies respiratoires supérieures. Une imagerie avancée, dont une radiographie numérique et une image par tomodensitométrie avant et après contraste a confirmé la présence d'une masse minéralisée floue de tissus mous dans le larynx ventral. Unexamen histopathologique a démontré une myosite pléocellulaire et une fasciite avec une métaplasie osseuse.(Traduit par Isabelle Vallières).

Successful treatment of malakoplakia of the bladder in a kitten.

A 4-month-old female kitten presented with chronic lower urinary tract signs and Escherichia coli cystitis, and was diagnosed with urinary bladder malakoplakia based upon histopathology. The kitten was treated with a prolonged antibiotic course and the malakoplakia resolved. Malakoplakia is a chronic granulomatous reaction characterized by the formation of Michaelis-Gutman bodies within von Hansemann macrophages. It is well described in humans, but has never been documented in a living veterinary patient. This case report describes the first successful treatment of malakoplakia in veterinary medicine.

Evaluation of a single subcutaneous infusion of carboplatin as adjuvant chemotherapy for dogs with osteosarcoma: 17 cases (2006-2010).

OBJECTIVE: To evaluate adverse effects and survival times in dogs with osteosarcoma that received a single SC infusion of carboplatin as adjunctive chemotherapeutic treatment following limb amputation or limb-sparing surgery. DESIGN: Retrospective case series. ANIMALS: 17 client-owned dogs with spontaneously occurring osteosarcoma. PROCEDURES: Medical records of dogs that underwent limb amputation or limb-sparing surgery followed by a single continuous SC infusion of carboplatin (total dose, 300 mg/m(2) infused over 3, 5, or 7 days) were evaluated. Signalment, tumor location, type of surgery (amputation or limb-sparing), duration of carboplatin infusion, results of hematologic and serum biochemical analyses, and adverse effects were recorded. Kaplan-Meier survival analysis was performed. RESULTS: Median survival time for all dogs was 365 days. Nine dogs had adverse bone marrow-related (hematologic) effects, 1 had adverse gastrointestinal effects, and 7 had infections at the surgical site. No significant differences were detected in survival times of dogs grouped according to tumor location, type of surgery, duration of carboplatin infusion, or development of postoperative infection. CONCLUSIONS AND CLINICAL RELEVANCE: Median survival time and adverse effects in dogs with osteosarcoma that received a single SC infusion of carboplatin over a 3-, 5-, or 7-day period as adjunctive treatment following limb amputation or limb-sparing surgery were comparable to those of previously reported chemotherapy protocols requiring IV drug administration over several weeks. Further investigation is needed to evaluate the efficacy of this protocol as adjunctive treatment for osteosarcoma and other tumors in dogs.